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Application of nanomaterials for imaging pancreatic islets

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Abstract

While pancreatic islet transplantation has emerged as one of the most promising therapies for diabetes mellitus, determining the fate of islet grafts remains a challenge. Transplanted islets are damaged by hypoxic stress and immune responses in the period shortly following transplantation. Understanding the mechanisms of islet graft loss is difficult without real-time monitoring in vivo. Recently, nanotechnology has emerged in studies of biomedical imaging. Nanoparticles can enhance the versatility of different imaging modalities. Moreover, nanoparticles provide potential probes to image transplanted islets by optical imaging, magnetic resonance imaging and positron emission tomography. The nanoparticles are delivered to islet grafts using different methods, such as non-specific uptake, conjugation to the islet membranes and targeting to a membrane receptor or transporter. If applied clinically, these methods would provide information about the viability and function of transplanted islets, which will enhance graft survival. This review focuses on recent advances in nanoparticles for in vivo imaging of islet transplantation.

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References

  1. D. K. Andersen, Diabetes Metab. Res. Rev., 28, 326 (2012).

    Article  Google Scholar 

  2. N. Ewald, C. Kaufmann, A. Raspe, H. U. Kloer, R. G. Bretzel, and P. D. Hardt, Diabetes Metab. Res. Rev., 28, 338 (2012).

    Article  CAS  Google Scholar 

  3. A. M. J. Shapiro, J. R. T. Lakey, E. A. Ryan, G. S. Korbutt, E. Toth, G. L. Warnock, N. M. Kneteman, and R. V. Rajotte, N. Engl. J. Med., 343, 230 (2000).

    Article  CAS  Google Scholar 

  4. E. A. Ryan, B. W. Paty, P. A. Senior, D. Bigam, E. Alfadhli, N. M. Kneteman, J. R. T. Lakey, and A. M. J. Shapir, Diabetes, 54, 2060 (2005).

    Article  CAS  Google Scholar 

  5. A. M. J. Shapiro, C. Ricordi, B. J. Hering, H. Auchincloss, R. Lindblad, P. Robertson, A. Secchi, M. D. Brendel, T. Berney, D. C. Brennan, E. Cagliero, R. Alejandro, E. A. Ryan, B. DiMercurio, P. Morel, K. S. Polonsky, J. A. Reems, R. G. Bretzel, F. Bertuzzi, T. Froud, R. Kandaswamy, D. E. R. Sutherland, G. Eisenbarth, M. Segal, J. Preiksaitis, G. S. Korbutt, F. B. Barton, L. Viviano, V. Seyfert-Margolis, J. Bluestone, and J. R. T. Lakey, N. Engl. J. Med., 355, 1318 (2006).

    Article  CAS  Google Scholar 

  6. N. Sakata, P. Hayes, A. Tan, N. K. Chan, J. Mace, R. Peverini, L. Sowers, W. J. Pearce, R. Chinnock, A. Obenaus, and E. Hathout, Transplantation, 87, 825 (2009).

    Article  Google Scholar 

  7. H. Johansson, A. Lukinius, L. Moberg, T. Lundgren, C. Berne, A. Foss, M. Felldin, R. Kallen, K. Salmela, A. Tibe, G. Tufveson, K. N. Ekdahl, G. Elgue, O. Korsgren, and B. Nilsson, Diabetes, 54, 1755 (2005).

    Article  CAS  Google Scholar 

  8. R. C. S. Ayres, B. Dousset, S. Wixon, J. A. C. Buckels, P. Mcmaster, and A. D. Mayer, Lancet, 343, 862 (1994).

    Article  CAS  Google Scholar 

  9. F. Berthoux, Nephrol. Dial. Transplant., 17, 2 (2002).

    Article  Google Scholar 

  10. M. Pascual, T. Theruvath, T. Kawai, N. Tolkoff-Rubin, and A. B. Cosimi, N. Engl. J. Med., 346, 580 (2002).

    Article  Google Scholar 

  11. Y. X. Lu, H. Dang, B. Middleton, Z. Zhang, L. Washburn, M. Campbell-Thompson, M. A. Atkinson, S. S. Gambhir, J. Tian, and D. L. Kaufman, Mol. Ther., 9, 428 (2004).

    Article  CAS  Google Scholar 

  12. X. J. Chen, X. M. Zhang, C. S. Larson, M. S. Baker, and D. B. Kaufman, Transplantation, 81, 1421 (2006).

    Article  Google Scholar 

  13. J. Virostko, A. Radhika, G. Poffenberger, Z. Y. Chen, M. Brissova, J. Gilchrist, B. Coleman, M. Gannon, E. D. Jansen, and A. C. Powers, Mol. Imaging Biol., 12, 42 (2010).

