Skip to main content

Advertisement

SpringerLink
Log in

Evaluations of biosynthesized Ag nanoparticles via Allium Sativum flower extract in biological applications

  • Original Article
  • Published:
Applied Nanoscience Aims and scope Submit manuscript

Abstract

The eco-friendly phytomediated synthesis of Ag nanoparticles provides better efficient applications than synthetic methods. Ag nanoparticles are considered by researchers due to its specific properties. The phytochemical analysis of Allium Sativum flower extract provides the phytochemicals exist in it. Due to this, the efficient eco-friendly synthesis of Ag nanoparticles via Allium Sativum flower extract has performed. The X-ray diffraction pattern exposes the crystalline nature with the mean crystallite size at 25 nm. The Fourier Transform Infra-Red spectrum displays the phytochemicals involved in the synthesis. The UV–Visible spectrum illustrates the formation of Ag nanoparticles with SPR band at 436 nm. The particle size analyzer demonstrates the size of formed Ag particles in 20–35 nm. The morphological, elemental and structural analyzes demonstrate the formation of spherical shaped Ag nanoparticles. The formation of Ag nanoparticles was confirmed by the appearance of Ag peak in Energy Dispersive X-ray Diffraction spectrum and mapping study. The antimicrobial activity explains the effective antimicrobial effect on human pathogens. The antioxidant activity reports the efficient scavenging property of synthesized Ag nanoparticles. The anti-inflammatory activity reveals the potential ability of protein denaturation on bovine serum albumin. The anti-diabetic activity exhibits much inhibition on α-Amylase. The anticancer activity reports the effective inhibition of synthesized Ag nanoparticles on human MCF-7 breast cancer cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15

Similar content being viewed by others

References

  • Ahmed S, Ullah S, Ahmad M, Swami BL, Ikram S (2016) Green synthesis of silver nanoparticles using Azadirachta indica aqueous leaf extract. J Radiat Res Appl Sci 9(1):1–7

    Google Scholar 

  • Al-Asfar A, Zaheer Z, Aazam ES (2018) Eco-friendly green synthesis of Ag@Fe bimetallic nanoparticles: antioxidant, antimicrobial and photocatalytic degradation of bromothymol blue. J Photochem Photobiol B 185:143–152

    CAS  Google Scholar 

  • Anand K, Tiloke C, Naidoo P, Chuturgoon AA (2017) Phytonanotherapy for management of diabetes using green synthesis nanoparticles. J Photochem Photobiol B 173:626–639

    CAS  Google Scholar 

  • Anandalakshmi K, Venugobal J, Ramasamy V (2016) Characterization of silver nanoparticles by green synthesis method using Pedalium murex leaf extract and their antibacterial activity. Appl Nanosci 6(3):399–408

    CAS  Google Scholar 

  • Awwad AM, Salem NM (2012) Green synthesis of silver nanoparticles by mulberry leaves extract. J Nanosci Nanotechno 2(4):125–128

    CAS  Google Scholar 

  • Awwad AM, Salem NM, Abdeen AO (2013) Green synthesis of silver nanoparticles using carob leaf extract and its antibacterial activity. Int J Ind Chem 4(1):29

    Google Scholar 

  • Banerjee P, Satapathy M, Mukhopahayay A, Das P (2014) Leaf extract mediated green synthesis of silver nanoparticles from widely available Indian plants: synthesis, characterization, antimicrobial property and toxicity analysis. Bioresource Bioprocess 1(1):3

    Google Scholar 

  • Bar H, Bhui DK, Sahoo GP, Sarkar P, De SP, Misra A (2009) Green synthesis of silver nanoparticles using latex of Jatropha curcas. Colloid Surfaces A 339(1–3):134–139

    CAS  Google Scholar 

  • Borek C (1015S) Antioxidant health effects of aged garlic extract. J Nutrit 131(3):1010S–1015S

    CAS  Google Scholar 

  • Chandra S, Chatterjee P, Dey P, Bhattacharya S (2012) Evaluation of in vitro anti-inflammatory activity of coffee against the denaturation of protein. Asian Pac J Trop Biomed 2(1):S178–S180

