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Bimetallic redox nanoprobe enhances the therapeutic efficacy of hyperthermia in drug-resistant cancer cells

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Abstract

Cancer nanotheranostics has emerged as one of the most promising fields of medicine wherein nano-sized molecules/agents are used for combined diagnosis and treatment of cancer. Despite promises of novel cancer therapeutic approaches, several crucial challenges have remained to be overcome for successful clinical translation of such agents. Hence, the present study has been aimed to investigate the therapeutic efficacy of bimetallic gadolinium super-paramagnetic iron oxide nanoformulation of ascorbic acid in synergism with hyperthermia on ascorbic acid-resistant breast cancer cells. This particular strategy provides real-time MRI-based non-invasive imaging of drug loading in resistant cancer cells along with highly enhanced therapeutic efficacy. This unique redox nanoprobe is capable of reversing drug-resistance mechanism in cancer cells and offers better therapeutic possibilities in targeted and effective destruction of drug-resistant cancer cells.

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Acknowledgements

The authors thank the Department of Radiology, Princess Esra Hospital, Hyderabad, for providing facility to conduct MRI contrast imaging.

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Authors and Affiliations

  1. Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, Telangana, 500058, India

    Sandeep Kumar Vishwakarma, Chandrakala Lakkireddy, Tuba Marjan, Anjum Fatima, Avinash Bardia, Syed Ameer Basha Paspala, Md. Aejaz Habeeb & Aleem Ahmed Khan

  2. Dr. Habeebullah Life Sciences, Attapur, Hyderabad, Telangana, India

    Sandeep Kumar Vishwakarma, Chandrakala Lakkireddy, Tuba Marjan, Anjum Fatima, Avinash Bardia, Syed Ameer Basha Paspala, Md. Aejaz Habeeb & Aleem Ahmed Khan

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  1. Sandeep Kumar Vishwakarma
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  2. Chandrakala Lakkireddy
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  3. Tuba Marjan
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  4. Anjum Fatima
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  5. Avinash Bardia
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  6. Syed Ameer Basha Paspala
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  7. Md. Aejaz Habeeb
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  8. Aleem Ahmed Khan
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Correspondence to Aleem Ahmed Khan.

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Vishwakarma, S.K., Lakkireddy, C., Marjan, T. et al. Bimetallic redox nanoprobe enhances the therapeutic efficacy of hyperthermia in drug-resistant cancer cells. Appl Nanosci 8, 1493–1504 (2018). https://doi.org/10.1007/s13204-018-0814-9

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  • DOI: https://doi.org/10.1007/s13204-018-0814-9

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