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Is There a Place for Cerebral Preconditioning in the Clinic?

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Abstract

Preconditioning (PC) describes a phenomenon whereby a sub-injury-inducing stress can protect against a later injurious stress. Great strides have been made in identifying the mechanisms of PC-induced protection in animal models of brain injury. While these may help elucidate potential therapeutic targets, there are questions over the clinical utility of cerebral PC, primarily because of questions over the need to give the PC stimulus prior to the injury, narrow therapeutic windows, and safety. The object of this review is to address the question of whether there may indeed be a clinical use for cerebral PC and to discuss the deficiencies in our knowledge of PC that may hamper such clinical translation.

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Acknowledgments

This work was supported by the National Institutes of Health grants NS34709 (RFK), NS054724 (MMW), and NS039866 (GX). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Richard F. Keep, Michael M. Wang, Jianming Xiang, Ya Hua & Guohua Xi

  2. Department of Neurology, University of Michigan, Ann Arbor, MI, USA

    Michael M. Wang

  3. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA

    Richard F. Keep

  4. University of Michigan, R5018 Biomedical Science Research Building, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA

    Richard F. Keep

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  1. Richard F. Keep
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  5. Guohua Xi
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Correspondence to Richard F. Keep.

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Keep, R.F., Wang, M.M., Xiang, J. et al. Is There a Place for Cerebral Preconditioning in the Clinic?. Transl. Stroke Res. 1, 4–18 (2010). https://doi.org/10.1007/s12975-009-0007-7

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  • DOI: https://doi.org/10.1007/s12975-009-0007-7

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