    Google Scholar 

  • Chen S, Zhang S, Galluzzi M, Li F, Zhang X, Yang X, Liu X, Cai X, Zhu X, Du B, Li J, Huang P (2019a) Insight into multifunctional polyester fabrics finished by one-step eco-friendly strategy. Chem Eng J 358:634–642

    CAS  Google Scholar 

  • Chen X, Chen Y, Zou L, Zhang X, Dong Y, Tang J, Julian McClements D, Liu W (2019b) Plant-Based Nanoparticles Prepared from Proteins and Phospholipids Consisting of a Core-Multilayer-Shell Structure: Fabrication, Stability, and Foamability. J Agric Food Chem 67(23):6574–6584

    CAS  Google Scholar 

  • Danaei M, Dehghankhold M, Ataei S, Hasanzadeh Davarani F, Javanmard R, Dokhani A, Mozafari MR (2018) Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics 10(2):57

    Google Scholar 

  • David L, Moldovan B, Vulcu A, Olenic L, Perde-Schrepler M, Fischer-Fodor E, Filip GA (2014) Green synthesis, characterization and anti-inflammatory activity of silver nanoparticles using European black elderberry fruits extract. Colloids Surf B 122:767–777

    CAS  Google Scholar 

  • Dhand V, Soumya L, Bharadwaj S, Chakra S, Bhatt D, Sreedhar B (2016) Green synthesis of silver nanoparticles using Coffea arabica seed extract and its antibacterial activity. Mater Sci Eng C 58:36–43

    CAS  Google Scholar 

  • Dipankar C, Murugan S (2012) The green synthesis, characterization and evaluation of the biological activities of silver nanoparticles synthesized from Iresine herbstii leaf aqueous extracts. Colloids Surf B 98:112–119

    CAS  Google Scholar 

  • Gharibshahi L, Saion E, Gharibshahi E, Shaari AH, Matori KA (2017) Structural and optical properties of Ag nanoparticles synthesized by thermal treatment method. Mater 10(4):402

    Google Scholar 

  • Hamelian M, Zangeneh MM, Amisama A, Varmira K, Veisi H (2018) Green synthesis of silver nanoparticles using Thymus kotschyanus extract and evaluation of their antioxidant, antibacterial and cytotoxic effects. Appl Organomet Chem 32(9):e4458

    Google Scholar 

  • Han F, Lv S, Li Z, Jin L, Fan B, Zhang J, Zhang R, Zhang X, Han L, Li J (2020) Triple-synergistic 2D material-based dual-delivery antibiotic platform. NPG Asia Mater 12(15):1–11

    Google Scholar 

  • Hariharan D, Thangamuniyandi P, Christy AJ, Vasantharaja R, Selvakumar P, Sagadevan S, Nehru LC (2020) Enhanced photocatalysis and anticancer activity of green hydrothermal synthesized Ag@ TiO2 nanoparticles. J Photochem Photobiol B 202:111636

    CAS  Google Scholar 

  • Ishwarya R, Vaseeharan B, Kalyani S, Banumathi B, Govindarajan M, Alharbi NS, Benelli G (2018) Facile green synthesis of zinc oxide nanoparticles using Ulva lactuca seaweed extract and evaluation of their photocatalytic, antibiofilm and insecticidal activity. J Photochem Photobiol B 178:249–258

    CAS  Google Scholar 

  • Jagtap UB, Bapat VA (2013) Green synthesis of silver nanoparticles using Artocarpus heterophyllus Lam. seed extract and its antibacterial activity. Ind Crops Prod 46:132–137

    CAS  Google Scholar 

  • Jayaprakash N, Vijaya JJ, Kaviyarasu K, Kombaiah K, Kennedy LJ, Ramalingam RJ, Al-Lohedan HA (2017) Green synthesis of Ag nanoparticles using Tamarind fruit extract for the antibacterial studies. J Photochem Photobiol B 169:178–185

    CAS  Google Scholar 

  • Jin L, Li J, Liu L, Wang Z, Zhang X (2018) Facile synthesis of carbon dots with superior sensing ability. Appl Nanosci 8(5):1189–1196

