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Carboxymethyl Polysaccharide-Based Multiunit Hydrogel Systems for Drug Delivery

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Particulate Technology for Delivery of Therapeutics

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Abstract

In recent years, natural polymers are being modified chemically to search for new materials for drug delivery applications. Natural polymers possess functional groups like hydroxyl, carboxyl, and amide that make them amenable for various modifications. Chemical modification is desirable to confer smartness to the polymers achieving pH-sensitivity, thermo-responsiveness of the delivery devices for controlled drug release. At the same time, some undesirable physicochemical properties of native polymers are elimination. The design of synthetic polymer-based particulate systems mostly involves organic solvents. However, their use in the design of drug delivery system is questionable in terms of long-term viability due to flammability, health hazards, and stringent governmental regulation. Henceforth, the scientists are involved in preparing drug-loaded particles avoiding the use of organic solvents. The gelling ability of the some native biopolymers as well as modified biopolymers with metallic salts have been utilized to fabricate particulate systems in aqueous environment. Carboxymethylation is an important reaction in offering gelling ability to the native polymers. Furthermore, the graft copolymers, hydrophobic conjugates, and interpenetrating networks have been tested in preparing drug delivery particles. This chapter discusses the carboxymethylation techniques, synthesis of particulate systems, and recent developments in drug delivery applications of some natural polymers including xanthan gum, guar gum, locust bean gum, pullulan, and curdlan.

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  1. Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol, 713301, West Bengal, India

    Sabyasachi Maiti & Sougata Jana

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  1. Sabyasachi Maiti
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  2. Sougata Jana
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Correspondence to Sabyasachi Maiti .

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  1. Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India

    Sougata Jana

  2. Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India

    Subrata Jana

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Maiti, S., Jana, S. (2017). Carboxymethyl Polysaccharide-Based Multiunit Hydrogel Systems for Drug Delivery. In: Jana, S., Jana, S. (eds) Particulate Technology for Delivery of Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-10-3647-7_7

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