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Identification of bioactives from Astragalus chinensis L.f. and their antioxidant, anti-inflammatory and anti-proliferative effects

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Abstract

This work was designed to obtain the valuable compounds with antioxidant, anti-proliferative and anti-inflammatory activities from Astragalus chinensis. Ethyl acetate fraction obtained from A. chinensis L.f. had significant antioxidant, anti-proliferative and anti-inflammatory activities. Subsequently, five single compounds were separated and purified, which were identified as formononetin (1), rhamnocitrin (2), calycosin (3), β-daucosterol (4), rhamnocitrin-3-O-β-d-glucoside (5). The results displayed that formononetin and rhamnocitrin exhibited significant cytotoxicity actions against tumor cell lines. Calycosin exerted the strongest anti-inflammatory effect of inhibition effects on NO production in macrophages.

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Acknowledgements

This research was supported by the Science and Technology Project of Guangzhou City (201604020150), the National Natural Science Foundation of China (21702156), the Hubei Natural Science Foundation (2017CFB200) and the Scientific Research Foundation of Wuhan institute of technology (K201759).

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Authors and Affiliations

  1. School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China

    Ting Hu

  2. College of Food and Bioengineering, South China University of Technology, Guangzhou, 510640, China

    Ting Hu, Qi-Mei Liu, Xiao-Wei He & Jian-Guo Jiang

  3. Sericultural and Agri-food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou, 510610, China

    Fei Huang & Ming-Wei Zhang

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  1. Ting Hu
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  2. Qi-Mei Liu
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  3. Xiao-Wei He
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  4. Fei Huang
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  5. Ming-Wei Zhang
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Correspondence to Jian-Guo Jiang.

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Hu, T., Liu, QM., He, XW. et al. Identification of bioactives from Astragalus chinensis L.f. and their antioxidant, anti-inflammatory and anti-proliferative effects. J Food Sci Technol 54, 4315–4323 (2017). https://doi.org/10.1007/s13197-017-2902-3

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  • DOI: https://doi.org/10.1007/s13197-017-2902-3

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