Abstract
Objective
To compare amoxycillin-clavulanic acid with cefazolin as short term antibiotic prophylaxis in women undergoing hysterectomy and elective cesarean section.
Method
Sixty women undergoing hysterectomy were randomly assigned either to 2.4g intravenous amoxycillin-clavulanic acid (AMX/CL) or 2g cefazolin 30 min before hysterectomy. One hundred and twenty two women delivered by elective cesarean were randomized to a single dose of either of the above antibiotics at cord clamping. Each patient was assessed daily until discharge for evidence of febrile status and the presence of infection at the operative site and urinary tract.
Results
Infectious morbidity was found in 11% and 12.5% of hysterectomy patients in AMX/CL and cefazolin groups respectively. Ten women had post-cesarean infections (six AMXCL, four cefazolin, P=0.51)
Conclusion
Broad spectrum amoxycillin-clavulanic acid was not superior to cefazolin in the prevention of postoperative infection when given as prophylaxis in hysterectomy and elective cesarean cases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Hemsell DL. Prophylactic antibiotics in gynecologic and obstetric surgery. Rev Infect Dis 1991;13:s821–841.
Jamie W, Duff P. Preventing infections during elective C/S and abdominal hysterectomy. Contemp Obstet Gynecol 2003;48:60–69.
Smaill F, Hofmeyr GJ. Antibiotic prophylaxis for cesarean section. Cochrane Database Syst Rev 2002:CD000933.
Chelmow D. Should patients undergoing low-risk C/S receive antibiotic prophylaxis. Contemp Obstet Gynecol 2006;51:57.
Triolo O, Mancuso A, Pantano F. Amoxycillin/clavulanate prophylaxis in gynecologic surgery. Int J Gynaecol Obstet 2004;85:59–61.
Kocak I, Ustun C, Gurkan N. Prophylactic antibiotics in elective abdominal hysterectomy. Int J Gynaecol Obstet 2005;90:157–158.
Bahador A, Roy S. Prevention of postoperative gynecologic infections. In: Mishell DR, Goodwin TM, Brenner PF (Eds). Management of Common Problems in Obstetrics and Gynecology, 4th edition. Massachusetts, Blackwell Publishing, 2002:228–231.
Chelmow D, Ruehli MS, Huang E. Prophylactic use of antibiotics for nonlaboring patients undergoing cesarean delivery with intact membranes: a meta-analysis. Am J Obstet Gynecol 2001;184:656–661.
Chongsomchai C, Lumbiganon P, Thinkhamrop J et al. Placebo-controlled, double-blind, randomized study of prophylactic antibiotics in elective abdominal hysterectomy. J Hosp Infect 2002;52:302–306.
Hemsell DL, Cunningham FG, Kappus S et al. Cefoxitin for prophylaxis in premenopausal women undergoing vaginal hysterectomy. Obstet Gynecol 1980;56:629–634.
Cormio G, Di Fazio F, Cacciapuoti C et al. Prospective randomized study comparing amoxycillin-clavulanic acid with cefazolin as antimicrobial prophylaxis in laparotomic gynecologic surgery. Acta Obstet Gynecol Scand 2003;82:1130–1134.
Yip SK, Lau TK, Rogers MS. A study on prophylactic antibiotics in cesarean sections-is it worthwhile? Acta Obstet Gynecol Scand 1997;76:547–549.
Rouzi AA, Khalifa F, Ba’aqeel H et al. The routine use of cefazolin in cesarean section. Int J Gynaecol Obstet 2000;69:107–112.
Duff P. Prophylactic antibiotics for hysterectomy. Contemp Obstet Gynecol 1997;42:21–26.
Sweet RL, Gibbs RS. Antibiotic prophylaxis in obstetrics and gynecology. In: Infectious Diseases of the Female Genital Tract, 4th edition. Philadelphia, Lippincott
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jyothi, S., Vyas, N.M., Kumar, P. et al. Antibiotic prophylaxis for hysterectomy and cesarean section: Amoxicillin-clavulanic acid versus cefazolin. J Obstet Gynecol India 60, 419–423 (2010). https://doi.org/10.1007/s13224-010-0069-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13224-010-0069-1