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A comprehensive review on RNA interference-mediated targeting of interleukins and its potential therapeutic implications in colon cancer

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Abstract

Colon cancer is the world’s fourth leading cause of death. It is cancer of the latter part of the large intestine, i.e. the colon. Chronic inflammation over a long period also leads to the development of cancer. Cancer in the colon region is arduous to diagnose and is detected at a later stage when it metastasizes to other parts of the body like the liver, lungs, peritoneum, etc. Colon cancer is a great example of solid tumours associated with chronic inflammation. Although conventional therapies are effective, they lose their effectiveness beyond a certain point. Relapse of the disease occurs frequently. RNA interference (RNAi) is emerging as a great tool to specifically attack the cancer cells of a target site like the colon. RNAi deals with epigenetic changes made in the defective cells which ultimately leads to their death without harming the healthy cells. In this review, two types of epigenetic modulators have been considered, namely siRNA and miRNA, and their effect on interleukins. Interleukins, a class of cytokines, are major inflammatory responses of the body that are released by immune cells like leukocytes and macrophages. Some of these interleukins are pro-inflammatory, thereby promoting inflammation which eventually causes cancer. RNAi can prevent colon cancer by inhibiting pro-inflammatory interleukins.

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Data Availability Statement

The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of our future research study.

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Acknowledgements

The authors would like to thank SRM Institute of Science and Technology for providing us the opportunity to work on this topic.

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  1. Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603 203, India

    Sagari Sil, Janet Bertilla & S. Rupachandra

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  1. Sagari Sil
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  2. Janet Bertilla
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  3. S. Rupachandra
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Contributions

All authors contribute to the conceptualisation of the article. The literature search and the final draft of the manuscript was carried out by Sagari Sil. The outline of the review was prepared by Janet Bertilla and approved by S. Rupachandra.

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Correspondence to S. Rupachandra.

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Sil, S., Bertilla, J. & Rupachandra, S. A comprehensive review on RNA interference-mediated targeting of interleukins and its potential therapeutic implications in colon cancer. 3 Biotech 13, 18 (2023). https://doi.org/10.1007/s13205-022-03421-x

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