    CAS  Google Scholar 

  • Kahrilas GA, Wally LM, Fredrick SJ, Hiskey M, Prieto AL, Owens JE (2014) Microwave-assisted green synthesis of silver nanoparticles using orange peel extract. ACS Sustain Chem Eng 2(3):367–376

    CAS  Google Scholar 

  • Kajani AA, Bordbar AK, Esfahani SHZ, Khosropour AR, Razmjou A (2014) Green synthesis of anisotropic silver nanoparticles with potent anticancer activity using Taxus baccata extract. RSC Adv 4(106):61394–61403

    CAS  Google Scholar 

  • Khalil MM, Ismail EH, El-Baghdady KZ, Mohamed D (2014) Green synthesis of silver nanoparticles using olive leaf extract and its antibacterial activity. Arab J Chem 7(6):1131–1139

    CAS  Google Scholar 

  • Khatua A, Prasad A, Priyadarshini E, Patel AK, Naik A, Saravanan M, Meena R (2019) Emerging antineoplastic plant-based gold nanoparticle synthesis: a mechanistic exploration of their anticancer activity toward cervical cancer cells. J Clust Sci 30:1–12

    Google Scholar 

  • Kumar PV, Pammi SV, Kollu P, Satyanarayana KV, Shameem U (2014a) Green synthesis and characterization of silver nanoparticles using Boerhaavia diffusa plant extract and their anti bacterial activity. Ind Crops Prod 52:562–566

    Google Scholar 

  • Kumar DA, Palanichamy V, Roopan SM (2014b) Green synthesis of silver nanoparticles using Alternanthera dentata leaf extract at room temperature and their antimicrobial activity. Spectrochim Acta A 127:168–171

    CAS  Google Scholar 

  • Lebedev A, Anariba F, Tan JC, Li X, Wu P (2018) A review of physiochemical and photocatalytic properties of metal oxides against Escherichia coli. J Photochem Photobiol A 360:306–315

    CAS  Google Scholar 

  • Li S, Shen Y, Xie A, Yu X, Qiu L, Zhang L, Zhang Q (2007) Green synthesis of silver nanoparticles using Capsicum annuum L extract. Green Chem 9(8):852–858

    CAS  Google Scholar 

  • Li Y, Dong Y, Yang Y, Yu P, Zhang Y, Hu J, Li T, Zhang X, Liu X, Xu Q, Huang Q, Lin C (2018a) Rational design of silver gradient for studying size effect of silver nanoparticles on contact killing. ACS Biomater Sci Eng 5(2):425–431

    Google Scholar 

  • Li Z, Le W, Cui Z (2018b) A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion. Cell Death Discov 4(1):1–10

    Google Scholar 

  • Lingaraju K, Naika HR, Nagabhushana H, Nagaraju G (2019) Euphorbia heterophylla (L.) mediated fabrication of ZnO NPs: characterization and evaluation of antibacterial and anticancer properties. Biocatal Agri Biotechnol 18:100894

    Google Scholar 

  • Manikandan R, Manikandan B, Raman T, Arunagirinathan K, Prabhu NM, Babu MJ, Perumal M, Palanisamy S, Munusamy A (2015) Biosynthesis of silver nanoparticles using ethanolic petals extract of Rosa indica and characterization of its antibacterial, anticancer and anti-inflammatory activities. Spectrochim Acta A 138:120–129

    CAS  Google Scholar 

  • Muthulakshmi V, Balaji M, Sundrarajan M (2019) Ionic liquid mediated morphologically improved lanthanum oxide nanoparticles by Andrographis paniculata leaves extract and its biomedical applications. J Rare Earths 38:281–291

    Article  Google Scholar 

  • Pandurangan M, Enkhtaivan G, Kim DH (2016) Anticancer studies of synthesized ZnO nanoparticles against human cervical carcinoma cells. J Photochem Photobiol B 158:206–211

    CAS  Google Scholar 

  • Parekh G, Shi Y, Zheng J, Zhang X, Leporatti S (2018) Nano-carriers for targeted delivery and biomedical imaging enhancement. Ther Deliv 9(6):451–468

    CAS  Google Scholar 

  • Philip D (2009) Biosynthesis of Au, Ag and Au–Ag nanoparticles using edible mushroom extract. Spectrochim Acta A 73(2):374–381

