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Long-term abdominal adiposity activates several parameters of cardiac energy function

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Abstract

Abdominal obesity increases the incidence of cardiac events but reduces mortality when one of these events occurs. The phenomenon called obesity paradox might be related to myocardial energetics. This study was aimed at determining whether long-term abdominal adiposity alters cardiac energy function. Two groups of male Wistar rats were fed a standard or a Western-type (WD) diet for 8 months. The ex vivo coronary reactivity and mechanical function as well as the mitochondrial oxidative phosphorylation (mOxPhos) and hydrogen peroxide release (mH2O2r) were determined. Abdominal adiposity was augmented by the WD. This was also the case for the coronary reactivity to acetylcholine, but the rate pressure product remained roughly stable despite a reduction of the left ventricle-developed pressure partly compensated by a slight increase in heart rate. The prolonged WD administration resulted in an improvement of mOxPhos, but the mH2O2r was exaggerated which was confirmed in the whole cell by a reduced aconitase to fumarase ratio. This did not modify the plasma oxidative stress due to an increased plasma antioxidant status. In conclusion, long-term WD administration improved the cardiac fitness and might predispose the organism to the obesity paradox. Conversely, the increased mitochondrial mH2O2r can precipitate the heart toward cardiomyopathy if the WD is maintained for a longer duration.

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Acknowledgments

The work was supported by the French National Institute of Agronomical Research (INRA), National Institute of Health and Medical Research (INSERM), and Joseph Fourier University of Grenoble.

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Authors and Affiliations

  1. Laboratoire de Bioénergétique Fondamentale et Appliquée, INSERM U1055, 38041, Grenoble cedex 09, France

    Evangelia Mourmoura, Karine Couturier, Isabelle Hininger & Luc Demaison

  2. Laboratoire de Bioénergétique Fondamentale et Appliquée, Université Joseph Fourier, 38041, Grenoble cedex 09, France

    Evangelia Mourmoura, Karine Couturier, Isabelle Hininger & Luc Demaison

  3. Unité de Nutrition Humaine, INRA, UMR 1019, Clermont Université, Université d’Auvergne, BP 10448, 63000, Clermont-Ferrand, France

    Jean-Paul Rigaudière, Brigitte Laillet, Corinne Malpuech-Brugère & Luc Demaison

  4. Clermont-Ferrand University Hospital, Heart Surgery Department, G. Montpied Hospital, 63000, Clermont-Ferrand, France

    Kasra Azarnoush

Authors
  1. Evangelia Mourmoura
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  2. Jean-Paul Rigaudière
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  3. Karine Couturier
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  4. Isabelle Hininger
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  5. Brigitte Laillet
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  6. Corinne Malpuech-Brugère
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  7. Kasra Azarnoush
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  8. Luc Demaison
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Correspondence to Luc Demaison.

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Mourmoura, E., Rigaudière, JP., Couturier, K. et al. Long-term abdominal adiposity activates several parameters of cardiac energy function. J Physiol Biochem 72, 525–537 (2016). https://doi.org/10.1007/s13105-015-0427-7

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  • DOI: https://doi.org/10.1007/s13105-015-0427-7

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