Abstract
Objectives
To evaluate local disease control and early complications of concomitant brachytherapy with external beam-radiotherapy in early stage carcinoma cervix.
Methods
Fifty patients of early stage carcinoma cervix (FIGO-IB/IIA) were randomly divided into study group concomitant external beam irradiation (EBRT) and HDR-ICBT (intra-cavitary brachytherapy, xrt = 50 Gy/25 Fr, HDR 5.2 Gy*5 Fr) and the control group EBRT followed by HDR-ICBT (xrt = 50 Gy/25 Fr, HDR 7.5 Gy*3 Fr). Acute reactions and local disease response were compared between treatment and at 6-month follow up.
Results
Median overall treatment times were 38 and 61 days in the study and the control groups, respectively. Acute skin reactions and diarrhea were more in the study but manageable. At the completion of the study, there were 80 and 68 % complete responses, 16 and 20 % partial responses, 0 and 8 % stable diseases in the study group and the control group, respectively.
Conclusions
Response was better in the study group but statistically insignificant. Larger number of patients and longer follow up are required to arrive at concrete conclusion.
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Patidar, A.K., Kumar, H.S., Walke, R.V. et al. Evaluation of the Response of Concurrent High Dose Rate Intracavitary Brachytherapy with External Beam Radiotherapy in Management of Early Stage Carcinoma Cervix. J Obstet Gynecol India 62, 562–565 (2012). https://doi.org/10.1007/s13224-012-0209-x
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DOI: https://doi.org/10.1007/s13224-012-0209-x