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Antibacterial potential of chalcones and its derivatives against Staphylococcus aureus

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Abstract

Chalcones are natural substances found in the metabolism of several botanical families. Their structure consists of 1,3-diphenyl-2-propen-1-one and they are characterized by having in their chains an α, β-unsaturated carbonyl system, two phenol rings and a three-carbon chain that unites them. In plants, Chalcones are mainly involved in the biosynthesis of flavonoids and isoflavonoids through the phenylalanine derivation. This group of substances has been shown to be a viable alternative for the investigation of its antibacterial potential, considering the numerous biological activities reported and the increase of the microbial resistance that concern global health agencies. Staphylococcus aureus is a bacterium that has stood out for its ability to adapt and develop resistance to a wide variety of drugs. This literature review aimed to highlight recent advances in the use of Chalcones and derivatives as antibacterial agents against S. aureus, focusing on research articles available on the Science Direct, Pub Med and Scopus data platforms in the period 2015–2021. It was constructed informative tables that provided an overview of which types of Chalcones are being studied more (Natural or Synthetic); its chemical name and main Synthesis Methodology. From the analysis of the data, it was observed that the compounds based on Chalcones have great potential in medicinal chemistry as antibacterial agents and that the molecular skeletons of these compounds as well as their derivatives can be easily obtained through substitutions in the A and B rings of Chalcones, in order to obtain the desired bioactivity. It was verified that Chalcones and derivatives are promising agents for combating the multidrug resistance of S. aureus to drugs.

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Fig. 1

Source: Author (2022)

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Source: Author (2022)

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Acknowledgements

The authors are thankful to the State university of Ceará—UECE; Regional University of Cariri—URCA Formatting of funding sources. Fundacąõ Cearense de Apoio ao Desenvolvimento Cientı´fico e Tecnolo´ gico—FUNCAP; Coordenacąõ de Aperfeic¸oamento de Pessoal de Nı´vel Superior—CAPES; Conselho Nacional de Desenvolvimento Cientı´fico e Tecnoloógico—CNPq.

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Authors and Affiliations

  1. Laboratory of Semi-Arid Bioprospecting (LABSEMA), Department of Biological Chemistry, URCA, Crato, CE, Brazil

    Larissa da Silva, Isydorio Alves Donato, Cicera Alane Coelho Gonçalves & Francisco Assis Bezerra da Cunha

  2. Graduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, UFPE, Recife, PE, Brazil

    Jackelyne Roberta Scherf

  3. Laboratory of Chemistry of Natural and Synthetic Product, State university of Ceará, UECE, Fortaleza, CE, Brazil

    Hélcio Silva dos Santos

  4. CECAPE, College of Dentistry, Juazeiro do Norte, CE, 63024-015, Brazil

    Edna Mori

  5. Laboratory of Microbiology and Molecular Biology (LMBM), Department of Biological Chemistry, URCA, Crato, CE, Brazil

    Henrique Douglas Melo Coutinho

Authors
  1. Larissa da Silva
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  2. Isydorio Alves Donato
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  3. Cicera Alane Coelho Gonçalves
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  4. Jackelyne Roberta Scherf
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  5. Hélcio Silva dos Santos
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  6. Edna Mori
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  7. Henrique Douglas Melo Coutinho
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  8. Francisco Assis Bezerra da Cunha
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Corresponding author

Correspondence to Henrique Douglas Melo Coutinho.

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da Silva, L., Donato, I.A., Gonçalves, C.A.C. et al. Antibacterial potential of chalcones and its derivatives against Staphylococcus aureus. 3 Biotech 13, 1 (2023). https://doi.org/10.1007/s13205-022-03398-7

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