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Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization

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Abstract

This article describes the preparation and characterization of hydroxypropyl methylcellulose-graft-poly(ethylacrylate-co-methyl methacrylate) particles [HPMC-g-poly(EA-co-MMA) NPs]. The particles were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN). In this study, a series of HPMC-g-poly(EA-co-MMA) NPs were synthesized by varying the CAN: HPMC and HPMC: (EA/MMA) ratios to determine the effects of these variables on the physical properties of HPMC-g-poly(EA-co-MMA) as well as the dissolution behavior of an aspirin tablet, as a model drug. The drug dissolution profiles of the coated tablets were affected significantly by the HPMC: (EA/MMA) molar ratio.

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Authors and Affiliations

  1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 120-749, Korea

    Hyon Ho Baek, Jung Min Lee, Ji Eun Cho, Jin Hun Cho & Jung Hyun Kim

  2. Department of Applied Chemistry, Kyungpook National University, Daegu, 702-701, Korea

    In Woo Cheong

Authors
  1. Hyon Ho Baek
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  2. Jung Min Lee
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  3. Ji Eun Cho
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  4. Jin Hun Cho
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  5. Jung Hyun Kim
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  6. In Woo Cheong
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Correspondence to Jung Hyun Kim or In Woo Cheong.

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Baek, H.H., Lee, J.M., Cho, J.E. et al. Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization. Macromol. Res. 18, 53–58 (2010). https://doi.org/10.1007/s13233-009-0097-9

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  • DOI: https://doi.org/10.1007/s13233-009-0097-9

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