Abstract
HyperArc™ is a stereotactic radiotherapy modality designed for targeting multiple brain metastases using a single isocenter with multiple non-coplanar arcs. This study aimed to assess the efficacy of two patient-specific quality assurance methods, film and the Varian Portal Dosimetry System with Varian’s HyperArc™ technique and raise important considerations in the customisation of patient-specific quality assurance to accommodate HyperArc™ delivery. Assessment criteria included gamma analysis and mean dose at full width half maximum. The minimum metastasis size, maximum off-axis distance and suitable energy were identified and validated. Patient-specific quality assurance procedures were applied to a range of clinically relevant brain metastasis plans. Initial investigation into energy selection showed no significant differences in gamma pass rates using 6MV, 6MV FFF, or 10MV FFF for metastasis sizes greater than 15 mm diameter at the isocenter. Gamma pass rates (2%/2mm) for 15 mm metastases at the isocenter for all energies were greater than 96.0% for portal dosimetry and greater than 98.7% for film. Fields of size 15 mm placed at various distances (10–70 mm) from the isocenter resulted in a maximum mean dose difference of 1.5% between film and planned. Clinically relevant plans resulted in a maximum mean dose difference for selected metastases of 1.0% between film and plan and a maximum point dose difference of 2.9% between portal dose and plan. Portal dose image prediction was a quick and convenient quality assurance tool for metastases larger than 15 mm near the isocenter but provided diminished geometrical relevance for off-axis metastases. Film QA required exacting procedures but offered the ability to assess the accuracy of geometrical targeting for off-axis metastases and provided dosimetric accuracy for metastases to well below 15 mm diameter.
Similar content being viewed by others
Notes
Icon Cancer Care, Gold Coast University Hospital, QLD, Australia.
ICON Cancer Care, Epworth, Vic, Australia.
References
Schouten LJ, Rutten J, Huveneers HAM, Twijnstra A (2002) Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer. https://doi.org/10.1002/cncr.10541
Soffietti R et al (2017) Diagnosis and treatment of brain metastases from solid tumors: Guidelines from the European Association of neuro-oncology (EANO). Neuro Oncol 19(2):162–174. https://doi.org/10.1093/neuonc/now241
Zhao B, Jin J, Wen N, Huang Y, Siddiqui MS (2014) Prescription to 50–75% isodose line may be optimum for linear accelerator based radiosurgery of cranial lesions. J Radiosurg SBRT 3(2):139–147
Yamamoto M et al (2014) Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study. Lancet Oncol. https://doi.org/10.1016/S1470-2045(14)70061-0
Scoccianti S et al (2015) Organs at risk in the brain and their dose-constraints in adults and in children: a radiation oncologist’s guide for delineation in everyday practice. Radiother Oncol. https://doi.org/10.1016/j.radonc.2015.01.016
Alongi F et al (2016) Stereotactic radiosurgery for intracranial metastases: linac-based and gamma-dedicated unit approach. Expert Rev Anticancer Ther 16(7):731–740. https://doi.org/10.1080/14737140.2016.1190648
Pudsey L et al (2022) Current status of intra-cranial stereotactic radiotherapy and stereotactic radiosurgery in Australia and New Zealand: key considerations from a workshop and surveys. Phys Eng Sci Med 45(1):251–259. https://doi.org/10.1007/s13246-022-01108-4
“Gamma Knife | EdCaN. https://www.edcan.org.au/edcan-learning-resources/supporting-resources/radiotherapy/treatment-delivery/gamma-knife . Accessed 18 July 2021
Reyes DK, Pienta KJ (2015) The biology and treatment of oligometastatic cancer. Oncotarget 6(11):8491. https://doi.org/10.18632/ONCOTARGET.3455
Snyder KC, Xhaferllari I, Huang Y, Siddiqui MS, Chetty IJ, Wen N (2018) Evaluation and verification of the QFix EncompassTM couch insert for intracranial stereotactic radiosurgery. J Appl Clin Med Phys 19(4):222–229. https://doi.org/10.1002/acm2.12387
Varian Medical Systems, “TrueBeam STx System,” (2015). https://varian.force.com/servlet/servlet.FileDownload?retURL=%2Fapex%2FCpEventPresList%3Fid%3Da0OE000000pZaMdMAK&file=00PE000000VdZ5OMAV
Solberg TD et al (2012) Quality and safety considerations in stereotactic radiosurgery and stereotactic body radiation therapy: executive summary. Pract Radiat Oncol 2(1):2–9. https://doi.org/10.1016/J.PRRO.2011.06.014
Halvorsen PH et al (2017) AAPM-RSS medical physics practice guideline 9.a. for SRS-SBRT. J Appl Clin Med Phys 18(5):10–21. https://doi.org/10.1002/ACM2.12146
Palmans H, Andreo P, Huq MS, Seuntjens J, Christaki KE, Meghzifene A (2018) Dosimetry of small static fields used in external photon beam radiotherapy: Summary of TRS-483, the IAEA–AAPM international Code of Practice for reference and relative dose determination. Med Phys 45(11):e1123–e1145. https://doi.org/10.1002/mp.13208
Borca VC et al (2013) Dosimetric characterization and use of GAFCHROMIC EBT3 film for IMRT dose verification. J Appl Clin Med Phys. https://doi.org/10.1120/jacmp.v14i2.4111
Nguyen D, Josserand Pietri F, Hajji Z, Fafi S, Khodri M (2013) Evaluation of varian portal dose image prediction (PDIP) ‘pre-configuration 10’ package for volumetric modulated arc therapy (VMAT) treatments. Phys Medica 29:e21. https://doi.org/10.1016/j.ejmp.2013.08.069
