EPMA Journal

pp 1–12

Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach?

  • Pavol Zubor
  • Alexandra Gondova
  • Jiri PolivkaJr
  • Petra Kasajova
  • Katarzyna Konieczka
  • Jan Danko
  • Olga Golubnitschaja
Research

DOI: 10.1007/s13167-017-0089-3

Cite this article as:
Zubor, P., Gondova, A., Polivka, J. et al. EPMA Journal (2017). doi:10.1007/s13167-017-0089-3

Abstract

An epidemic scale of the breast cancer (BC) prevalence is actually recognised as the reality of the early twenty-first century. Particularly alarming is that the sporadic BC (about 90% of all patients) creates currently unpredictable subpopulations in terms of disease predisposition, development and progression. Despite broad discussions run since years in BC area, no any plausible approach has been suggested so far to get the overall situation better controlled in the populations. Here, we present highly innovative concepts considering investigation of specific syndromes and symptoms underestimated till now in relationship with BC predisposition and development. Consequently, the purpose of our pilot project was to evaluate the prevalence of Flammer Syndrome (FS) in BC patient cohort. The results achieved here support the main hypothesis of the project clearly demonstrating the tendency of BC patients to the increased prevalence of FS symptoms compared to the disease-free individuals. Our study strongly indicates the relevance of FS symptoms for BC pathology such as feeling inadequately cold, deficient thermoregulation, altered sensitivity to different stimuli, potential dehydration, altered sleep patterns, tendency towards headache, migraine attacks and dizziness. Moreover, the symptoms’ appearance is specifically linked to the individual BC subtypes. Potential mechanisms interconnecting FS with BC pathology are discussed.

Keywords

Predictive preventive personalised medicine Breast cancer Flammer syndrome Systemic hypoxia Patient stratification Pain Thermoregulation Cardiovascular component Drug sensitivity Sense regulation 

Copyright information

© European Association for Predictive, Preventive and Personalised Medicine (EPMA) 2017

Authors and Affiliations

  • Pavol Zubor
    • 1
    • 2
  • Alexandra Gondova
    • 1
  • Jiri PolivkaJr
    • 3
    • 4
  • Petra Kasajova
    • 1
  • Katarzyna Konieczka
    • 5
  • Jan Danko
    • 1
  • Olga Golubnitschaja
    • 6
    • 7
    • 8
  1. 1.Department of Obstetrics and Gynaecology, Jessenius Faculty of MedicineMartin University HospitalMartinSlovak Republic
  2. 2.Division of Oncology, Biomedical Centre Martin, Jessenius Faculty of MedicineComenius University in BratislavaBratislavaSlovak Republic
  3. 3.Department of Histology and Embryology and Biomedical Center, Faculty of Medicine in PlzenCharles UniversityPragueCzech Republic
  4. 4.Department of NeurologyFaculty Hospital PlzenPragueCzech Republic
  5. 5.Department of OphthalmologyUniversity of BaselBaselSwitzerland
  6. 6.Radiological clinicRheinische Friedrich-Wilhelms-University of BonnBonnGermany
  7. 7.Breast Cancer Research CentreRheinische Friedrich-Wilhelms-University of BonnBonnGermany
  8. 8.Centre for Integrated Oncology, Cologne-BonnRheinische Friedrich-Wilhelms-University of BonnBonnGermany

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