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Antithrombotic therapy after transcatheter aortic valve replacement

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Abstract

Aortic stenosis is a major valvular disease, which affects prognosis, and its prevalence is increasing due to an aging population. Transcatheter aortic valve replacement (TAVR) is a well-established therapy for symptomatic severe aortic stenosis across the entire risk spectrum, and the number of patients who undergo TAVR is increasing worldwide. Generally, ischemic and bleeding events after TAVR are not rare and can be devastating. Thus, antithrombotic therapy is recommended to prevent thromboembolic events after TAVR. Recently, a lot of randomized control trials have been published on antithrombotic therapy following TAVR, and the situation regarding the optimal antithrombotic regiment following TAVR is dramatically changing. This report reviews the current status and remaining issues in the field of optimal antithrombotic therapy following TAVR and leaflet thrombosis.

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Acknowledgements

The authors thank all investigators and centers that participated in the OCEAN-TAVI registry.

Funding

The OCEAN-TAVI registry was supported by Edwards Lifesciences, Abbott, Medtronic, Boston Scientific, and Daiichi-Sankyo Company.

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Authors and Affiliations

  1. Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo, 160-8582, Japan

    Yusuke Kobari, Taku Inohara & Kentaro Hayashida

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  1. Yusuke Kobari
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  2. Taku Inohara
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  3. Kentaro Hayashida
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the OCEAN-TAVI Registry

Contributions

YK, TI, and KH had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Kobari, Inohara, and Hayashida. Acquisition, analysis, or interpretation of data: Kobari, Inohara, and Hayashida. Drafting of the manuscript: Kobari, Inohara, and Hayashida. Critical revision of the manuscript for important intellectual content: Kobari, Inohara, and Hayashida. Study supervision: Kobari, Inohara, and Hayashida.

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Correspondence to Kentaro Hayashida.

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Dr. Hayashida is a clinical proctor for Edwards Lifesciences, Medtronic, and Abbott Medical Japan.

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Kobari, Y., Inohara, T., Hayashida, K. et al. Antithrombotic therapy after transcatheter aortic valve replacement. Cardiovasc Interv and Ther 38, 9–17 (2023). https://doi.org/10.1007/s12928-022-00893-9

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