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MiR-210-5p regulates STAT3 activation by targeting STAT5A in the differentiation of dermal fibroblasts

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Abstract

Elucidating the molecular mechanism of the microRNAs in skin fibrosis is critical for identifying a novel therapeutic strategy for hypertrophic scar (HS). In this study, it was shown that miR-210-5p is induced by TGFβ, and that overexpression of miR-210-5p promoted the differentiation of human dermal fibroblasts (HDFs) into myofibroblasts. STAT5A is required for TGFβ-induced STAT3 activity. Here, we show that miR-210-5p attenuated TGFβ-induced STAT3 signaling pathway by suppressing the expression of STAT5A. Taken together, the present study suggests that TGFβ-induced miR-210-5p reduced STAT5A expression, leading to aberrant activation of STAT3, and facilitate skin fibrosis in HDFs.

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Authors and Affiliations

  1. Nanning Damai Microneedle Hair Technology Co., Ltd. Nanning Medical Aesthetic Clinic, Nanning 530021, Guangxi, P.R. China

    Shuyi Wei

  2. Cancer Hospital Affiliated to Guangxi Medical University, Nanning 530021, Guangxi, P.R. China

    Ye Qiu

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  1. Shuyi Wei
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  2. Ye Qiu
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Correspondence to Shuyi Wei.

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Wei, S., Qiu, Y. MiR-210-5p regulates STAT3 activation by targeting STAT5A in the differentiation of dermal fibroblasts. 3 Biotech 11, 243 (2021). https://doi.org/10.1007/s13205-021-02777-w

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