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6-hydroxy-l-nicotine from Arthrobacter nicotinovorans sustain spatial memory formation by decreasing brain oxidative stress in rats

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Abstract

Male Wistar rats were subjected to chronic 6-hydroxy-l-nicotine treatment (6HLN, 0.3 mg/kg, i.p., seven consecutive days) and their memory performance was studied by means of Y-maze and radial arm-maze tasks. 6HLN significantly increased spontaneous alternations in Y-maze task and working memory in radial arm-maze task, suggesting effects on short-term memory, without affecting long-term memory, explored by reference memory in radial arm-maze task. In addition, 6HLN increased antioxidant enzymes activity and decreased production of lipid peroxidation, suggesting antioxidant effects. Also, the linear regression between behavioral measures and oxidative stress markers resulted in significant correlations. Therefore, positive effects of 6HLN on spatial memory may occur by antioxidant actions.

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Acknowledgments

Marius Mihasan was supported by CNCSIS-UEFISCSU, project number PN-II-RU 337/2010.

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Authors and Affiliations

  1. Department of Biology, Alexandru Ioan Cuza University, B-dul Carol I, No. 11, 700506, Iasi, Romania

    Lucian Hritcu, Marius Stefan & Marius Mihasan

  2. Institute of Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Biology, Albert-Ludwigs-University Freiburg, Hermann Herder Strasse 7, Freiburg, Germany

    Roderich Brandsch

Authors
  1. Lucian Hritcu
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  2. Marius Stefan
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  3. Roderich Brandsch
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  4. Marius Mihasan
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Correspondence to Lucian Hritcu.

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Lucian Hritcu, Marius Stefan, and Marius Mihasan equally contributed to this work

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Hritcu, L., Stefan, M., Brandsch, R. et al. 6-hydroxy-l-nicotine from Arthrobacter nicotinovorans sustain spatial memory formation by decreasing brain oxidative stress in rats. J Physiol Biochem 69, 25–34 (2013). https://doi.org/10.1007/s13105-012-0184-9

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