    Article  Google Scholar 

  14. T. F. Massoud and S. S. Gambhir, Genes Dev., 17, 545 (2003).

    Article  CAS  Google Scholar 

  15. Y. X. Lu, H. Dang, B. Middleton, M. Campbell-Thompson, M. A. Atkinson, S. S. Gambhir, J. Tian, and D. L. Kaufman, Mol. Ther., 14, 851 (2006).

    Article  CAS  Google Scholar 

  16. D. L. Huber, Small, 1, 482 (2005).

    Article  CAS  Google Scholar 

  17. A. Ito, M. Shinkai, H. Honda, and T. Kobayashi, J. Biosci. Bioeng., 100, 1 (2005).

    Article  CAS  Google Scholar 

  18. A. Elias and A. Tsourkas, Hematology/The Education Program of the American Society of Hematology, American Society of Hematology, Education Program, 720 (2009).

    Google Scholar 

  19. Y. H. Hwang and D. Y. Lee, Quantitative Imaging in Medicine and Surgery, 2, 118 (2012).

    Google Scholar 

  20. C. Sun, J. S. Lee, and M. Zhang, Adv. Drug Deliv. Rev., 60, 1252 (2008).

    Article  CAS  Google Scholar 

  21. J. R. McCarthy and R. Weissleder, Adv. Drug Deliv. Rev., 60, 1241 (2008).

    Article  CAS  Google Scholar 

  22. S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, L. Vander Elst, and R. N. Muller, Chem. Rev., 108, 2064 (2008).

    Article  CAS  Google Scholar 

  23. Y. X. Wang, S. M. Hussain, and G. P. Krestin, Eur. Radiol., 11, 2319 (2001).

    Article  CAS  Google Scholar 

  24. B. Bonnemain, J. Drug Target., 6, 167 (1998).

    Article  CAS  Google Scholar 

  25. M. G. Harisinghani, J. Barentsz, P. F. Hahn, W. M. Deserno, S. Tabatabaei, C. H. van de Kaa, J. de la Rosette, and R. Weissleder, N. Engl. J. Med., 348, 2491 (2003).

    Article  Google Scholar 

  26. N. V. Evgenov, Z. Medarova, G. Dai, S. Bonner-Weir, and A. Moore, Nat. Med., 12, 144 (2006).

    Article  CAS  Google Scholar 

  27. J. M. Veranth, E. G. Kaser, M. M. Veranth, M. Koch, and G. S. Yost, Particle Fibre Toxicology, 4, 2 (2007).

    Article  Google Scholar 

  28. U. O. Hafeli, J. S. Riffle, L. Harris-Shekhawat, A. Carmichael- Baranauskas, F. Mark, J. P. Dailey, and D. Bardenstein, Mol. Pharm., 6, 1417 (2009).

    Article  CAS  Google Scholar 

  29. H. A. Jeng and J. Swanson, J. Environ. Sci. Health A Tox. Hazard. Subst. Environ. Eng., 41, 2699 (2006).

    Article  CAS  Google Scholar 

  30. S. M. Hussain, K. L. Hess, J. M. Gearhart, K. T. Geiss, and J. J. Schlager, Toxicol. In Vitro, 19, 975 (2005).

    Article  CAS  Google Scholar 

  31. Y. Jiao, Z. H. Peng, J. Y. Zhang, J. Qin, and C. P. Zhong, Transplant. Proc., 40, 3615 (2008).

    Article  CAS  Google Scholar 

  32. L. L. Yang, X. H. Peng, Y. A. Wang, X. X. Wang, Z. H. Cao, C. C. Ni, P. Karna, X. J. Zhang, W. C. Wood, X. H. Gao, S. M. Nie, and H. Mao, Clin. Cancer Res., 15, 4722 (2009).

    Article  CAS  Google Scholar 

  33. J. H. Juang, J. J. Wang, C. R. Shen, C. H. Kuo, Y. W. Chien, H. Y. Kuo, Z. T. Tsai, and T. C. Yen, Transplant. Proc., 42, 2104 (2010).

    Article  CAS  Google Scholar 

  34. M. T. Klepka, N. Nedelko, J. M. Greneche, K. Lawniczak- Jablonska, I. N. Demchenko, A. Slawska-Waniewska, C. A. Rodrigues, A. Debrassi, and C. Bordini, Biomacromolecules, 9, 1586 (2008).

    Article  CAS  Google Scholar 

  35. M. J. Laudenslager, J. D. Schiffman, and C. L. Schauer, Biomacromolecules, 9, 2682 (2008).

    Article  CAS  Google Scholar 

  36. J. Zhang, Q. Wang, L. Wang, and A. Wang, Carbon, 45, 1917 (2007).

    Article  CAS  Google Scholar 

  37. Z. T. Tsai, J. F. Wang, H. Y. Kuo, C. R. Shen, J. J. Wang, and T. C. Yen, J. Magn. Magn. Mater., 322, 208 (2010).

    Article  CAS  Google Scholar 

  38. J. A. Frank, B. R. Miller, A. S. Arbab, H. A. Zywicke, E. K. Jordan, B. K. Lewis, L. H. Bryant, and J. W. M. Bulte, Radiology, 228, 480 (2003).

