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ERCC2 rs13181 Polymorphism Association with Glioma Risk: an Update Meta-Analysis

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Abstract

Glioma is the most common type of primary brain tumour which accounts for about 30% of all brain and central nervous system tumours, and approximately 70% of adult malignant brain tumours. Numerous studies have been performed to assess the relationship between ERCC2 rs13181 polymorphism and the risk of glioma development, yet these findings of these studies are often inconsistent and contradictory. Therefore, the aim of this study is to conduct a systematic review and meta-analysis to assess the role of ERCC2 rs13181 in glioma developing. In this work, we have conducted a systematic review and meta-analysis. In order to collect the results of relevant studies on the association of ERCC2 rs13181 gene polymorphism with glioma, we initially searched the Scopus, Embase, Web of Science (WoS), PubMed, and ScienceDirect databases, without a lower time limit, and until June 2020. In order to analyse the eligible studies, the random effects model was used and the heterogeneity of the studies was investigated with the I2 index. Data analysis was performed within the Comprehensive Meta-Analysis software (version 2). The total number of studies that focused on patients with glioma was 10. The odds ratio of GG vs TT genotype in patients with glioma based on meta-analysis was 1.08 (0.85–1.37: 95% confidence interval), which indicates the increasing effect of GG vs TT genotype by 0.08. The odds ratio of GG + TG vs TT genotype in patients with glioma was 1.22 (1.38–1.7: 95% confidence interval) based on meta-analysis, which indicates the increasing effect of GG + TG vs TT genotype as 0.22. The odds ratio of TG vs TT genotype in patients with glioma was 1.2 (0.38–1.4: 95% confidence interval), which shows the increasing effect of TG vs TT genotype by 0.2. The odds ratio of G vs T genotype in patients with glioma based on the meta-analysis was 1.15 (1.26–1.4: 95% confidence interval), which indicates the increasing effect of G vs T genotype by 0.15. The odds ratio of GG vs TG + TT genotype in patients with glioma based on meta-analysis was 1.22 (1.33–1.45: 95% confidence interval), which indicates the increasing effect of GG vs TG + TT genotype by 0.22. The results of this systematic review and meta-analysis show that ERCC2 rs13181 polymorphism and its genotypes are an important risk factor for genetic susceptibility to glioma tumour.

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Data Availability

Datasets are available through the corresponding author upon reasonable request.

Abbreviations

STROBE:

Strengthening the Reporting of Observational Studies in Epidemiology for Cross-sectional Study

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-Analyses

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Acknowledgements

The authors thank the Student Research Committee of Nursing and Midwifery, Kermanshah University of Medical Sciences.

Author information

Authors and Affiliations

  1. Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Nader Salari

  2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Shna Rasoulpoor & Shervin Shabani

  3. Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Kamran Mansouri

  4. Faculty of Health and Life Sciences, School of Life Sciences, Coventry University, Coventry, UK

    Shadi Bokaee

  5. Department of Neurosurgery, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Reza Fatahian

  6. Department of Radiation Oncology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Negin Farshchian

  7. Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran

    Masoud Mohammadi

  8. Department of Food Science & Technology, Faculty of Agriculture, Ferdowsi University of Mashhad (FUM), Mashhad, Iran

    Melika Hosseinian-Far

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Contributions

NS, KM, RF, and NF contributed to the design. MM contributed to statistical analysis and participated in most of the study steps. SHR, SHSH, and MH prepared the manuscript. SHSH and SE assisted in designing the study and helped in the interpretation of the study. All authors have read and approved the content of the manuscript.

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Correspondence to Masoud Mohammadi.

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Ethics approval was received from the ethics committee of deputy of research and technology, Kermanshah University of Medical Sciences. This work adhered to the Declaration of Helsinki.

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Salari, N., Rasoulpoor, S., Shabani, S. et al. ERCC2 rs13181 Polymorphism Association with Glioma Risk: an Update Meta-Analysis. Indian J Surg Oncol 14, 60–68 (2023). https://doi.org/10.1007/s13193-022-01623-6

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