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Verification of lithium formate monohydrate in 3D-printed container for electron paramagnetic resonance dosimetry in radiotherapy

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Abstract

The nondestructive dosimetry achieved with electron paramagnetic resonance (EPR) dosimetry facilitates repetitive recording by the same dosimeter to increase the reliability of data. In precedent studies, solid paraffin was needed as a binder material to make the lithium formate monohydrate (LFM) EPR dosimeter stable and nonfragile; however, its use complicates dosimetry. This study proposes a newly designed pure LFM EPR dosimeter created by inserting LFM into a 3D-printed container. Dosimetric characteristics of the LFM EPR dosimeter and container, such as reproducibility, linearity, energy dependence, and angular dependence, were evaluated and verified through a radiation therapy planning system (RTPS). The LFM EPR dosimeters were irradiated using a clinical linear accelerator. The EPR spectra of the dosimeters were acquired using a Bruker EMX EPR spectrometer. Through this study, it was confirmed that there is no tendency in the EPR response of the container based on irradiation dose or radiation energy. The results show that the LFM EPR dosimeters have a highly sensitive dose response with good linearity. The energy dependence across each photon and electron energy range seems to be negligible. Based on these results, LFM powder in a 3D-printed container is a suitable option for dosimetry of radiotherapy. Furthermore, the LFM EPR dosimeter has considerable potential for in vivo dosimetry and small-field dosimetry via additional experiments, owing to its small effective volume and highly sensitive dose response compared with a conventional dosimeter.

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References

  1. Kim J-N, Lee Y-K, Shin H-J, Ji S-H, Park S-K, Kim J-Y, Kang Y-N (2016) Development of deformable moving lung phantom to simulate respiratory motion in radiotherapy. Med Dosim 41(2):113–117

    Article  PubMed  Google Scholar 

  2. Shin H-J, Kim M-H, Choi I-B, Kang Y-N, Kim D-H, Choi B-O, Jang H-S, Jung J-Y, Son S-H, Kay C-S (2013) Evaluation of the EDGE detector in small-field dosimetry. J Korean Phys Soc 63(1):128–134

    Article  CAS  Google Scholar 

  3. Shin H-J, Kim S-W, Kay C-S, Seo J-H, Lee G-W, Kang K-M, Kang Y-N (2015) Evaluation of the Elekta Symmetry™ 4D IGRT system by using a moving lung phantom. J Korean Phys Soc 67(1):260–263

    Article  Google Scholar 

  4. Shin H-J, Song J-H, Jung J-Y, Kwak Y-K, Kay C-S, Kang Y-N, Son S-H (2013) Advantage of 3D volumetric dosemeter in delivery quality assurance of dynamic arc therapy: comparison of pencil beam and Monte Carlo calculations. Br J Radiol 86(1032):20130353

    Article  PubMed  PubMed Central  Google Scholar 

  5. Essers M, Mijnheer B (1999) In vivo dosimetry during external photon beam radiotherapy. Int J Radiat Oncol Biol Phys 43(2):245–259

    Article  CAS  PubMed  Google Scholar 

  6. Kron T (1994) Thermoluminescence dosimetry and its applications in medicine–Part 1: Physics, materials and equipment. Australas Phys Eng Sci Med 17(4):175–199

    CAS  PubMed  Google Scholar 

  7. Rah J-E, Hong J-Y, Kim G-Y, Kim Y-L, Shin D-O, Suh T-S (2009) A comparison of the dosimetric characteristics of a glass rod dosimeter and a thermoluminescent dosimeter for mailed dosimeter. Radiat Meas 44(1):18–22

    Article  CAS  Google Scholar 

  8. Bougai A, Brik A, Chumak V, Desrosiers M, Dubovski S, Fattibene P, Onori S (2002) Use of electron paramagnetic resonance dosimetry with tooth enamel for retrospective dose assessment. Vienna International Centre, Austria

    Google Scholar 

  9. Schaeken B, Scalliet P (1996) One year of experience with alanine dosimetry in radiotherapy. Appl Radiat Isot 47(11–12):1177–1182

    Article  CAS  PubMed  Google Scholar 

  10. Ciesielski B, Schultka K, Kobierska A, Nowak R, Peimel-Stuglik Z (2003) In vivo alanine/EPR dosimetry in daily clinical practice: a feasibility study. Int J Radiat Oncol Biol Phys 56(3):899–905

