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Solid Pseudopapillary Neoplasm — Case Series and Review of Literature

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Abstract

Solid-pseudopapillary neoplasm (SPN) is a variety of solid and cystic tumors of the pancreas. It was first described by Frantz in 1959. It is an unusual form of pancreatic carcinoma, with unknown etiopathogenesis, which accounts for about 0.17 to 2.7% of all pancreatic tumors. Here, we are describing 5 cases of pancreatic solid pseudopapillary neoplasm, out of 180 pancreatic tumors, operated in our institution in the 5-year period (2015–2020). Also, we have reviewed all available case series (from 2006 to 2020) in the literature, of pancreatic pseudopapillary neoplasm, for demographic information, etiopathogenesis, diagnosis, and extent of operation to establish the optimal management of this condition. Retrospective analysis of pancreatic tumors was carried out from February 2015 to January 2020. A total of 180 patients underwent pancreatic resection in this period for pancreatic tumor, out of which, the solid pseudopapillary neoplasm was confirmed in 5 cases (2.76%). Among these 5 cases, 4 cases (80%) were female and one (20%) male, with age group range from 14 to 45 years (mean age — 28 years). Abdominal pain was the most frequent presenting symptom (60%). Mean tumor diameter was 6.9 cm (range, 2–18 cm). Two patients were diagnosed preoperatively by CECT and MRI findings, and three patients were diagnosed preoperatively by percutaneous/USG-guided and CT-guided FNA cytology. Two patients underwent pancreatoduodenectomy; one patient underwent enucleation; and two patients underwent spleen preserving distal pancreatectomy. Four patients are alive and on regular follow-up, while one patient died on the 5th post-operative day due to post-operative sepsis.

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Abbreviations

SNP:

Solid pseudopapillary neoplasm

CT:

Computed tomography

CECT:

Contrast-enhanced computed tomography

EUS:

Endoscopic ultrasound

FNAC:

Fine-needle aspiration cytology

MRI:

Magnetic resonance imaging

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Authors and Affiliations

  1. Department of Surgery, ABVIMS and Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India

    Lalit Kumar Bansal, Neeti Kapur, Arun Kumar Gupta, Ashutosh Nagpal & Poras Chaudhary

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  1. Lalit Kumar Bansal
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  2. Neeti Kapur
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Correspondence to Lalit Kumar Bansal.

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Bansal, L.K., Kapur, N., Gupta, A.K. et al. Solid Pseudopapillary Neoplasm — Case Series and Review of Literature. Indian J Surg Oncol 13, 765–775 (2022). https://doi.org/10.1007/s13193-022-01560-4

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