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Antiplatelet therapy after percutaneous coronary intervention: current status and future perspectives

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Abstract

Antiplatelet therapy after percutaneous coronary intervention (PCI) has been changing in parallel with the development of drug-eluting stents (DES) and antiplatelet agents. The recommendation of dual antiplatelet therapy duration is getting shorter due to the decreased risk of stent thrombosis in new-generation DES, the use of a P2Y12 inhibitor as a monotherapy, and the increasing prevalence of high bleeding risk patients. Antithrombotic therapy after PCI has also changed due to the introduction of direct oral anticoagulants. Aspirin-free P2Y12 inhibitor monotherapy is now being evaluated in several prospective studies as a novel strategy of antiplatelet therapy after PCI. This review shows a current status and provides future perspectives for the antiplatelet therapy after PCI.

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  1. Department of Cardiovascular Medicine, Saga University Hospital, 5-1-1 Nabeshima, Saga, 849-8501, Japan

    Masahiro Natsuaki, Shinjo Sonoda, Goro Yoshioka, Hiroshi Hongo, Tetsuya Kaneko, Kuninobu Kashiyama, Kensuke Yokoi & Koichi Node

  2. Cardiovascular Center, Saga Medical Center, Koseikan, Saga, Japan

    Yutaka Hikichi

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  1. Masahiro Natsuaki
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Natsuaki, M., Sonoda, S., Yoshioka, G. et al. Antiplatelet therapy after percutaneous coronary intervention: current status and future perspectives. Cardiovasc Interv and Ther 37, 255–263 (2022). https://doi.org/10.1007/s12928-022-00847-1

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