Abstract
Four Sri Lankan porridges including madathawalu (MWP), kaluheenati (KHP), mixed rice of sudu heenati, goda heenati, masuran, and dikwee (MXP) and special traditional porridge (STP) were screened for in vitro glycemic indices (GI), α-amylase inhibition and anti-glycation activities. All four porridges had the medium GI values, those were in the range of 40.5 ± 4 to 63.9 ± 2. The highest antiglycation activity was reported for MWP demonstrating IC50 of 228.20 ± 4.20 µg/mL. In relation to the α-amylase inhibition activity, the porridge extracts of MWP and STP low IC50 values (117.54 ± 1.92 µg/mL and 128.75 ± 5.91 µg/mL) showed their high capability to inhibit α-amylase enzyme. Due to the medium to low GI values and high antiglycation and α-amylase inhibition activities, traditional rice based porridges can be considered as effective for the prevention of diabetic conditions as well as from various complications in diabetic patients. Anticancer activity against human lung and HeLa cell lines revealed that KHP and MXP exhibited anticancer activity (IC50 of 274.6 μg/mL and 940.2 μg/mL respectively) against HeLa- human cervical cancer cells. In conclusion, porridge composites prepared using Sri Lankan traditional rice helped to eliminate or notably reduce nutrient deficiencies, and it provided numerous health benefits and economical gains.
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The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
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Abbreviations
- MWP:
-
Madathawalu porridge
- KHP:
-
Kaluheenati porridge
- MXP:
-
Mixed rice porridge
- STP:
-
Special traditional porridge
- GI:
-
Glycemic index
- HI:
-
Hydrolysis index
References
Abeysekera W, Arachchige SPG, Ratnasooriya WD, Choudhary MI, Dalvandi K, Chandrasekharan NV (2015) Anti-diabetic related health food properties of traditional rice (Oryza sativa L.) in Sri Lanka. J Coast Life Med 3(10):815–820
Abeysekera W, Premakumara G, Dar A, Choudhary MI, Ratnasooriya W, Kashif M, Mudassar C, Ali S, Chandrasekharan N (2015) Growth inhibition and cytotoxicity in human lung and cervical cancer cell lines and glutathione S-transferase inhibitory activity of selected Sri Lankan traditional red rice (Oryza Sativa L.) Brans. J Food Biochem 39(5):585–593
Abeysekera W, Premakumara G, Ratnasooriya W (2013). In vitro antioxidant properties of leaf and bark extracts of Ceylon cinnamon (Cinnamomum zeylanicum Blume)
Alyami J, Whitehouse E, Yakubov GE, Pritchard SE, Hoad CL, Blackshaw E, Heissam K, Cordon SM, Bligh HFJ, Spiller RC (2019) Glycaemic, gastrointestinal, hormonal and appetitive responses to pearl millet or oats porridge breakfasts: a randomised, crossover trial in healthy humans. Br J Nutr 122(10):1142–1154
Anuruddhika Subhashinie Senadheera SP, Ekanayake S (2013) Green leafy porridges: how good are they in controlling glycaemic response? Int J Food Sci Nutr 64(2):169–174
Association AD (2014) Diagnosis and classification of diabetes mellitus. Diabetes Care 37(Supplement 1):S81–S90
Balasubramaniam V, Mustar S, Khalid NM, Rashed AA, Noh MFM, Wilcox MD, Chater PI, Brownlee IA, Pearson JP (2013) Inhibitory activities of three Malaysian edible seaweeds on lipase and α-amylase. J Appl Phycol 25(5):1405–1412
Bellmann S, Minekus M, Sanders P, Bosgra S, Havenaar R (2018) Human glycemic response curves after intake of carbohydrate foods are accurately predicted by combining in vitro gastrointestinal digestion with in silico kinetic modeling. Clin Nutr Exp 17:8–22
Goñi I, Garcia-Alonso A, Saura-Calixto F (1997) A starch hydrolysis procedure to estimate glycemic index. Nutr Res 17(3):427–437
Graidist P, Plongbunjong V, Wichienchot S, Madla S, Bunyapipat P, Knudsen K (2019) Isomalto-oligosaccharides from rice and their potential use as pharma-nutraceuticals in prevention of colon cancer. Funct Foods Health Dis 9(6):371–383
Grzegorczyk-Karolak I, Gołąb K, Gburek J, Wysokińska H, Matkowski A (2016) Inhibition of advanced glycation end-product formation and antioxidant activity by extracts and polyphenols from Scutellaria alpina L. and S. altissima L. Molecules 21(6):739
Hara Y, Honda M (1990) The inhibition of α-amylase by tea polyphenols. Agric Biol Chem 54(8):1939–1945
Hettiarachchi P, Jiffry M, Jansz E, Wickramasinghe A, Fernando D (2014) Glycaemic indices of different varieties of rice grown in Sri Lanka. Ceylon Med J 46(1):11
Horner M, Ries L, Krapcho M, Neyman N, Aminou R, Howlader N, Altekruse S, Feuer E, Huang L, Mariotto A (2009). SEER Cancer Statistics Review, 1975–2006, National Cancer Institute. Bethesda, MD
Jenkins D, Wolever T, Jenkins A, Thorne M, Lee R, Kalmusky J, Reichert R, Wong G (1983) The glycaemic index of foods tested in diabetic patients: a new basis for carbohydrate exchange favouring the use of legumes. Diabetologia 24(4):257–264
