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The Influence of H2-Receptor Antagonist Administration to the 24-h Uptake of I-131 in the Thyroid Gland

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Abstract

Purpose

The aim of this study was to determine the influence of H2RAs to the 24-h I-131 uptake in the thyroid gland.

Material and Methods

A prospective study with quasi-experimental pre- and post-study design was done. Subjects with normal fT4 level who fulfilled the inclusion criteria were selected. All subjects received 0.2 mCi of I-131 orally, and the thyroid uptake calculations were performed at 24 h later. The same procedure was performed 4 weeks later. All of the subjects were asked to consume H2RAs 1 h before the administration of I-131 of the second procedure. Both 24-h thyroid uptakes were statistically analysed.

Results

A total of 14 subjects were enrolled in this study. Most of them were women (78%) with an average age of 37.6 years old (range: 20–55). This study showed a median of 24-h thyroid uptake of I-131 before and after H2-receptor antagonist of 20.6% (range: 11.1–57.8%) and 16.7% (range: 8.1–39.4%) respectively.

Conclusion

H2-receptor antagonist caused a significance reduction of 24-h I-131 uptake value in the thyroid gland.

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Authors and Affiliations

  1. Department of Nuclear Medicine and Molecular Imaging, Dr. Hasan Sadikin General Hospital Bandung, Pasirkaliki 192, Sukajadi, Pasteur, Bandung, West Java, 40161, Indonesia

    Andreas Lim & A. Hussein S. Kartamihardja

  2. Universitas Padjadjaran Bandung, Bandung, Indonesia

    Andreas Lim, Hendra Budiawan & A. Hussein S. Kartamihardja

Authors
  1. Andreas Lim
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  2. Hendra Budiawan
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  3. A. Hussein S. Kartamihardja
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Corresponding author

Correspondence to Andreas Lim.

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Conflict of Interest

Andreas Lim, Hendra Budiawan and Achmad Hussein Sundawa Kartamihardja declare that they have no conflict of interest.

Ethical Approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of Dr. Hasan Sadikin General Hospital Bandung and had been approved by the Ethical Committee (Number: LB.02.01/X.6.5/195/2019).

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Lim, A., Budiawan, H. & Kartamihardja, A.H.S. The Influence of H2-Receptor Antagonist Administration to the 24-h Uptake of I-131 in the Thyroid Gland. Nucl Med Mol Imaging 55, 27–30 (2021). https://doi.org/10.1007/s13139-020-00676-1

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  • DOI: https://doi.org/10.1007/s13139-020-00676-1

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