    Article  PubMed  Google Scholar 

  11. Nagy V, Sholom S-V, Chumak V-V, Desrosiers M-F (2002) Uncertainties in alanine dosimetry in the therapeutic dose range. Appl Radiat Isot 56(6):917–929

    Article  CAS  Google Scholar 

  12. Hayes R-B, Haskell E-H, Wieser A, Romanyukha A-A, Hardy BL, Barrus J-K (2000) Assessment of an alanine EPR dosimetry technique with enhanced precision and accuracy. Nucl Instrum Methods Phys Res A 440(2):453–461

    Article  CAS  Google Scholar 

  13. Vestad T-A, Malinen E, Lund A, Hole E-O, Sagstuen E (2003) EPR dosimetric properties of formates. Appl Radiat Isot 59(2–3):181–188

    Article  CAS  PubMed  Google Scholar 

  14. Lund E, Gustafsson H, Danilczuk M, Sastry M, Lund A, Vestad T, Malinen E, Hole E, Sagstuen E (2005) Formates and dithionates: sensitive EPR-dosimeter materials for radiation therapy. Appl Radiat Isot 62(2):317–324

    Article  CAS  PubMed  Google Scholar 

  15. Vestad T-A, Malinen E, Olsen D-R, Hole E-O, Sagstuen E (2004) Electron paramagnetic resonance (EPR) dosimetry using lithium formate in radiotherapy: comparison with thermoluminescence (TL) dosimetry using lithium fluoride rods. Phys Med Biol 49(20):4701

    Article  CAS  PubMed  Google Scholar 

  16. Thomas J-O, Tellgren R, Almlöf J (1975) Hydrogen bond studies. XCVI. X-N maps and ab initio MO–LCAO–SCF calculations of the difference electron density in noncentrosymmetric lithium formate monohydrate, LiHCOO H2O. Acta Crystallogr A 31(7):1946–1955

    Article  Google Scholar 

  17. Antonovic L, Gustafsson H, Carlsson GA, Tedgren ÅC (2009) Evaluation of a lithium formate EPR dosimetry system for dose measurements around brachytherapy sources. Med Phys 36(6Part1):2236–2247

    Article  CAS  PubMed  Google Scholar 

  18. Vestad T-A, Gustafsson H, Lund A, Hole E-O, Sagstuen E (2004) Radiation-induced radicals in lithium formate monohydrate (LiHCO 2· H 2 O). EPR and ENDOR studies of X-irradiated crystal and polycrystalline samples. Phys Chem Chem Phys 6(11):3017–3022

    Article  Google Scholar 

  19. Adolfsson E, Carlsson G-A, Grindborg J-E, Gustafsson H, Lund E, Tedgren Å-C (2010) Response of lithium formate EPR dosimeters at photon energies relevant to the dosimetry of brachytherapy. Med Phys 37(9):4946–4959

    Article  CAS  PubMed  Google Scholar 

  20. Yordanov N-D, Fabisiak S, Lagunov O (2006) Effect of the shape and size of dosimeters on the response of solid state/EPR dosimetry. Radiat Meas 41(3):257–263

    Article  CAS  Google Scholar 

  21. Adolfsson E (2014) Lithium formate EPR dosimetry for accurate measurements of absorbed dose in radiotherapy. Doctoral Thesis, Linköping University.

  22. Hayes R-B (2000) Concerns regarding recent NIST publications on alanine dosimetry. Radiat Phys Chem 59:443–444

    Article  CAS  Google Scholar 

  23. Al-Karmi A-M, Ayaz A-A-H, Al-Enezi M-S, Abdel-Rahman W, Dwaikat N (2015) Verification of the pure alanine in PMMA tube dosimeter applicability for dosimetry of radiotherapy photon beams: a feasibility study. Australas Phys Eng Sci Med 38(3):425–434

    Article  PubMed  Google Scholar 

  24. Goldstone KE (1990) Tissue substitutes in radiation dosimetry and measurement. In: ICRU Report 44, International Commission on Radiation Units and Measurements, USA

  25. Malinen E, Waldeland E, Hole E-O, Sagstuen E (2007) The energy dependence of lithium formate EPR dosimeters for clinical electron beams. Phys Med Biol 52(14):4361

