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Genetic polymorphisms of ALDH2 and ADH2 are not associated with risk of hepatocellular carcinoma among East Asians

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Tumor Biology

Abstract

The aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 2 (ADH2) genes have been implicated in the development of hepatocellular carcinoma (HCC). However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the associations between polymorphisms of ALDH2 and ADH2 genes and HCC. Published literatures from PubMed and Embase were retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model. Ten studies including 1,231 HCC cases and 1,849 controls were included in the meta-analysis of the association between ALDH2 polymorphism and HCC risk. The results indicated that ALDH2 polymorphism was not significantly associated with risk of HCC (homogeneous co-dominant model: OR = 0.99, 95% CI 0.72–1.34; heterogeneous co-dominant model: OR = 0.90, 95% CI 0.75–1.08; dominant model: OR = 0.91, 95% CI 0.70–1.18; recessive model: OR = 1.11, 95% CI 0.66–1.87). In addition, four studies including 518 cases and 607 controls were included in the meta-analysis of the association between ADH2 polymorphism and HCC risk. There was no association between ADH2 polymorphism and HCC risk (homogeneous co-dominant model: OR = 0.93, 95% CI 0.58–1.51; heterogeneous co-dominant model: OR = 1.39, 95% CI 0.87–2.23; dominant model: OR = 1.19, 95% CI 0.76–1.88; recessive model: OR = 0.91, 95% CI 0.54–1.54). Further analysis suggested that the ALDH2 polymorphism–alcohol interaction was marginally associated with HCC risk under the dominant model (OR = 2.05, 95% CI 1.01–4.17). However, the result was not robust by sensitivity analysis. The results from the present meta-analysis indicated that there was no significant association between ALDH2 polymorphism, ADH2 polymorphism, or ALDH2 polymorphism–alcohol intake interaction and HCC risk in the East Asians.

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Authors and Affiliations

  1. Department of Infectious Disease, Taizhou People’s Hospital, Medical School of Nantong University, 210 Yingchun Road, Taizhou, 225300, China

    Daming Zhou, Li Xiao, Yun Zhang, Jianchun Xian, Jijun Jiang, Wenhong Zong & Zuxuan Huang

  2. Department of General Surgery, Nanjing Second Hospital, Medical School of Southeast University, Nanjing, 210003, China

    Yongfeng Yang

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  1. Daming Zhou
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  2. Li Xiao
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  3. Yun Zhang
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  4. Jianchun Xian
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  7. Zuxuan Huang
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  8. Yongfeng Yang
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Correspondence to Daming Zhou.

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Zhou, D., Xiao, L., Zhang, Y. et al. Genetic polymorphisms of ALDH2 and ADH2 are not associated with risk of hepatocellular carcinoma among East Asians. Tumor Biol. 33, 841–846 (2012). https://doi.org/10.1007/s13277-011-0309-8

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  • DOI: https://doi.org/10.1007/s13277-011-0309-8

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