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Analysis of kinetic release of dye from the temperature-sensitive poly(N-isopropylacrylamide) functionalized porous polystyrene film

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Abstract

We have analyzed the temperature-sensitive kinetic release of dye from a temperature-sensitive porous polymer film in which poly(N-isopropylacrylamide) (PNIPAAm) was functionalized. For the temperature-sensitive kinetic release, rhodamine 6G (RhG) was used as a substitute for a drug molecule. The releasing experiment was done by using a flow UV–Vis spectrophotometer. To support the temperature-sensitive kinetic release of RhG, temperature-dependent morphology of the porous film was studied by the scanning electron microscopy (SEM) and was compared to the temperature below and above the lower critical solution temperature (LCST) (~ 32.5 °C) of the PNIPAAm. The SEM images showed a higher rugged surface morphology of the porous PNIPAAm film with the increase in temperature above the LCST. An exponential increase in the RhG release was observed at 32–34 ºC, which is higher than the LCST of PNIPAAm. This means that the change of the pore surface from the coil to the globule state supports the temperature-sensitive release by the de-swelling of PNIPAAm in addition to the release by diffusion. The RhG release over time at different temperatures was also theoretically analyzed using the Korsmeyer–Peppas kinetic model.

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Funding

This research was funded by the National Research Foundation of Korea (Grant No. 2021-R1F1A1052602).

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Authors and Affiliations

  1. Department of Chemistry and Nano Science and Engineering, Center for Nano Manufacturing, Inje University, Gyeongsangnam-do, Gimhae, South Korea

    Shahkar Falak, Bo Kyoung Shin & Do Sung Huh

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  1. Shahkar Falak
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  2. Bo Kyoung Shin
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  3. Do Sung Huh
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Contributions

All the authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by SF, BKS and DSH. The first draft of the manuscript was written by SF and DSH and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript.

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Correspondence to Do Sung Huh.

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The authors certify that this work is not under consideration for publication elsewhere in any medium, including electronic journals, computer databases, and publicly accessible preprint websites and is approved for publication by all the co-authors and the responsible authorities, and also declare no conflict of interest regarding the financial interests.

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Falak, S., Shin, B.K. & Huh, D.S. Analysis of kinetic release of dye from the temperature-sensitive poly(N-isopropylacrylamide) functionalized porous polystyrene film. Appl Nanosci 12, 3229–3236 (2022). https://doi.org/10.1007/s13204-022-02690-5

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  • DOI: https://doi.org/10.1007/s13204-022-02690-5

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