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Preparation of chlorine e6-conjugated single-wall carbon nanotube for photodynamic therapy

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Abstract

We fabricated single-wall carbon nanotubes (SWNTs) modified with chlorine e6 (as a photosensitizing drug: Ce6) and poly(ethylene glycol) (PEG, as a polymeric stabilizer) were fabricated to develop a light-sensitive nanovehicle for tumor treatment. The carboxyl group of Ce6 and poly(ethylene glycol) (PEG) was coupled with aminated SWNT via N,N′-dicyclohexyl carbodiimide (DCC)- and N-hydroxysuccinimide (NHS)-mediated amide formation. During light irradiation, singlet oxygen generation from Ce6 coupled to the SWNTs was reduced due to the quenching effect of SWNTs for Ce6. Unlike free Ce6, Ce6 coupled to the SWNTs accumulated to a significant degree in the tumor site, reflecting its pharmaceutical potential under in vivo conditions. This might become a potential carrier system for improving photodynamic therapy.

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Authors and Affiliations

  1. Division of Biotechnology, The Catholic University of Korea, Gyeonggi, 420-743, Korea

    Dong Jin Lee, So Young Park, Nam Muk Oh & Eun Seong Lee

  2. Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul, 120-752, Korea

    Young Taik Oh

  3. College of Pharmacy, Chung-Ang University, Seoul, 155-756, Korea

    Kyung Taek Oh

  4. College of Pharmacy, Pusan National University, Busan, 609-735, Korea

    Yu Seok Youn

  5. The Catholic Institute for Advanced Biomaterials, Gyeonggi, 420-743, Korea

    Eun Seong Lee

Authors
  1. Dong Jin Lee
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  2. So Young Park
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  3. Young Taik Oh
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  4. Nam Muk Oh
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  5. Kyung Taek Oh
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Correspondence to Eun Seong Lee.

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These authors equally contributed to this work.

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Lee, D.J., Park, S.Y., Oh, Y.T. et al. Preparation of chlorine e6-conjugated single-wall carbon nanotube for photodynamic therapy. Macromol. Res. 19, 848–852 (2011). https://doi.org/10.1007/s13233-011-0816-x

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  • DOI: https://doi.org/10.1007/s13233-011-0816-x

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