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Fortifying jelly foods with microencapsulated anti-anaemic compounds, ferrous gluconate, ascorbic acid and folic acid

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Abstract

Low ferrous iron bioavailability presents a challenge for food fortification programmes. In this study, jelly foods were fortified with spray-dried chitosan microparticles that had been loaded with ferrous gluconate (FeG) and folic acid (FA) to alleviate iron deficiency anaemia and FA deficiency anaemia, respectively. The presence of FA and ascorbic acid (AA) increased the in vitro iron bioavailability of the FeG-AA-FA microparticles up to sixfold. Furthermore, the iron bioavailability of the fortified jelly foods increased more than 5 folds compared to that of the FeG–AA–FA microparticles. The use of lower temperature during the preparation of fortified jelly foods is recommended to avoid the microparticles’ decomposition and a Maillard browning reaction. These findings can help food technologists and product developers select formulations with higher ferrous bioavailability to reduce the prevalence of anaemia.

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All data generated or analysed during this study are included in this published article and its supplementary information files.

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Abbreviations

FeG:

Ferrous gluconate

FA:

Folic acid

AA:

Ascorbic acid

M:

FeG, AA, and FA-loaded chitosan microparticles

G:

Unfortified jelly foods

GM:

Fortified jelly foods

References

  • Akhtar S, Anjum FM, Anjum MA (2011) Micronutrient fortification of wheat flour: recent development and strategies. Food Res Int 44:652–659

    Article  CAS  Google Scholar 

  • AOAC (2005) Official methods of analysis, 18th edn. Association of Official Analytical Chemists, Arlington

    Google Scholar 

  • Barragán-ibañeZ G, Santoyo-sánchez A, Ramos-Peñafiel C (2016) Iron deficiency anaemia. Revista Méd Del Hospital General De México 79:88–97

    Article  Google Scholar 

  • Blanco-rojo R, Vaquero M (2018) Iron bioavailability from food fortification to precision nutrition. A review. Innov Food Sci Emerging Technol 51:126–138

    Article  Google Scholar 

  • Desai K, Park H (2005) Encapsulation of vitamin C in tripolyphosphate cross-linked chitosan microspheres by spray drying. J Microencapsul 22:179–192

    Article  CAS  Google Scholar 

  • Deutsch JC (2000) Dehydroascorbic acid. J Chromatogr A 881:299–307

    Article  CAS  Google Scholar 

  • Gupta C, Chawla P, Arora S, Tomar S, Singh A (2015) Iron microencapsulation with blend of gum arabic, maltodextrin and modified starch using modified solvent evaporation method–milk fortification. Food Hydrocolloids 43:622–628

    Article  CAS  Google Scholar 

  • Gutiérrez G, Matos M, Barrero P, Pando D, Iglesias O, Pazos C (2016) Iron-entrapped niosomes and their potential application for yogurt fortification. LWT-Food Sci Technol 74:550–556

    Article  Google Scholar 

  • Habeych E, Van Kogelenberg V, Sagalowicz L, Michel M, Galaffu N (2016) Strategies to limit colour changes when fortifying food products with iron. Food Res Int 88:122–128

    Article  CAS  Google Scholar 

  • Handayani NA, Krisanti EA, Kartohardjono S, Mulia K (2020) Cyclic voltammetry and oxidation rate studies of ferrous gluconate complex solutions for preparation of chitosan-tripolyphosphate microparticles. J Chem 2092:1–8

    Article  Google Scholar 

  • Jiang W-Z, Cai Y, Li H-Y (2017) Chitosan-based spray-dried mucoadhesive microspheres for sustained oromucosal drug delivery. Powder Technol 312:124–132

    Article  CAS  Google Scholar 

  • Krisanti EA, Naziha GM, Amany NS, Mulia K, Handayani NA (2019) Effect of biopolymers composition on release profile of iron (II) fumarate from chitosan-alginate microparticles. IOP Conf Ser: Mater. Sci. Eng 509:012100

    Article  CAS  Google Scholar 

  • Kulig D, Zimoch-Korzycka A, Jarmoluk A, Marycz K (2016) Study on alginate–chitosan complex formed with different polymers ratio. Polymers 8:167

    Article  Google Scholar 

  • Kumar S, Anukiruthika T, Dutta S, Kashyap A, Moses JA, Anandharamakrishnan C (2020) Iron deficiency anemia: A comprehensive review on iron absorption, bioavailability and emerging food fortification approaches. Trends Food Sci Technol 99:58–75

