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Nonmicrobial-mediated inflammatory airway diseases—an update

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Abstract

In lungs, airways are in constant contact with air, microbes, allergens, and environmental pollutants. The airway epithelium represents the first line of lung defense through different mechanisms, which facilitate clearance of inhaled pathogens and environmental particles while minimizing an inflammatory response. The innate immune system facilitates immediate recognition of both foreign pathogens and tissue damage through toll-like receptor, which acts as a gateway for all intracellular events leading to inflammation. In the absence of microbial stimulus, the immune system is capable of detecting a wide range of insults against the host. This review focuses on various molecular mechanisms involved in pathophysiology of airway inflammation mediated by environmental factors, cellular stress, and pharmacological and clinical agents.

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Acknowledgments

The authors thank the management, faculties and staffs of Bharath University, Chennai, India for their support and encouragement.

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  1. Department of Bioinformatics, Bharath University, Selaiyur, Chennai, India

    Polani B. Ramesh Babu & P. Krishnamoorthy

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Correspondence to Polani B. Ramesh Babu.

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Ramesh Babu, P.B., Krishnamoorthy, P. Nonmicrobial-mediated inflammatory airway diseases—an update. J Physiol Biochem 70, 263–270 (2014). https://doi.org/10.1007/s13105-013-0297-9

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