    Google Scholar 

  • Philip D (2010) Green synthesis of gold and silver nanoparticles using Hibiscus rosa sinensis. Physica E Low Dimens Syst Nanostruct 42(5):417–1424

    Google Scholar 

  • Philip D, Unni C, Aromal SA, Vidhu VK (2011) Murraya koenigii leaf-assisted rapid green synthesis of silver and gold nanoparticles. Spectrochim Acta A 78(2):899–904

    Google Scholar 

  • Prakash P, Gnanaprakasam P, Emmanuel R, Arokiyaraj S, Saravanan M (2013) Green synthesis of silver nanoparticles from leaf extract of Mimusops elengi, Linn. for enhanced antibacterial activity against multi drug resistant clinical isolates. Colloids Surf B 108:255–259

    CAS  Google Scholar 

  • Rahimi-Esboei B, Ebrahimzadeh MA, Fathi H, Rezaei Anzahaei F (2016) Scolicidal effect of Allium sativum flowers on hydatid cyst protoscolices. Eur Rev Med Pharmacol Sci 20(1):129–132

    CAS  Google Scholar 

  • Ravichandran V, Vasanthi S, Shalini S, Shah SAA, Harish R (2016) Green synthesis of silver nanoparticles using Atrocarpus altilis leaf extract and the study of their antimicrobial and antioxidant activity. Mater Lett 180:264–267

    CAS  Google Scholar 

  • Rodríguez-Luis OE, Hernandez-Delgadillo R, Sánchez-Nájera RI, Martínez-Castañón GA, Niño-Martínez N, Sánchez Navarro MDC, Cabral-Romero C (2016) Green synthesis of silver nanoparticles and their bactericidal and antimycotic activities against oral microbes. J Nanomater 2016:9204573

    Google Scholar 

  • Shameli K, Ahmad MB, Zamanian A, Sangpour P, Shabanzadeh P, Abdollahi Y, Zargar M (2012) Green biosynthesis of silver nanoparticles using Curcuma longa tuber powder. Int J Nanomed 7:5603

    CAS  Google Scholar 

  • Shankar SS, Ahmad A, Sastry M (2003) Geranium leaf assisted biosynthesis of silver nanoparticles. Biotechnol Prog 19(6):1627–1631

    CAS  Google Scholar 

  • Sharma VK, Yngard RA, Lin Y (2009) Silver nanoparticles: green synthesis and their antimicrobial activities. Adv Colloid Interface Sci 145(1–2):83–96

    CAS  Google Scholar 

  • Shimada K, Fujikawa K, Yahara K, Nakamura T (1992) Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. J Agr Food Chem 40(6):945–948

    CAS  Google Scholar 

  • Sofowara AE (1993) Medicinal plants and traditional medicine in Africa, 2nd edn. Spectrum books Ltd., Ibadan, Nigeria

    Google Scholar 

  • Sulaiman GM, Mohammed WH, Marzoog TR, Al-Amiery AAA, Kadhum AAH, Mohamad AB (2013) Green synthesis, antimicrobial and cytotoxic effects of silver nanoparticles using Eucalyptus chapmaniana leaves extract. Asian Pac J Trop Biomed 3(1):58–63

    CAS  Google Scholar 

  • Tang P, Shen DY, Xu YQ, Zhang XC, Shi J, Yin JF (2018) Effect of fermentation conditions and plucking standards of tea leaves on the chemical components and sensory quality of fermented juice. J Chem 2018:4312875

    Article  Google Scholar 

  • Velsankar K, Sudhahar S, Maheshwaran G (2019) Effect of biosynthesis of ZnO nanoparticles via Cucurbita seed extract on Culex tritaeniorhynchus mosquito larvae with its biological applications. J Photochem Photobiol B 200:111650

    Google Scholar 

  • Velsankar K, Sudhahar S, Parvathy G, Kaliammal R (2020) Effect of cytotoxicity and antibacterial activity of biosynthesis of ZnO hexagonal shaped nanoparticles by Echinochloa frumentacea grains extract as a reducing agent. Mater Chem Phys 239:121976

