Abstract
Inflammatory bowel disease, a typical chronic inflammatory disease of the gastrointestinal tract, make up a growing share of the global disease burden. This study firstly evaluated the anti-inflammatory effects of corn protein hydrolysate (CPH) using a cell model of tumor cell necrosis factor-α (TNF-α)-induced inflammation and a mouse model of colitis induced by dextran sodium sulfate. CPH digests significantly inhibited the expression of cyclooxygenase-2 and inducible nitric oxide synthase, and reduced the secretion of interleukin-8 in TNF-α-induced inflammation in Caco-2 cells. In mice, CPH digests significantly improved the body weight loss, clinical scores, shortening of the colon and histological symptoms, and decreased the myeloperoxidase activity, and down regulated the expression of TNF-α, and interleukin-6 in the colon. The above results indicate that the CPH can potentially be used as a health food/nutraceutical for the treatment/management of intestinal inflammation.
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Acknowledgements
The authors wish to express their appreciation for the support obtained from Grant of the Project of National 863 Plan of China (2013AA102203), National Natural Science Foundation of China (31801552), Jiangsu Province Key Research and Development Program (BE2018368), China Postdoctoral Science Foundation Special Funding Project (2018T110459) and Jiangsu Province Postdoctoral Science Foundation Special Funding Project (2019K114).
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Liang, Q., Ren, X., Chalamaiah, M. et al. Simulated gastrointestinal digests of corn protein hydrolysate alleviate inflammation in caco-2 cells and a mouse model of colitis. J Food Sci Technol 57, 2079–2088 (2020). https://doi.org/10.1007/s13197-020-04242-7
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DOI: https://doi.org/10.1007/s13197-020-04242-7