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Alcohol Dehydrogenase 3, Glutathione S-transferase M1 and T1 Polymorphisms, Alcohol Consumption and Hepatocellular Carcinoma (Italy)

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Abstract

Objective:

The aim of this study was to investigate the role of alcohol dehydrogenase type 3 (ADH3), glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) polymorphisms in modifying hepatocellular carcinoma (HCC) risk according to alcohol intake.

Methods:

A hospital-based case–control study was conducted in two areas of North Italy. Two-hundred cases hospitalized for HCC and 400 controls were recruited. Genotypes were determined using PCR and the PCR/restriction fragment length polymorphism-based method.

Results:

There was no association of the putative risk genotypes ADH31-1, GSTM1 null and GSTT1 null with HCC (odds ratio [OR], 0.8; 95% confidence interval [CI], 0.5–1.3; OR, 1.0; 95% CI, 0.6–1.5; OR, 0.8; 95% CI, 0.4–1.4, respectively). A steady increase in HCC risk with increasing alcohol intake, which did not vary according to ADH3 and GSTT1 genotypes, was observed. Nevertheless, the OR for HCC due to an alcohol intake of >100 g of ethanol per day increased in subjects with GSTM1 null genotype (OR, 8.5; 95% CI, 3.9–18.6) compared to GSTM1 non-null genotype (OR, 4.5; 95% CI, 2.0–10.0).

Conclusions:

ADH31-1 and GSTT1 null genotypes did not modify the risk of HCC due to alcohol intake whereas an influence of GSTM1 null genotype for high ethanol consumption was suggested.

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Authors and Affiliations

  1. Cattedra di Igiene, Università di Brescia, Italy

    Loredana Covolo, Umberto Gelatti, Paola Trevisi, Michela Franceschini, Giuseppe Nardi & Francesco Donato

  2. Centro di Riferimento Oncologico, Aviano, Italy

    Renato Talamini

  3. Genetics Research Institute, Milano, Italy

    Seymour Garte

  4. International Agency for Research on Cancer, Lyon, France

    Silvia Franceschi

  5. Cattedra di Igiene, DPMSC, Università di Udine, Italy

    Fabio Barbone

  6. Istituto di Virologia, Università di Milano, Italy

    Alessandro Tagger

  7. Istituto di Igiene, Università di Milano, Italy

    Maria Lisa Ribero

  8. Cattedra di Statistica Medica, Università di Brescia, Italy

    Giovanni Parrinello

  9. Unità Operativa di Medicina Interna, Azienda Ospedaliera di Pordenone, Italy

    Valter Donadon

Authors
  1. Loredana Covolo
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  2. Umberto Gelatti
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  3. Renato Talamini
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  6. Silvia Franceschi
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  7. Michela Franceschini
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  9. Alessandro Tagger
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  10. Maria Lisa Ribero
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  13. Giuseppe Nardi
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  14. Francesco Donato
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Corresponding author

Correspondence to Umberto Gelatti.

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Covolo, L., Gelatti, U., Talamini, R. et al. Alcohol Dehydrogenase 3, Glutathione S-transferase M1 and T1 Polymorphisms, Alcohol Consumption and Hepatocellular Carcinoma (Italy). Cancer Causes Control 16, 831–838 (2005). https://doi.org/10.1007/s10552-005-2302-2

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  • DOI: https://doi.org/10.1007/s10552-005-2302-2

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