Skip to main content
Log in

Stroke Cytoprotection: Can Repeating History with New Expectations Really Be the Path to Success in Stroke Research?

  • Letter to the Editor
  • Published:
Translational Stroke Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Henninger N, Fisher M. Extending the time window for endovascular and pharmacological reperfusion. Transl Stroke Res. 2016;7(4):284–93.

    Article  CAS  PubMed  Google Scholar 

  2. Linfante I, Cipolla MJ. Improving reperfusion therapies in the era of mechanical thrombectomy. Transl Stroke Res. 2016;7(4):294–302.

    Article  PubMed  Google Scholar 

  3. Lyden P, Weymer S, Coffey C, Cudkowicz M, Berg S, O’Brien S, et al. Selecting patients for intra-arterial therapy in the context of a clinical trial for neuroprotection. Stroke. 2016; doi:10.1161/STROKEAHA.116.013881.

    PubMed Central  Google Scholar 

  4. Lapchak PA. Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection. Transl Stroke Res. 2015;6(5):345–54.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Pena ID, Borlongan C, Shen G, Davis W. Strategies to extend thrombolytic time window for ischemic stroke treatment: an unmet clinical need. J Stroke. 2017;19(1):50–60.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Jovin TG, Albers GW, Liebeskind DS, Consortium SI. Stroke treatment academic industry roundtable: the next generation of endovascular trials. Stroke. 2016;47(10):2656–65.

    Article  PubMed  Google Scholar 

  7. Lees KR, Zivin JA, Ashwood T, Davalos A, Davis SM, Diener HC, et al. NXY-059 for acute ischemic stroke. N Engl J Med. 2006;354(6):588–600.

    Article  CAS  PubMed  Google Scholar 

  8. Diener HC, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, et al. NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II trials. Stroke. 2008;39(6):1751–8.

    Article  CAS  PubMed  Google Scholar 

  9. Hacke W, Schellinger PD, Albers GW, Bornstein NM, Dahlof BL, Fulton R, et al. Transcranial laser therapy in acute stroke treatment: results of neurothera effectiveness and safety trial 3, a phase III clinical end point device trial. Stroke. 2014;45(11):3187–93.

    Article  PubMed  Google Scholar 

  10. Saver JL, Starkman S, Eckstein M, Stratton S, Pratt F, Hamilton S, et al. Methodology of the Field Administration of Stroke Therapy - Magnesium (FAST-MAG) phase 3 trial: part 2—prehospital study methods. Int J Stroke. 2014;9(2):220–5.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Fisher M. Recommendations for advancing development of acute stroke therapies: stroke therapy academic industry roundtable 3. Stroke. 2003;34(6):1539–46.

    Article  CAS  PubMed  Google Scholar 

  12. Stroke Therapy Academic Industry Roundtable (STAIR). Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke. 1999;30(12):2752–8.

  13. Lapchak PA. Recommendations and practices to optimize stroke therapy: developing effective translational research programs. Stroke. 2013;44(3):841–3.

    Article  PubMed  Google Scholar 

  14. Lapchak PA, Zhang JH, Noble-Haeusslein LJ. RIGOR guidelines: escalating STAIR and STEPS for effective translational research. Transl Stroke Res. 2013;4(3):279–85.

    Article  PubMed  Google Scholar 

  15. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, National Centre for the Replacement R, et al. Animal research: reporting in vivo experiments--the ARRIVE guidelines. J Cereb Blood Flow Metab. 2011;31(4):991-3.

  16. Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother. 2010;1(2):94-9.

  17. Zivin JA, Fisher M, DeGirolami U, Hemenway CC, Stashak JA. Tissue plasminogen activator reduces neurological damage after cerebral embolism. Science. 1985;230(4731):1289.

    Article  CAS  PubMed  Google Scholar 

  18. Lapchak PA. A clinically relevant rabbit embolic stroke model for acute ischemic stroke therapy development: mechanisms & targets. In: Lapchak PA, Zhang JH, editors. Translational stroke research: from target selection to clinical trials. USA: Springer; 2011.

    Google Scholar 

  19. Lapchak PA. A cost-effective rabbit embolic stroke bioassay: insight into the development of acute ischemic stroke therapy. Transl Stroke Res. 2015;6(2):99–103.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Lapchak PA. Translational stroke research using a rabbit embolic stroke model: a correlative analysis hypothesis for novel therapy development. Translational Stroke Research. 2010;1(2):96–107.

    Article  PubMed  PubMed Central  Google Scholar 

  21. NINDS. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333(24):1581–7.

    Article  Google Scholar 

  22. Berkhemer OA, Fransen PS, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372(1):11-20.

  23. Goyal M, Demchuk AM, Menon BK, Eesa M, Rempel JL, Thornton J, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372(11):1019-30.

  24. Jovin TG, Chamorro A, Cobo E, de Miquel MA, Molina CA, Rovira A, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015;372(24):2296-306.

  25. Saver JL, Goyal M, Bonafe A, Diener HC, Levy EI, Pereira VM, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015;372(24):2285-95.

  26. Campbell BC, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372(11):1009-18.

  27. Lyden P, Weymer S, Coffey C, Cudkowicz M, Berg S, O'Brien S, et al. Selecting patients for intra-arterial therapy in the context of a clinical trial for neuroprotection. Stroke. 2016;47(12):2979–85.

    Article  CAS  PubMed  Google Scholar 

  28. Uteshev VV. Editorial: Effective and promising treatments for neurological disorders and cancer. Curr Pharm Des. 2016;22(14):1979–80.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements and Funding

This article was written without direct financial support from government sources (PAL). PAL is supported by pharmaceutical industry grants and philanthropic donations. VVU is currently supported by the William and Ella Owens Medical Research Foundation.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paul A. Lapchak.

Ethics declarations

Conflict of Interest

PAL is the Editor-in-Chief, Journal of Neurology & Neurophysiology and Associate Editor, Translational Stroke Research.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lapchak, P.A., Uteshev, V.V. Stroke Cytoprotection: Can Repeating History with New Expectations Really Be the Path to Success in Stroke Research?. Transl. Stroke Res. 8, 104–106 (2017). https://doi.org/10.1007/s12975-017-0528-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12975-017-0528-4

Keywords

Navigation