Jenkins DA, Jenkins A, Wolever TS, Josse R, Wong G (1984) The glycaemic response to carbohydrate foods. Lancet 324(8399):388–391
Kariyawasam T, Godakumbura P, Prashantha M, Premakumara G (2016) Proximate composition, calorie content and heavy metals (As, Cd, Pb) of selected Sri Lankan traditional rice (Oryza sativa L.) varieties. Procedia Food Sci 6:253–256
Katulanda P, Ranasinghe R, Jayawardana RS, Matthews DR (2012) Metabolic syndrome among Sri Lankan adults: prevalence, patterns and correlates. Diabetol Metab Syndr 4(1):1–10
Kumari D, Chandrasekara A, Athukorale P, Shahidi F (2020) Finger millet porridges subjected to different processing conditions showed low glycemic index and variable efficacy on plasma antioxidant capacity of healthy adults. Food Prod Process Nutr 2(1):1–11
Ma Y, Rang Y, Yang R, Zhao W (2018) Effect of white kidney bean extracts on estimated glycemic index of different kinds of porridge. LWT 96:576–582
Matsuura N, Aradate T, Sasaki C, Kojima H, Ohara M, Hasegawa J, Ubukata M (2002) Screening system for the Maillard reaction inhibitor from natural product extracts. J Health Sci 48(6):520–526
Onyango C, Wanjala GW (2018) Quality of porridge from sub-Saharan Africa evaluated using instrumental techniques and descriptive sensory lexicon. Part 2: thin porridge. Afr J Food Sci 12(5):104–114
Orellana EA, Kasinski AL (2016) Sulforhodamine B (SRB) assay in cell culture to investigate cell proliferation. Bio-protocol. https://doi.org/10.4038/tar.v22i1.2667
Pathiraje P, Madhujith W, Chandrasekara A, Nissanka S (2010). The effect of rice variety and parboiling on in vivo glycemic response
Pirasath S, Thayaananthan K, Balakumar S, Arasaratnam V (2010) Effect of dietary curries on the glycaemic index. Ceylon Med J 55(4):118
Premakumara G, Abeysekera W, Ratnasooriya W, Chandrasekharan N, Bentota A (2013) Antioxidant, anti-amylase and anti-glycation potential of brans of some Sri Lankan traditional and improved rice (Oryza sativa L.) varieties. J Cereal Sci 58(3):451–456
Rebecca S, Deepa N, Ahmedin J (2012) Cancer statistics, 2012. Ca Cancer J Clin 62(1):10–29
Sapra A, Bhandari P (2019). Diabetes mellitus
Schenker S (2012) An overview of the role of rice in the UK diet. Nutr Bull 37(4):309–323
Séro L, Sanguinet L, Blanchard P, Dang BT, Morel S, Richomme P, Séraphin D, Derbré S (2013) Tuning a 96-well microtiter plate fluorescence-based assay to identify AGE inhibitors in crude plant extracts. Molecules 18(11):14320–14339
Sohail M, Rakha A, Butt MS, Iqbal MJ, Rashid S (2017) Rice bran nutraceutics: a comprehensive review. Crit Rev Food Sci Nutr 57(17):3771–3780
Srikaeo K, Sopade PA (2010) Functional properties and starch digestibility of instant Jasmine rice porridges. Carbohyd Polym 82(3):952–957
Taslimi P, Aslan HE, Demir Y, Oztaskin N, Maraş A, Gulçin İ, Beydemir S, Goksu S (2018) Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia. Int J Biol Macromol 119:857–863
Thompson LU, Button CL, Jenkins D (1987) Phytic acid and calcium affect the in vitro rate of navy bean starch digestion and blood glucose response in humans. Am J Clin Nutr 46(3):467–473
Thushara P, Godakumbura P, Prashantha B (2019) IMPORTANCE, HEALTH BENEFITS AND BIOACTIVITIES OF SRI LANKAN TRADITIONAL RICE (Oryza sativa L.) VARIETIES: A REVIEW. Int J Agric Environ Biores 04:119–128. https://doi.org/10.35410/IJAEB.2019.119128
Thushara PAN, Godakumbura PI, Prashantha MB (2020) Agronomic characters and chemical composition of Sri Lankan novel red pericarp rice (Oryza sativa L.) variety. Int J Environ Agric Biotechnol 5(2):246–250
Verma DK, Srivastav PP (2020) Bioactive compounds of rice (Oryza sativa L.): review on paradigm and its potential benefit in human health. Trends Food Sci Technol 97:355–365
Woodruff S (2001) The Good Carb Cookbook: Secrets of Eating Low on the Glycemic Index, Penguin
Acknowledgements
The authors would like to thank Mr. P Gurusinghe and Mr. Piyasena (farmer’s association, Sri Lanka) for the information provided and Ms. Thiloka Kariyawasam for useful discussions.
Funding
This work was supported by the University of Sri Jayewardenepura [grant number ASP/01/RE/SCI/2017/54].
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NT: Conceptualization, Investigation, Methodology, Formal analysis, Data curation, Writing the manuscript. PM: Supervision, Review the manuscript. SRS: Resources, Data curation. PIG: Methodology, Conceptualization, Supervision, Review & editing the manuscript.
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Thushara, N., Malawiarachchi, P., Samarakoon, S.R. et al. Anti-diabetic and anti-cancer related health food properties of selected Sri Lankan traditional rice based porridges. J Food Sci Technol 59, 3745–3753 (2022). https://doi.org/10.1007/s13197-021-05341-9
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DOI: https://doi.org/10.1007/s13197-021-05341-9