Abstract
Solid pseudopapillary neoplasm is a rare tumor of the pancreas. These tumors are considered to have low malignant potential with good prognosis. Due to its rarity, details about clinical presentation and management of the disease are not very clear. This study aims to share our experience and to describe management of the disease. We retrospectively evaluated patients 13 patients diagnosed with SPT on histopathological examination of resected specimen. Data on their clinicopathological, management-related factors, and follow-up was collected. All the patients were females, with a median age of 20 years. Abdominal pain was the most common presentation. The mean tumor size was 6.5 cm and majority of tumors were located in the head region. R0 resection was obtained in all the patients. All patients were disease-free with a median follow-up of 68 months. Excellent prognosis can be achieved with a margin-negative resection in these tumors. Adjacent organ or vascular involvement is not a contraindication for surgical resection.
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Kloppel G, Solcia E, Longnecker DS, et al (1996) Histological typing of tumors of the exocrine pancreas: World Health Organization international histological classification of tumors, ed 2. New York, Springer-Verlag;123:14, 20
Papavramidis T, Papavramidis S (2005) Solid pseudopapillary tumours of the pancreas: review of 718 patients reported in english literature. J Am Coll Surg 200:965–972
Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, Neoptolemos J, Sarr M, Traverso W, Buchler M, International Study Group on Pancreatic Fistula Definition (2005) Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 138(1):8–13
Casadei R, Santini D, Calculli L, Pezzilli R, Zanini N, Minni F (2006) Pancreatic solid-cystic papillary tumor: clinical features, imaging findings and operative management. JOP 7:137–144
Lam KY, Lo CY, Fan ST (1999) Pancreatic solid-cystic-papillary tumor: clinicopathologic features in eight patients from Hong Kong and review of the literature. World J Surg 23:1045–1050
Patil TB, Shrikhande SV, Kanhere HA, Saoji RR, Ramadwar MR, Shukla PJ (2006) Solid pseudopapillary neoplasm of the pancreas: a single institution experience of 14 cases. HPB : The Off J Int Hepato Pancreato Biliary Association 8(2):148–150
Lack EE, Cassady JR, Levey R, Vawter GF (1983) Tumors of the exocrine pancreas in children and adolescents. A clinical and pathologic study of eight cases. Am J Surg Pathol 7:319–327
Patnayak R, Jena A, Parthasarathy S, Vijaylaxmi B, Lakshmi AY, Rukmangadha N, Chowhan AK, Phaneendra BV, Reddy MK (2013) Solid and cystic papillary neoplasm of pancreas: a clinic-pathological and immunohistochemical study: a tertiary care center experience. South Asian J Cancer 2:153–157
Shaikh S, Arya S, Ramadwar M, Barreto SG, Shukla PJ, Shrikhande SV (2008) Three cases of unusual solid pseudopapillary tumors. Can radiology and histology aid decision-making? JOP 9:150–159
Yu PF, Hu ZH, Wang XB, Guo JM, Cheng XD, Zhang YL, Xu Q (2010 Mar 14) Solid pseudopapillary tumor of the pancreas: a review of 553 cases in Chinese literature. World J Gastroenterol 16(10):1209–1214
Kamat RN, Naik LD, Joshi RM, Amrapurkar AD, Shetty TS (2008) Solid pseudopapillary tumor of the pancreas. Indian J Pathol Microbiol 51:271–273
Wani NA, Lone TK, Shah AI, Khan AQ, Malik RA (2011) Malignant solid pseudopapillary tumor of pancreas causing sinistral portal hypertension. Indian J Pathol Microbiol 54:152–155
Coleman KM, Doherty MC, Bigler SA et al (2003) Solid-pseudopapillary tumor of the pancreas. Radiographics 23:1644–1648
Cantisani V, Mortele KJ, Levy A, Glickman JN, Ricci P, Passariello R, Ros PR, Silverman SG (2003) MR imaging features of solid pseudopapillary tumor of the pancreas in adult and pediatric patients. AJR Am J Roentgenol 181:395–/401
Santini D, Poli F, Lega S (2006) Solid-papillary tumors of the pancreas: histopathology. JOP 7:131–136
Mehta N, Modi L, Patel T, Shah M (2010) Study of cytomorphology of solid pseudopapillary tumor of pancreas and its differential diagnosis. J Cytol 27:118–122
Lubezky N, Papoulas M, Lessing Y, Gitstein G, Brazowski E, Nachmany I, Lahat G, Goykhman Y, Ben-Yehuda A, Nakache R, Klausner JM (2017 Jun 30) Solid pseudopapillary neoplasm of the pancreas: management and long-term outcome. Eur J Surg Oncol (EJSO) 43(6):1056–1060
Jeng LBB, Chen MF, Tang RP (1993) Solid and papillary neoplasm of the pancreas: emphasis on surgical treatment. Arch Surg 128:433–436
Martin RC, Klimstra DS, Brennan MF, Conlon KC (2002) Solid-pseudopapillary tumor of the pancreas: a surgical enigma? Ann Surg Oncol 9:35–40
El Nakeeb A, Wahab MA, Elkashef WF, Azer M, Kandil T (2013) Solid pseudopapillary tumour of the pancreas: incidence, prognosis and outcome of surgery (single center experience). Int J Surg 11(6):447–457
Kanter J, Wilson DB, Strasberg S (2009 Oct 1) Downsizing to resectabilty of a large solid and cystic papillary tumor of the pancreas by single-agent chemotherapy. J Pediatr Surg 44(10):e23–e25
Das G, Bhuyan C, Das BK, Sharma JD, Saikia BJ, Purkystha J (2004) Spleen-preserving distal pancreatectomy following neoadjuvant chemotherapy for papillary solid and cystic neoplasm of pancreas. Ind J Gastroenterol: Off J Indian Soc Gastroenterol 23(5):188–189
Nishihara K, Nagoshi M, Tsuneyoshi M, Yamaguchi K, Hayashi I (1993) Papillary cystic tumors of the pancreas. Assessment of their malignant potential. Cancer 71:82–92
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Sachan, A., Nag, H.H., Nischal, N. et al. Solid Pseudopapillary Neoplasm of the Pancreas Clinicopathological Characteristics and Long-Term Outcome: a Single-Center Experience. Indian J Surg Oncol 9, 483–487 (2018). https://doi.org/10.1007/s13193-018-0775-1
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DOI: https://doi.org/10.1007/s13193-018-0775-1