    Article  CAS  PubMed  Google Scholar 

  26. Gustafsson H, Lund E, Olsson S (2008) Lithium formate EPR dosimetry for verifications of planned dose distributions prior to intensity-modulated radiation therapy. Phys Med Biol 53(17):4667

    Article  CAS  PubMed  Google Scholar 

  27. Fippel M (1999) Fast Monte Carlo dose calculation for photon beams based on the VMC electron algorithm. Med Phys 26(8):1466–1475

    Article  CAS  PubMed  Google Scholar 

  28. Kawrakow I, Fippel M, Friedrich K (1996) 3D electron dose calculation using a Voxel based Monte Carlo algorithm (VMC). Med Phys 23(4):445–457

    Article  CAS  PubMed  Google Scholar 

  29. Petoukhova A-L, Van Wingerden K, Wiggenraad R-G-J, Van de Vaart P-J-M, Van Egmond J, Franken E-M, Van Santvoort J-P-C (2010) Verification measurements and clinical evaluation of the iPlan RT Monte Carlo dose algorithm for 6 MV photon energy. Phys Med Biol 55(16):4601

    Article  CAS  PubMed  Google Scholar 

  30. Fragoso M, Wen N, Kumar S, Liu D, Ryu S, Movsas B, Chetty I-J (2010) Dosimetric verification and clinical evaluation of a new commercially available Monte Carlo-based dose algorithm for application in stereotactic body radiation therapy (SBRT) treatment planning. Phys Med Biol 55(16):4445

    Article  PubMed  Google Scholar 

  31. Geso M, Ackerly T, Lim S-A, Best S-P, Gagliardi F, Smith C-L (2018) Application of the ‘spiking’ method to the measurement of low dose radiation (≤ 1 Gy) using alanine dosimeters. Appl Radiat Isot 133:111–116

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This research was supported by Advanced Institute For Radiation Fusion Medical Technology (AIRFMT) at Catholic University of Korea.

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Authors and Affiliations

  1. Department of Biomedicine & Health Sciences, The Catholic University of Korea, 222 Banpo Road (Catholic University of Korea), Seocho-gu, Seoul, Korea

    Jin-sol Shin, Hun Joo Shin, Shin Wook Kim, Jina Kim, Aeran Kim, Jinho Hwang, Yunji Seol & Taegeon Oh

  2. Advanced Institute for Radiation Fusion Medical Technology, College of Medicine, The Catholic University of Korea, Annex B1 222 Banpo Road (Catholic University Seoul St. Mary’s Hospital), Seocho-gu, Seoul, Korea

    Jin-sol Shin, Hun Joo Shin, Shin Wook Kim, Hyeong Wook Park, Jina Kim, Aeran Kim, Jinho Hwang, Yunji Seol, Taegeon Oh, Hong Seok Jang, Byung Ock Choi & Young-nam Kang

  3. Department of Radiation Oncology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 59 Dongsu-ro (665-9 Bupyeong-dong), Bupyeong-gu, Incheon, Korea

    Jin-sol Shin, Hun Joo Shin & Shin Wook Kim

  4. Department of Radiation Emergency Medical Team, Radiation Health Institute, 5F/B1F SNUH Health Care Innovation Park B/D, 172, Dolma-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea

    Hoon Choi

  5. Department of Medical Physics, Kyonggi University of Korea, 154-42, Gwanggyosan-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, Korea

    Hyeong Wook Park

  6. Department of Radiation Oncology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul, Republic of Korea

    Hyeong Wook Park

  7. Department of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo Road (Catholic University Seoul St. Mary’s Hospital), Seocho-gu, Seoul, Korea

    Hong Seok Jang, Byung Ock Choi & Young-nam Kang

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  1. Jin-sol Shin
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  2. Hoon Choi
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Correspondence to Young-nam Kang.

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Shin, Js., Choi, H., Shin, H.J. et al. Verification of lithium formate monohydrate in 3D-printed container for electron paramagnetic resonance dosimetry in radiotherapy. Australas Phys Eng Sci Med 42, 811–818 (2019). https://doi.org/10.1007/s13246-019-00786-x

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  • DOI: https://doi.org/10.1007/s13246-019-00786-x

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