Howard ME, Herman MG, Grams MP (2020) Methodology for radiochromic film analysis using FilmQA Pro and ImageJ. PLoS ONE 15(5):e0233562. https://doi.org/10.1371/JOURNAL.PONE.0233562
Varian (2017) Eclipse Photon and Electron Algorithms 15.5 Reference Guide Document, no
Miri N, Keller P, Zwan BJ, Greer P (2016) EPID-based dosimetry to verify IMRT planar dose distribution for the aS1200 EPID and FFF beams. J Appl Clin Med Phys 17(6):292–304. https://doi.org/10.1120/JACMP.V17I6.6336
Barnes MP, Greer PB (2017) Evaluation of the TrueBeam machine performance check (MPC) beam constancy checks for flattened and flattening filter-free (FFF) photon beams. J Appl Clin Med Phys 18:139–150. https://doi.org/10.1002/acm2.12016
Palmer AL, Dimitriadis A, Nisbet A, Clark CH (2015) Evaluation of Gafchromic EBT-XD film, with comparison to EBT3 film, and application in high dose radiotherapy verification. Phys Med Biol. https://doi.org/10.1088/0031-9155/60/22/8741
LAP LASER, "EASY CUBE, Water-Equivalent Multi-Modul Ar Phantom for QA in RT”, https://www.lap-laser.com/products/easy-cube/ . Accessed 18 Oct 2022
Kulmala A, Ikonen T, Pyyry J, Tenhunen M (2018) Quality assurance of HyperArc TM radiotherapy using a robust film dosimetry protocol. https://doi.org/10.3252/pso.eu.ESTRO37.2018
Lewis D, Micke A, Yu X, Chan MF (2012) An efficient protocol for radiochromic film dosimetry combining calibration and measurement in a single scan. Med Phys. https://doi.org/10.1118/1.4754797
Wen N et al (2016) Precise film dosimetry for stereotactic radiosurgery and stereotactic body radiotherapy quality assurance using Gafchromic™ EBT3 films. Radiat Oncol. https://doi.org/10.1186/s13014-016-0709-4
Mathot M, Sobczak S, Hoornaert MT (2014) Gafchromic film dosimetry: four years experience using FilmQA Pro software and Epson flatbed scanners. Phys Medica 30(8):871–877. https://doi.org/10.1016/j.ejmp.2014.06.043
Micke A, Lewis D, Yu X (2011) SU-E-I-63: multi-channel film dosimetry with non-uniformity correction. Med Phys 38:3410. https://doi.org/10.1118/1.3611636
Lewis D, Devic S (2015) Correcting scan-to-scan response variability for a radiochromic film-based reference dosimetry system. Med Phys 42(10):5692–5701. https://doi.org/10.1118/1.4929563
Calvo-Ortega J-F, Moragues-Femenía S, Laosa-Bello C, José-Maderuelo SS, Casals-Farran J (2019) A closer look at the conventional Winston-Lutz test: analysis in terms of dose. Rep Pract Oncol Radiother 24(5):421. https://doi.org/10.1016/J.RPOR.2019.07.003
Klein EE et al (2009) Task group 142 report: quality assurance of medical acceleratorsa. Med Phys 36(9):4197–4212. https://doi.org/10.1118/1.3190392
Li Y, Chen L, Zhu J, Liu X (2017) The combination of the error correction methods of GAFCHROMIC EBT3 film. PLoS ONE. https://doi.org/10.1371/journal.pone.0181958
Miura H et al (2016) Gafchromic EBT-XD film: dosimetry characterization in high-dose, volumetric-modulated arc therapy. J Appl Clin Med Phys. https://doi.org/10.1120/jacmp.v17i6.6281
Lewis DF, Chan MF (2016) Technical Note: on GAFChromic EBT-XD film and the lateral response artifact. Med Phys. https://doi.org/10.1118/1.4939226
Miften M et al (2018) Tolerance limits and methodologies for IMRT measurement-based verification QA: recommendations of AAPM Task Group No. 218. Med Phys 45(4):e53–e83. https://doi.org/10.1002/MP.12810
Bresciani S et al (2018) Comparison of two different EPID-based solutions performing pretreatment quality assurance: 2D portal dosimetry versus 3D forward projection method. Phys Medica 52:65–71. https://doi.org/10.1016/J.EJMP.2018.06.005
Crowe SB et al (2016) Technical Note: Relationships between gamma criteria and action levels: results of a multicenter audit of gamma agreement index results. Med Phys 43(3):1501–1506. https://doi.org/10.1118/1.4942488
Smith A, Kim S, Serago C, Hintenlang K, Hintenlang D, Heckman M (2015) Use of flattening filter free photon beams for off-axis targets in conformal arc stereotactic body radiation therapy. IFMBE Proc 51(4):448–451. https://doi.org/10.1007/978-3-319-19387-8_109
Acknowledgements
I would like to thank my employer ICON for the opportunity to be part of an exciting project where the benefits are seen in the hope of the patients. Lastly and most importantly, I would like to thank Emmanuel Baveas for his relentless, patient input that has led me to this final word.
Funding
The authors declare that no funds, grants, or other support were received during the preparation of this manuscript. The authors have no relevant financial or non-financial interests to disclose.
Author information
Authors and Affiliations
Contributions
All authors contributed to the study’s conception and design. Material preparation, data collection and analysis were performed by OK, and PD. The first draft of the manuscript was written by OK, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Competing interests
The authors have no relevant financial or non-financial interests to disclose.
Ethical approval
This research was conducted without the need for 321.2227 human or animal involvement and consequently did not require ethics approval.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Kamst, O., Desai, P. Evaluation of HyperArc™ using film and portal dosimetry quality assurance. Phys Eng Sci Med 46, 57–66 (2023). https://doi.org/10.1007/s13246-022-01197-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13246-022-01197-1