    Article  Google Scholar 

  • Liu W, Wu WD, Selomulya C, Chen XD (2011) Uniform chitosan microparticles prepared by a novel spray-drying technique. Int J Chem Engi 26:1–7

    Google Scholar 

  • Morita T (2003) Development of deglutition aid jelly for oral administration. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan 123:665–671

    Article  CAS  Google Scholar 

  • Mulia K, Putri T, Krisanti EA, Handayani NA (2019) Preparation and evaluation of chitosan biopolymers encapsulated iron gluconate using spray drying method. AIP Conf Proc 2054:030005

    Article  Google Scholar 

  • Otálora MC, de Jesús Barbosa H, Perilla JE, Osorio C, Nazareno MA (2019) Encapsulated betalains (Opuntia ficus-indica) as natural colorants. Case Study: Gummy Candies LWT 103:222–227

    Google Scholar 

  • Oy S, Witjaksono F, Mustafa A, Setyobudi SI, Fahmida U (2019) Problem nutrients in adolescent girls with anemia versus nonanemic adolescent girls and the optimized food-based recommendations to meet adequacy of these nutrients in adolescent school girls in East Java, Indonesia. Food Nutr Bull 40:295–307

    Article  Google Scholar 

  • Pérez-masiá R, López-nicolás R, Periago MJ, Ros G, Lagaron JM, López-rubio A (2015) Encapsulation of folic acid in food hydrocolloids through nanospray drying and electrospraying for nutraceutical applications. Food Chem 168:124–133

    Article  Google Scholar 

  • Singh P, Prasad S (2018) Determination of ascorbic acid and its influence on the bioavailability of iron, zinc and calcium in Fijian food samples. Microchem J 139:119–124

    Article  CAS  Google Scholar 

  • Toohey JI (2008) Dehydroascorbic acid as an anti-cancer agent. Cancer Lett 263:164–169

    Article  CAS  Google Scholar 

  • Tripathi B, Platel K (2011) Iron fortification of finger millet (Eleucine coracana) flour with EDTA and folic acid as co-fortificants. Food Chem 126:537–542

    Article  CAS  Google Scholar 

  • Umemura K, Kawai S (2007) Modification of chitosan by the Maillard reaction using cellulose model compounds. Carbohyd Polym 68:242–248

    Article  CAS  Google Scholar 

  • Voron’ko NG, Derkach SR, Kuchina YA, Sokolan NI (2016) The chitosan–gelatin (bio) polyelectrolyte complexes formation in an acidic medium. Carbohydrate Polym 138:265–272

    Article  Google Scholar 

  • Webber V, De Siqueira Ferreira D, Barreto PLM, Weiss-Angeli V, Vanderlinde R (2018) Preparation and characterization of microparticles of β-cyclodextrin/glutathione and chitosan/glutathione obtained by spray-drying. Food Res Int 105:432–439

    Article  CAS  Google Scholar 

  • Zhong C, Tan S, Langrish T (2019) Redness generation via Maillard reactions of whey protein isolate (WPI) and ascorbic acid (vitamin C) in spray-dried powders. J Food Eng 244:11–20

    Article  CAS  Google Scholar 

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Acknowledgements

The authors would like to thank Dr. Umi Fahmida for her valuable comments and suggestions for this article.

Funding

This study was financially supported by Ministry of Research and Technology/National Agency for Research and Innovation through PDD Research Scheme contract number 1852/PKS/R/UI/2019.

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Authors

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Conceptualization (NAH, KM, SK, EAK); methodology (NAH); validation (NAH, KM, SK, EAK); formal analysis (NAH); investigation (NAH); resources (KM, SK, EAK); data curation (NAH); writing—original draft preparation (NAH); writing—review and editing (NAH, KM, SK, EAK); visualization (NAH); supervision (KM, SK, EAK); funding acquisition (SK).

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Correspondence to Sutrasno Kartohardjono or Elsa Anisa Krisanti.

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Handayani, N.A., Mulia, K., Kartohardjono, S. et al. Fortifying jelly foods with microencapsulated anti-anaemic compounds, ferrous gluconate, ascorbic acid and folic acid. J Food Sci Technol 60, 147–159 (2023). https://doi.org/10.1007/s13197-022-05599-7

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