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Mesenchymal Stem Cell-Mediated Mitochondrial Transfer: a Therapeutic Approach for Ischemic Stroke

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Abstract

Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction is one of the hallmarks of stroke-induced neuronal death, and maintaining mitochondrial function is essential in cell survival and neurological progress following ischemic stroke. Stem cell-mediated mitochondrial transfer represents an emerging therapeutic approach for ischemic stroke. Accumulating evidence suggests that mesenchymal stem cells (MSCs) can directly transfer healthy mitochondria to damaged cells, and rescue mitochondrial damage-provoked tissue degeneration. This review summarizes the research on MSCs-mediated mitochondrial transfer as a therapeutic strategy against ischemic stroke.

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Authors and Affiliations

  1. Academy of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou, 450046, China

    Meng Lu & Yuhui Zhou

  2. Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Shijiazhuang, 050091, China

    Meng Lu, Jindong Guo, Bowen Wu, Yuhui Zhou & Mishan Wu

  3. Department of Formulaology, Basic Medicine College, Hebei University of Chinese Medicine, Shijiazhuang, 050200, China

    Meng Lu, Jindong Guo, Yuhui Zhou & Mishan Wu

  4. Department of Biochemistry, Basic Medicine College, Hebei University of Chinese Medicine, Shijiazhuang, 050200, China

    Bowen Wu

  5. Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Maryam Farzaneh & Seyed Esmaeil Khoshnam

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  1. Meng Lu
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  2. Jindong Guo
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  3. Bowen Wu
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  4. Yuhui Zhou
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  5. Mishan Wu
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  6. Maryam Farzaneh
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  7. Seyed Esmaeil Khoshnam
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Correspondence to Mishan Wu or Seyed Esmaeil Khoshnam.

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Lu, M., Guo, J., Wu, B. et al. Mesenchymal Stem Cell-Mediated Mitochondrial Transfer: a Therapeutic Approach for Ischemic Stroke. Transl. Stroke Res. 12, 212–229 (2021). https://doi.org/10.1007/s12975-020-00853-6

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  • DOI: https://doi.org/10.1007/s12975-020-00853-6

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