    Article  Google Scholar 

  39. Z. L. Zhang, E. J. van den Bos, P. A. Wielopolski, M. de Jong-Popijus, D. J. Duncker, and G. P. Krestin, Magn. Reson. Mater. Phys. Biol. Med., 17, 201 (2004).

    Article  CAS  Google Scholar 

  40. B. Yang, H. L. Cai, W. J. Qin, B. Zhang, C. X. Zhai, B. Jiang, and Y. L. Wu, Int. J. Nanomed., 8, 3977 (2013).

    Google Scholar 

  41. S. J. Kim, C. L. Nian, S. Widenmaier, and C. H. S. McIntosh, Mol. Cell. Biol., 28, 1644 (2008).

    Article  CAS  Google Scholar 

  42. H. Iwahashi, T. Hanafusa, Y. Eguchi, H. Nakajima, J. Miyagawa, N. Itoh, K. Tomita, M. Namba, M. Kuwajima, T. Noguchi, Y. Tsujimoto, and Y. Matsuzawa, Diabetologia, 39, 530 (1996).

    Article  CAS  Google Scholar 

  43. L. Aguilar-Bryan, J. P. Clement, G. Gonzalez, K. Kunjilwar, A. Babenko, and J. Bryan, Physiol. Rev., 78, 227 (1998).

    CAS  Google Scholar 

  44. P. Proks, F. Reimann, N. Green, F. Gribble, and F. Ashcroft, Diabetes, 51, S368 (2002).

    Article  CAS  Google Scholar 

  45. M. Schwanstecher, C. Schwanstecher, C. Dickel, F. Chudziak, A. Moshiri, and U. Panten, Brit. J. Pharmacol., 113, 903 (1994).

    Article  CAS  Google Scholar 

  46. S. Schneider, P. J. Feilen, M. Schreckenberger, M. Schwanstecher, C. Schwanstecher, H.G. Buchholz, O. Thews, K. Oberholzer, A. Korobeynikov, A. Bauman, S. Comagic, M. Piel, E. Schirrmacher, C. Y. Shiue, A. A. Alavi, P. Bartenstein, F. Rosch, M. M. Weber, H. H. Klein, and R. Schirrmacher, Exp. Clin. Endocrinol. Diabetes, 113, 388 (2005).

    Article  CAS  Google Scholar 

  47. S. Schneider, S. Ueberberg, A. Korobeynikov, W. Schechinger, C. Schwanstecher, M. Schwanstecher, H. H. Klein, and E. Schirrmacher, Regul. Pept., 139, 122 (2007).

    Article  CAS  Google Scholar 

  48. M. Schottelius, H. J. Wester, J. C. Reubi, R. Senekowitsch-Schmidtke, and M. Schwaiger, Bioconjug. Chem., 13, 1021 (2002).

    Article  CAS  Google Scholar 

  49. Y. F. Zhang and W. G. Chen, Nucl. Med. Commun., 33, 223 (2012).

    Article  Google Scholar 

  50. J. J. Holst, C. F. Deacon, T. Vilsboll, T. Krarup, and S. Madsbad, Trends. Mol. Med., 14, 161 (2008).

    Article  CAS  Google Scholar 

  51. C. F. Deacon, A. H. Johnsen, and J. J. Holst, J. Clin. Endocr. Metab., 80, 952 (1995).

    CAS  Google Scholar 

  52. Z. H. Wu, S. L. Liu, I. Nair, K. Omori, S. Scott, I. Todorov, J. E. Shively, P. S. Conti, Z. B. Li, and F. Kandeel, Theranostics, 4, 770 (2014).

    Article  CAS  Google Scholar 

  53. Z. H. Wu, S. L. Liu, M. Hassink, I. Nair, R. Park, L. Li, I. Todorov, J. M. Fox, Z. B. Li, J. E. Shively, P. S. Conti, and F. Kandeel, J. Nucl. Med., 54, 244 (2013).

    Article  CAS  Google Scholar 

  54. Z. Wu, I. Todorov, L. Li, J. R. Bading, Z. B. Li, I. Nair, K. Ishiyama, D. Cocher, P. E. Conti, S. E. Fraser, J. E. Shively, and F. Kandeel, Bioconjug. Chem., 22, 1587 (2011).

    Article  CAS  Google Scholar 

  55. M. Brom, W. Woliner-van der Weg, L. Joosten, C. Frielink, T. Bouckenooghe, P. Rijken, K. Andralojc, B. J. Goke, M. de Jong, D. L. Eizirik, M. Behe, T. Lahoutte, W. J. G. Oyen, C. J. Tack, M. Janssen, O. C. Boerman, and M. Gotthardt, Diabetologia, 57, 950 (2014).

