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Sustained-Released Formulation of Nifedipine Solid Dispersion with Various Polymers

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Abstract

Nifedipine is a calcium channel blocker widely used for the treatment of blood pressure related diseases such as angina, hypertension and Raynaud. However, since the drug after the administration reaches the highest blood concentration between 30 min and 2 h, its insolubility may expose the patient to various side effects. In this study, nifedipine was prepared as a solid dispersion using a water-soluble polymer (PVP-K30) in order to increase the releasing time and postpone the time at which the drug reaches its highest concentration, thereby increasing its bioavailability. SEM, XRD, DSC, and FT-IR were used for characterization of the solid dispersion. In order to test the release of the drug, a dissolution test was performed with a serous fluid for 12 h. In this work a drug formulation capable of sustained release of nifedipine using a water-soluble polymer was developed.

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Author notes

  1. These authors equally contributed to this work.

Authors and Affiliations

  1. Department of BIN Convergence Technology, Department of Polymer Nano Science & Technology and Polymer Materials Fusion Research Center, Chonbuk National University, Deokjin-gu, Jeonju, 561-756, Korea

    Won Kyung Kim, Jin Su Kim, Myeong Eun Shin, Jong Seon Baek, David Kim, Jeong Eun Song & Gilson Khang

  2. Department of Industrial Engineering, University of Trento, via Sommarive 9, Trento, Italy

    Alessio Bucciarelli

  3. BIOTech Research Center, University of Trento, via delle Regole 101, Trento, Italy

    Alessio Bucciarelli

  4. European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Trento, Italy

    Alessio Bucciarelli

Authors
  1. Won Kyung Kim
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  2. Jin Su Kim
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  3. Myeong Eun Shin
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  4. Jong Seon Baek
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  5. David Kim
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  6. Alessio Bucciarelli
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  8. Gilson Khang
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Correspondence to Gilson Khang.

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Acknowledgments: This research was supported by the International Research & Development Program through the National Research Foundation of Korea (NRF-2017K1A3A7A03089427) and a grant of the Korea Health Technology R&D Project (HI15C2996) through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea.

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Kim, W.K., Kim, J.S., Shin, M.E. et al. Sustained-Released Formulation of Nifedipine Solid Dispersion with Various Polymers. Macromol. Res. 28, 553–557 (2020). https://doi.org/10.1007/s13233-020-8099-8

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  • DOI: https://doi.org/10.1007/s13233-020-8099-8

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