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Comparison Between Sublingual and Vaginal Administration of Misoprostol in Management of Missed Abortion

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Abstract

Aim

The aim of the present study is to compare between sublingual administration of misoprostol and vaginal administration in the management of missed abortion.

Materials and Methods

The study was conducted in El-Shatby Maternity Hospital on 160 patients diagnosed as missed abortion by ultrasonographic examination. Cases were divided into two groups according to the methods of misoprostol administration, whether sublingual or vaginal. Patients of the two groups were observed for the times of uterine colic starting, cervical dilation, and conceptus expulsion, along with recording of any side effects.

Result

During the follow-up of our cases we found that sublingual route is more effective than vaginal route in the management of missed abortion. The difference between the two groups in percentage of conceptus expulsion was statistically significant. The most common side effects were nausea which was present in 55 % of cases in group I (sublingual) and in 40 % of cases in group II (vaginal) then severe pain in 25 % of cases in group I (sublingual) and in 20 % of cases in group II (vaginal) and hyperpyrexia in 15 % of cases in group I (sublingual) and in 5 % of cases in group II (vaginal).

Conclusion

Sublingual administration of misoprostol is more effective than its vaginal administration in missed abortion management. Side effect of misoprostol as nausea, vomiting, fever is more common with sublingual administration in comparison with its vaginal administration.

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Author information

Author notes

  1. Hossam Hassan Aly Hassan El Sokkary

    Present address: Obstetrics and Gynaecology Department, El Shatby University Hospital, Alexandria, Egypt

Authors and Affiliations

  1. Obstetrics and Gynaecology, Alexandria University, Alexandria, Egypt

    Hossam Hassan Aly Hassan El Sokkary

Authors
  1. Hossam Hassan Aly Hassan El Sokkary
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Corresponding author

Correspondence to Hossam Hassan Aly Hassan El Sokkary.

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Ethical approval

It meets ethical guidelines as the manuscript has been approved by ethics committee of Alexandria medical school, and a written consent has been taken from all patients about participation in research.

Additional information

Dr. Hossam Hassan Aly Hassan El Sokkary is Lecturer of Obstetrics and Gynaecology, Alexandria University, Alexandria, Egypt. He was Obstetrics and Gynaecology Residents, El Shatby Alexandria University Hospital, Alexandria, Egypt in 20 October 1996 to 19 October 1999. He was Assistant Lecturer in 4 January 2004 to 22 September 2008.

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El Sokkary, H.H.A.H. Comparison Between Sublingual and Vaginal Administration of Misoprostol in Management of Missed Abortion. J Obstet Gynecol India 66 (Suppl 1), 24–29 (2016). https://doi.org/10.1007/s13224-015-0757-y

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  • DOI: https://doi.org/10.1007/s13224-015-0757-y

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