Footnotes
We thank Nasun Hah and Ling Ouyang for next-generation sequencing. We thank M. Schwarz for administrative support. We thank Tong Zhang from Salk Biophotonics core. We thank Clinica CEMTRO for the kindly donation of primary human cells. P.M-R and J.P were partially supported by Fundacion Alfonso Martin Escudero. This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16010100), Major Program of Development Fund for Shanghai Zhangjiang National Innovation Demonstration Zone (ZJ2018-ZD-004), the National Natural Science Foundation of China (81625009, 81330008, 91749202), Beijing Municipal Commission of Health and Family Planning (PXM2018_026283_000002). This study was supported by, Fundación Dr. Pedro Guillén, Universidad Católica San Antonio de Murcia (UCAM), Asociación de Futbolistas Españoles (AFE), Fundación Teléfonica, Fundación MAPFRE, The Moxie Foundation and The G. Harold and Leila Y. Mathers Charitable Foundation.
P.M-R, I.G-G and J.C.I.B. designed all the experiments. P.M-R, I.G-G and J.C.I.B. prepared the Figures and wrote the manuscript. P.M-R, I.G-G, J.P., M.K., R.H-B, A.N., T.L., Y.H. and T.H. performed and analyzed in vitro experiments. P.M-R, I.G-G, C.W., F.H., C.Z., C.R., P.R., M.S., and K.S. performed and analyzed in vivo experiments. P.M-R, I.G-G, L.H. and M.S. performed RNA-seq analysis. I.G-V, E.R-I, J.L-A, E.N-D, M.G-V, G.C., JM.C., N.D. P.G., and G.-H.L. provided reagents and helped to conceptualize, coordinate and oversee the study.
Paloma Martinez-Redondo, Isabel Guillen-Guillen, Noah Davidshon, Chao Wang, Javier Prieto, Masakazu Kurita, Fumiyuki Hatanaka, Cuiqing Zhong, Reyna Hernandez-Benitez, Tomoaki Hishida, Takashi Lezaki, Akihisa Sakamoto, Amy N. Nemeth, Yuriko Hishida, Concepcion Rodriguez-Esteban, Kensaku Shojima, Ling Huang, Maxim Nikolaievich Shokhirev, Estrella Nuñez-Delicado, Josep M. Campistol, Isabel Guillen-Vicente, Elena Rodriguez-Iñigo, Juan Manuel Lopez-Alcorocho, Marta Guillen-Vicente, Pedro Guillen-Garcia, George Church, Pradeep Reddy, Juan Carlos Izpisua-Belmonte declare that they have no conflict of interest. All institutional and national guidelines for the care and use of laboratory animals were followed.