Abstract
CD44 + /CD24 − phenotype has been associated with stem cell-like characteristics with enhanced invasive properties, radiation resistance, and with distinct genetic profiles suggesting a correlation to adverse prognosis in western literature. The aim of this study was to study CD44 + /CD24 − phenotype as an adverse prognostic marker in Indian breast cancer patients. N = 61 breast cancer patients included in a tertiary care facility in India were evaluated for receptor studies (estrogen receptor ER, progesterone receptor PR, Herceptin antibody Her2 neu receptor, CD44 & CD24 stem cell markers). CD44 + /CD24 − phenotype was statistically related to adverse factors like estrogen and progesterone receptors non-expression, her 2 neu expression, and triple-negative breast cancer. Of the 39 patients with ER-ve status, 33 (84.6%) were found to have CD44 + /CD24 − phenotype and 82.5% of all the CD 44 + /CD24 − patients were ER negative (p = 0.001). Thirty-four (75.5%) of the PR-ve patients showed the CD44 + /CD24 − phenotype, and of all the CD 44 + /CD24 − patients, 85% of were PR negative (p = 0.006). Thirty-six (75%) of Her-2-Neu + ve were CD44 + /CD24 − . Approximately 90% of the Her 2 Neu patients expressed CD44 + /CD24 − and 76.9% of all the triple-negative patients were found to be CD44 + /CD24 − expression (p = 0.001). CD44 + /CD24 − had a significant association with adverse prognostic factors like stage of disease, hormonal receptor status, and molecular subtypes in Indian breast cancer patients like the Western data.
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AkA, S. K., and A. A. S. designed the study. J. L. M., AkA, and K. R. S. were involved in acquisition of data. J. L. M., AkA, K. R. S., and N. H. did the analysis of data. K. G. and AkA drafted the manuscript. A. A. S., M. A., and S. K. critically revised and approved the final draft. AkA, P. A., and A. A. were involved in critical revision and manuscript editing. The manuscript has been read and approved by all the authors, that the requirements for authorship as stated in the instructions of the journal have been met, and that each author believes that the manuscript represents an honest work from this part of the world.
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The study was undertaken as a part of post-graduate thesis after approval from Ethics Committee, King George’s Medical University, Uttar Pradesh, India (Reg no. ECR/262/Inst/UP/2013/RR-19). All the patients were enrolled only after informed written consent post-ethics approval.
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Dr. K. G. and Dr. A. A. have shared co-first authorship of this paper since both have worked equally in conceptualizing the study, data analysis, preparation, and revising the manuscript. None of the authors has any conflicts of interests.
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Anand, A., Gaurav, K., Miller, J.L. et al. Clinicopathologic Correlation of CD44 + /CD24 − Expression in Breast Cancer: a Report from Tertiary Care Medical University in India. Indian J Surg Oncol 14, 204–207 (2023). https://doi.org/10.1007/s13193-022-01649-w
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DOI: https://doi.org/10.1007/s13193-022-01649-w