    Article  CAS  Google Scholar 

  56. M. Brom, L. Joosten, W. J. G. Oyen, M. Gotthardt, and O. C. Boerman, Contrast Media Mol. Imaging, 7, 160 (2012).

    Article  CAS  Google Scholar 

  57. Y. Wang, K. Lim, M. Normandin, X. J. Zhao, G. W. Cline, and Y. S. Ding, Nucl. Med. Biol., 39, 167 (2012).

    Article  CAS  Google Scholar 

  58. B. Zhang, B. Yang, C. X. Zhai, B. Jiang, and Y. L. Wu, Biomaterials, 34, 5843 (2013).

    Article  CAS  Google Scholar 

  59. C. Brand, D. Abdel-Atti, Y. C. Zhang, S. Carlin, S. M. Clardy, E. J. Keliher, W. A. Weber, J. S. Lewis, and T. Reiner, Bioconjug. Chem., 25, 1323 (2014).

    Article  CAS  Google Scholar 

  60. W. J. Malaisse, Diabetologia, 44, 393 (2001).

    Article  CAS  Google Scholar 

  61. M. Srinivas, A. Heerschap, E. T. Ahrens, C. G. Figdor, and I. J. de Vries, Trends Biotechnol., 28, 363 (2010).

    Article  CAS  Google Scholar 

  62. W. J. Malaisse, Y. Zhang, K. Louchami, S. Sharma, T. Dresselaers, U. Himmelreich, G. W. Novotny, T. Mandrup-Poulsen, D. Waschke, Y. Leshch, J. Thimm, J. Thiem, and A. Sener, Arch. Biochem. Biophys., 517, 138 (2012).

    Article  CAS  Google Scholar 

  63. C. Ran, P. Pantazopoulos, Z. Medarova, and A. Moore, Angew. Chem. Int. Ed. Engl., 46, 8998 (2007).

    Article  CAS  Google Scholar 

  64. Z. Wang and H. Gleichmann, Diabetes, 47, 50 (1998).

    Article  CAS  Google Scholar 

  65. R. H. Duncan and G. S. Davies, Int. J. Quantum Chem., 35, 665 (1989).

    Article  CAS  Google Scholar 

  66. K. Oishi, Y. Miyamoto, H. Saito, K. Murase, K. Ono, M. Sawada, M. Watanabe, Y. Noguchi, T. Fujiwara, S. Hayashi, and H. Noguchi, PloS One, 8, e57046 (2013).

    Article  CAS  Google Scholar 

  67. F. Ris, M. Lepetit-Coiffe, P. Meda, L. A. Crowe, C. Toso, M. Armanet, N. Niclauss, G. Parnaud, L. Giovannoni, D. Bosco, P. Morel, J. P. Vallee, and T. Berney, Cell Transplant., 19, 1573 (2010).

    Article  Google Scholar 

  68. M. J. Jung, S. S. Lee, Y. H. Hwang, H. S. Jung, J.W. Hwang, M. J. Kim, S. Yoon, and D. Y. Lee, Biomaterials, 32, 9391 (2011).

    Article  CAS  Google Scholar 

  69. N. Kitamura, R. Nakai, H. Kohda, K. Furuta-Okamoto, and H. Iwata, Bioorg. Med. Chem., 21, 7175 (2013).

    Article  CAS  Google Scholar 

  70. Y. Teramura, Y. Kaneda, and H. Iwata, Biomaterials, 28, 4818 (2007).

    Article  CAS  Google Scholar 

  71. H. Nishimori, M. Kondoh, K. Isoda, S. Tsunoda, Y. Tsutsumi, and K. Yagi, Eur. J. Pharm. Biopharm., 72, 496 (2009).

    Article  CAS  Google Scholar 

  72. B. R. Jarrett, M. Frendo, J. Vogan, and A. Y. Louie, Nanotechnology, 18 (2007).

  73. B. A. Rzigalinski and J. S. Strobl, Toxicol. Appl. Pharm., 238, 280 (2009).

    Article  CAS  Google Scholar 

  74. S. J. Karlik, Am. J. Roentgenol., 188, W584 (2007).

    Article  Google Scholar 

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  1. Department of Bioengineering, College of Engineering, and BK21 PLUS Future Biopharmaceutical Human Resources Training and Research Team, and Institute of Nano Science & Technology (INST), Hanyang University, Seoul, 04763, Korea

    Min Jun Kim & Dong Yun Lee

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  1. Min Jun Kim
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Kim, M.J., Lee, D.Y. Application of nanomaterials for imaging pancreatic islets. Macromol. Res. 24, 197–204 (2016). https://doi.org/10.1007/s13233-016-4034-4

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