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Synthesis and characterization of pH-Responsive Poly(2-hydroxyethyl aspartamide)-g-Poly(β-amino ester) graft copolymer micelles as potential drug carriers

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Abstract

Novel pH-responsive graft copolymers consisting of poly(2-hydroxyethyl aspartamide)-g-poly(β-amino ester) (PHEA-g-PAE) were prepared from polysuccinimide, which is a thermal polycondensation product of aspartic acid, via the Michael-addition reaction with β-amino ester moieties. The chemical structures of the prepared graft copolymers were characterized by 1H NMR. Their micelle properties were examined by dynamic light scattering and fluorescence spectrometry. The transmission electron microscopy images demonstrated that these micelles were regularly spherical in shape. For cancer therapy, doxorubicin (DOX) was efficiently encapsulated into the micelles. The DOX loaded micelles exhibited relatively sharp pH-dependent DOX release behavior.

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Authors and Affiliations

  1. Theranostic Macromolecules Research Center, Department of Polymer Science and Engineering, Sungkyunkwan University, Gyeonggi, 440-746, Korea

    Tao Peng, Yi Li, Dawoon Ahn, Bong Sup Kim & Doo Sung Lee

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  1. Tao Peng
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  2. Yi Li
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  3. Dawoon Ahn
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  4. Bong Sup Kim
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  5. Doo Sung Lee
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Correspondence to Doo Sung Lee.

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Peng, T., Li, Y., Ahn, D. et al. Synthesis and characterization of pH-Responsive Poly(2-hydroxyethyl aspartamide)-g-Poly(β-amino ester) graft copolymer micelles as potential drug carriers. Macromol. Res. 21, 400–405 (2013). https://doi.org/10.1007/s13233-013-1046-1

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  • DOI: https://doi.org/10.1007/s13233-013-1046-1

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