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Development of biofabricated gold nanoparticles for the treatment of alleviated arthritis pain

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Abstract

In this paper, we showed the gold nanoparticles (Au NPs) synthesis using the aqueous leaf extract of Mansoa alliacea. The biofabricated Au NPs were studied using X-ray diffractometer (XRD), UV–Vis spectroscopy, transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy, and energy dispersive X-ray analysis. XRD results confirmed the crystalline nature of Au NPs with face centered cubic structure. TEM images confirmed that the particles are in the range of 20–30 nm. Further, the prepared Au NPs effects were determined by the tail-flick examination, a sensitive drugs model which acts at central nervous system. The thermal threshold’s maximum increase was noticed to be 3.6 times to that of vehicle treated at 2 h after treatments. Au NPs were even capable to inverse the complete Freund’s adjuvant induced thermal hyperalgesia, which is same as detected under physiological situations.

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Authors and Affiliations

  1. Department of Rehabilitation, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, 450052, China

    Hengyuan An, Zhiming Song, Peng Li, Gang Wang & Bingquan Ma

  2. Department of Pain Management, The First Affiliated Hospital, Jinan University, NO.613 , Whampoa Avenue, Guangzhou, 510630, China

    Xiaoping Wang

Authors
  1. Hengyuan An
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  2. Zhiming Song
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  3. Peng Li
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  4. Gang Wang
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  5. Bingquan Ma
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  6. Xiaoping Wang
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Corresponding authors

Correspondence to Bingquan Ma or Xiaoping Wang.

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An, H., Song, Z., Li, P. et al. Development of biofabricated gold nanoparticles for the treatment of alleviated arthritis pain. Appl Nanosci 10, 617–622 (2020). https://doi.org/10.1007/s13204-019-01135-w

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  • DOI: https://doi.org/10.1007/s13204-019-01135-w

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