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Preparation and characterization of calcium phosphate cement of α-tricalcium phosphate-tetracalcium phosphate-dicalcium phosphate system incorporated with poly(γ-glutamic acid)

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Abstract

Polymeric calcium phosphate cements (PCPCs) were prepared from cement powders consisting of alphatricalcium phosphate (α-TCP), tetracalcium phosphate (TTCP) and dicalcium phosphate (DCP), and cement liquid with poly(γ-glutamic acid) (γ-PGA). The characteristics of calcium phosphate cements (CPCs), such as paste injectability, initial setting time, and compressive strength, were assessed. The injectability of PCPCs with a 0–30 wt% TTCP/DCP mixture was above 90%. The initial setting time decreased in concert with the amount of incorporated TTCP/DCP mixture and reached approximately 10–13 min when the amount of TTCP/DCP mixture was 10–30 wt%. The compressive strength of PCPC with the 30% equimolar TTCP/DCP mixture was approximately 18.4±3.5 MPa, whereas that of the CPC without the TTCP/DCP mixture was approximately 4.8±0.1 MPa.

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Authors and Affiliations

  1. Department of Nanotechnology, PaiChai University, Daejeon, 302-735, Korea

    Young Baek Kim

  2. Korea Research Institute of Chemical Technology, Daejon, 305-600, Korea

    Byung Min Lee & Sung Soo Kim

  3. Department of Orthopedic Surgery, Seoul National University Hospital, Seoul, 110-744, Korea

    Myung Chul Lee

  4. Department of Chemical and Biomacromolecular Engineering, Seoul National University of Science and Technology, Seoul, 139-743, Korea

    Insup Noh

  5. Department of Biomedical Engineering, Inje University, Gyeongnam, 621-749, Korea

    Sung-Jae Lee

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  1. Young Baek Kim
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  2. Byung Min Lee
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  3. Myung Chul Lee
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  4. Insup Noh
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  5. Sung-Jae Lee
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  6. Sung Soo Kim
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Correspondence to Sung Soo Kim.

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Kim, Y.B., Lee, B.M., Lee, M.C. et al. Preparation and characterization of calcium phosphate cement of α-tricalcium phosphate-tetracalcium phosphate-dicalcium phosphate system incorporated with poly(γ-glutamic acid). Macromol. Res. 21, 892–898 (2013). https://doi.org/10.1007/s13233-013-1109-3

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  • DOI: https://doi.org/10.1007/s13233-013-1109-3

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