Skip to main content
SpringerLink
Log in

Self-assembly of negatively charged poly(vinyl alcohol) derivatives

  • Articles
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

This paper reports the relationship between the degree of negatively charged groups on the poly(4-vinyloxybutane sulfonate-co-vinyl alcohol) or PVA-BS and poly(4-vinyloxybutane sulfonate-co-vinyloxydodecane-covinyl alcohol) or PVA-12C-BS polymers and their self-assembled particles’ morphologies. With grafted hydrophobic moieties (PVA-12C-BS polymers), the size of the self-assembled particles decreased with increasing levels of butane sulfonate substitution. However, with no hydrophobic moiety grafted (PVA-BS), the size of the self-assembled particles increased with increasing levels of butane sulfonate substitution. The response of the PVA-BS and PVA-12C-BS polymeric particles to the loading of a model hydrophobic compound, 2-ethylhexyl-4-methoxycinnamate (EHMC), was markedly different. With the drug as a hydrophobic core, EHMC-loaded PVA-BS particles were smaller in size and more stable than the unloaded particles. In contrast, the EHMC-loaded PVA-12C-BS particles were larger than the corresponding unloaded particles.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. C. DeMerlis and D. R. Schoneker, Food Chem. Toxicol., 41, 319 (2003).

    Article  CAS  Google Scholar 

  2. C. Wang, W. Ye, Y. Zheng, X. Liu, and Z. Tong, Int. J. Pharm., 338, 165 (2007).

    Article  CAS  Google Scholar 

  3. S.-S. Feng, W. Zeng, Y. Teng Lim, L. Zhao, K. Yin Win, R. Oakley, S. H. Teoh, R. C. Hang Lee, and S. Pan, Nanomedicine-UK, 2, 333 (2007).

    Article  CAS  Google Scholar 

  4. K. Y. Win and S.-S. Feng, Biomaterials, 26, 2713 (2005).

    Article  CAS  Google Scholar 

  5. H. Takeuchi, H. Kojima, H. Yamamoto, and Y. Kawashima, J. Control. Release, 68, 195 (2000).

    Article  CAS  Google Scholar 

  6. S.-S. Feng and G. Huang, J. Control. Release, 71, 53 (2001).

    Article  CAS  Google Scholar 

  7. I. Orienti, F. Bigucci, G. Gentilomi, and V. Zecchi, J. Pharm. Sci.-US, 90, 1435 (2001).

    Article  CAS  Google Scholar 

  8. O. R. Davies, L. Head, D. Armitage, E. A. Pearson, M. C. Davies, M. Marlow, and S. Stolnik, Langmuir, 24, 7138 (2008).

    Article  CAS  Google Scholar 

  9. U. Manna and S. Patil, J. Phys. Chem. B, 113, 9137 (2009).

    Article  CAS  Google Scholar 

  10. J. K. Li, N. Wang, and X. S. Wu, J. Control. Release, 56, 117 (1998).

    Article  CAS  Google Scholar 

  11. T. Kimura, A. Okuno, K. Miyazaki, T. Furuzono, Y. Ohya, T. Ouchi, S. Mutsuo, H. Yoshizawa, Y. F. Kitamura, and A. Kishida, Mat. Sci. Eng., 24, 797 (2004).

    Article  Google Scholar 

  12. M. Madlova, S. A. Jones, I. Zwerschke, Y. Ma, R. C. Hider, and B. Forbes, Eur. J. Pharm. Biopharm., 72, 438 (2009).

    Article  CAS  Google Scholar 

  13. I. Orienti, R. Trere, and V. Zecchi, Drug Dev. Ind. Pharm., 27, 877 (2001).

    Article  CAS  Google Scholar 

  14. I. Orienti, A. Di Pietra, B. Luppi, and V. Zecchi, Arch. Pharm., 333, 421 (2000).

    Article  CAS  Google Scholar 

  15. T. Cerchiara, B. Luppi, F. Bigucci, I. Orienti, and V. Zecchi, Eur. J. Pharm. Biopharm., 56, 401 (2003).

    Article  CAS  Google Scholar 

  16. B. Luppi, I. Orienti, F. Bigucci, T. Cerchiara, G. Zuccari, S. Fazzi, and V. Zecchi, Drug Deliv., 9, 147 (2002).

    Article  CAS  Google Scholar 

  17. I. Orienti, F. Bigucci, B. Luppi, T. Cerchiara, G. Zuccari, P. Giunchedi, and V. Zecchi, Eur. J. Pharm. Biopharm., 54, 229 (2002).

    Article  CAS  Google Scholar 

  18. I. Orienti, G. Zuccari, V. Bergamante, E. Mileo, M. Lucarini, R. Carosio, and P. G. Montaldo, Biomacromolecules, 7, 3157 (2006).

    Article  CAS  Google Scholar 

  19. M. Wittmar, J. S. Ellis, F. Morell, F. Unger, J. C. Schumacher, C. J. Roberts, S. J. B. Tendler, M. C. Davies, and T. Kissel, Bioconjugate Chem., 16, 1390 (2005).

    Article  CAS  Google Scholar 

  20. M. Wittmar, F. Unger, and T. Kissel, Macromolecules, 39, 1417 (2006).

    Article  CAS  Google Scholar 

  21. G. Zuccari, R. Carosio, A. Fini, P. G. Montaldo, and I. Orienti, J. Control. Release, 103, 369 (2005).

    Article  CAS  Google Scholar 

  22. C. Luadthong, A. Tachaprutinun, and S. P. Wanichwecharungruang, Eur. Polym. J., 44, 1285 (2008).

    Article  CAS  Google Scholar 

  23. T. Jung, A. Breitenbach, and T. Kissel, J. Control. Release, 67, 157 (2000).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

    Paramee Jitjumnong & Supason P. Wanichwecharungruang

  2. National Center of Petroleum, Petrochemicals and Advanced Materials, Chulalongkorn University, Bangkok, 10330, Thailand

    Paramee Jitjumnong & Sunatda Arayachukeat

Authors
  1. Paramee Jitjumnong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Supason P. Wanichwecharungruang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sunatda Arayachukeat
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Supason P. Wanichwecharungruang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jitjumnong, P., Wanichwecharungruang, S.P. & Arayachukeat, S. Self-assembly of negatively charged poly(vinyl alcohol) derivatives. Macromol. Res. 18, 730–736 (2010). https://doi.org/10.1007/s13233-010-0816-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-010-0816-2

Keywords

Search

Navigation