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Association between ERCC2 rs13181 polymorphism and ovarian cancer risk: an updated meta-analysis with 4024 subjects

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

Genetic variants in the excision repair cross-complimentary group 2 (ERCC2) gene may affect individual susceptibility to cancer by modulating the capability of DNA damage repair. However, the current studies concerning the association of ERCC2 rs13181 polymorphism with ovarian cancer risk provided inconsistent evidence.

Methods

This study was to quantitatively summarize the evidence from the individual studies electronically retrieved by a meta-analysis.

Results

Totally, nine eligible case–control studies with 1333 cases and 2691 controls were included for the concerned association. Overall, a significant association between ERCC2 gene rs13181 polymorphism and increased risk of ovarian cancer was revealed (CC+AC vs. AA: OR 1.44, 95% CI 1.11–1.86; CC vs. AA: OR 2.12, 95% CI 1.14–3.97). Similarly, in the subgroup analyses, such association was also evident in non-Caucasian population and hospital-based studies. Noteworthily, the recombined analysis with a significant decrease in between-heterogeneity represented a significant association of the variant with increased risk of ovarian cancer after excluding the individual study not in agreement with HWE.

Conclusion

The present study suggests that the ERCC2 gene rs13181 polymorphism might be associated with increased risk of ovarian cancer.

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Acknowledgements

This work was supported by grant from the Key Discipline Project of Hubei University of Medicine.

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Author notes

  1. JieNa Li and Lei Pan contributed equally to this work.

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Heze Municipal Hospital, Heze, 274000, Shandong, China

    JieNa Li & Lei Pan

  2. Department of Obstetrics and Gynecology, Dongming People’s Hospital, Heze, 274500, Shandong, China

    Xia Qin, HongYan Chu & HuiYing Mu

  3. Department of Oncology, Renmin Hospital, Hubei University of Medicine, 39 Chaoyang Road, Shiyan, 442000, Hubei, China

    GuoXing Wan

Authors
  1. JieNa Li
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  2. Lei Pan
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  3. Xia Qin
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Contributions

JNL: project design, result interpretation, data collection, and manuscript writing. LP: result interpretation, data collection, and data analysis. XQ, HYC, and HYM: data collection. GXW: project design, result interpretation, and manuscript writing.

Corresponding author

Correspondence to GuoXing Wan.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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The authors declare that they have no conflict of interest.

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Li, J., Pan, L., Qin, X. et al. Association between ERCC2 rs13181 polymorphism and ovarian cancer risk: an updated meta-analysis with 4024 subjects. Arch Gynecol Obstet 296, 551–558 (2017). https://doi.org/10.1007/s00404-017-4443-4

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  • DOI: https://doi.org/10.1007/s00404-017-4443-4

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