    CAS  Google Scholar 

  • Venugopal K, Rather HA, Rajagopal K, Shanthi MP, Sheriff K, Illiyas M, Maaza M (2017) Synthesis of silver nanoparticles (Ag NPs) for anticancer activities (MCF 7 breast and A549 lung cell lines) of the crude extract of Syzygium aromaticum. J Photochem Photobiol B 167:282–289

    CAS  Google Scholar 

  • Vergaro V, Scarlino F, Bellomo C, Rinaldi R, Vergara D, Maffia M, Baldassarre F, Giannelli G, Zhang X, Lvov YM, Leporatti S (2011) Drug-loaded polyelectrolyte microcapsules for sustained targeting of cancer cells. Adv Drug Deliv Rev 63(9):847–864

    CAS  Google Scholar 

  • Xue Y, Yu G, Shan Z, Li Z (2018) Phyto-mediated synthesized multifunctional Zn/CuO NPs hybrid nanoparticles for enhanced activity for kidney cancer therapy: a complete physical and biological analysis. J Photochem Photobiol B 186:131–136

    CAS  Google Scholar 

  • Yang Y, Jin P, Zhang X, Ravichandran N, Ying H, Yu C, Ying H, Xu Y, Yin J, Wang K, Wu M, Du Q (2017) New epigallocatechin gallate (EGCG) nanocomplexes co-assembled with 3-mercapto-1-hexanol and β-lactoglobulin for improvement of antitumor activity. J Biomed Nanotech 13(7):805–814

    CAS  Google Scholar 

  • Yousefi A, Yousefi R, Panahi F, Sarikhani S, Zolghadr AR, Bahaoddini A, Khalafi-Nezhad A (2015) Novel curcumin-based pyrano [2, 3-d] pyrimidine anti-oxidant inhibitors for α-amylase and α-glucosidase: Implications for their pleiotropic effects against diabetes complications. Int J Biol Macromol 78:46–55

    CAS  Google Scholar 

  • Zayed MF, Eisa WH, Shabaka AA (2012) Malva parviflora extract assisted green synthesis of silver nanoparticles. Spectrochim Acta A 98:423–428

    CAS  Google Scholar 

  • Zhang X (2015) Tea and cancer prevention. J Cancer Res Updates 4(2):65–73

    CAS  Google Scholar 

  • Zhang X, Parekh G, Guo B, Huang X, Dong Y, Han W, Chen X, Xiao G (2019) Polyphenol and self-assemble: metal polyphenol nanonetwork for drug delivery and pharmaceutical applications. Future Drug Discov. https://doi.org/10.4155/fdd-2019-0001

    Article  Google Scholar 

  • Zhou M, Zhang X, Xie J, Qi R, Lu H, Leporatti S, Chen J, Hu Y (2018) pH-Sensitive Poly(β-amino ester)s nanocarriers facilitate the inhibition of drug resistance in breast cancer cells. Nanomaterials 8(11):952

    Google Scholar 

Download references

Acknowledgements

Authors acknowledge the scheme MHRD-RUSA PHASE-2.0 (grant sanctioned vide Letter No.F.24–51/2014-U, Policy (TNMulti-Gen), Dept.of Edn. Govt. of India, Dt.09.10.2018) New Delhi and DST-PURSE-II New Delhi for a grant. Also, the authors express their thanks to UGC-SAP, DST-FIST and Alagappa University, Karaikudi-03, Tamil Nadu, India for their encouragement and providing excellent facilities.

Author information

Authors and Affiliations

  1. Department of Physics, Alagappa University, Karaikudi, 630003, India

    K. Velsankar, R. Preethi & S. Sudhahar

  2. Department of Biotechnology, Alagappa University, Karaikudi, 630003, India

    P.S. Jeevan Ram & M. Ramesh

Authors
  1. K. Velsankar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Preethi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P.S. Jeevan Ram
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Ramesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Sudhahar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Sudhahar.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Velsankar, K., Preethi, R., Ram, P.J. et al. Evaluations of biosynthesized Ag nanoparticles via Allium Sativum flower extract in biological applications. Appl Nanosci 10, 3675–3691 (2020). https://doi.org/10.1007/s13204-020-01463-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13204-020-01463-2

Keywords

Search

Navigation