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Synthesis of stimuli-responsive PEO-based triblock copolymers and their applications for preparation of iron oxide nanoparticles

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Abstract

In this paper, the important and useful method for manufacturing superparamagnetic iron oxide nanoparticles stabilized by water-soluble poly(ethylene oxide) (PEO)-based triblock copolymers showing stimuli-responsive phase transition is introduced. Triblock copolymers, such as poly(ethylene oxide-b-N-vinylimidazole-b-3-(methacrylamino)phenylboronic acid) (PEO-b-PVIm-b-PMAPBA), poly(ethylene oxide-b-N-vinylpyrrolidone-b-3-(methacrylamino)phenylboronic acid) (PEO-b-PVP-b-PMAPBA), and poly(ethylene oxide-b-N-vinylimidazoleb-maleic acid) (PEO-b-PVIm-b-PMAc), were synthesized using the sequential monomer addition method via reversible addition fragmentation chain transfer (RAFT) radical block copolymerizations of the corresponding monomers, using PEO-based RAFT agent. After complete polymerization of N-vinylimidazole or N-vinylpyrrolidone in dimethylformamide (DMF) at 110 °C, 3-(methacrylamino)phenylboronic acid (MAPBA) was polymerized in DMF at 90 °C for 24 h, and N-phenylmaleimide was polymerized in dimethylsulfoxide (DMSO) at 110 °C for 28 h. All the block copolymers were water-soluble and efficient enough to stabilize the surface of nano-sized iron oxide particles in water. The nanoparticles were stable in neutral aqueous media for at least one month. The resulting products were characterized by a combination of 1H nuclear magnetic resonance spectroscopy (NMR), size exclusion chromatography, transmission electron microscopy (TEM), electron diffraction pattern, and phase transition behavior of the block copolymers using UV/visible spectrophotometer.

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Authors and Affiliations

  1. Department of Chemistry, Kyung Hee University, Seoul, 130-701, Korea

    Joo Hyun Nam, Woo Seok Choi, Jae Hyeok Lee, Nan Hyun Kwon, Ho-Jung Kang, Jae Yeol Lee & Jungahn Kim

  2. Biomedical Science Center, KIST, Seoul, 136-791, Korea

    Sehoon Kim

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  1. Joo Hyun Nam
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  2. Woo Seok Choi
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  3. Jae Hyeok Lee
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  4. Nan Hyun Kwon
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  6. Jae Yeol Lee
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  7. Sehoon Kim
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Correspondence to Jungahn Kim.

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Nam, J.H., Choi, W.S., Lee, J.H. et al. Synthesis of stimuli-responsive PEO-based triblock copolymers and their applications for preparation of iron oxide nanoparticles. Macromol. Res. 20, 1173–1180 (2012). https://doi.org/10.1007/s13233-012-0173-4

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  • DOI: https://doi.org/10.1007/s13233-012-0173-4

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