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Preparation and characterization of collagen coated cholesterol-free liposome nanoparticles matrix for drug carriers and tissue engineering application

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Abstract

The collagen coated cholesterol (CH)-free liposome nanoparticle (CCLNP) matrix has been prepared and characterized for use as therapeutic drug carriers, tissue engineering and regenerative medicinal applications. The CH-free liposome nanoparticle (LNP) was prepared by heating method under the N2 atmosphere and CCLNP matrix was prepared by incubation of bovine Achilles tendon collagen with preformed CH-free LNP. The results indicate that collagen stabilizes the original liposomal structure, and CCLNP are more stable in vitro than control liposome. This mineralized collagen composite matrix could be useful to bone and dental implants.

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References

  1. Lee K Y and Yuk S H, Prog Polym Sci 32 (2007) 669.

    Article  CAS  Google Scholar 

  2. Madrigal-Carballo S, Lim S, Rodriguez G, Vila A O, Krueger C G, Gunasekaran S and Reed J D, J Functional Foods 2 (2010) 99.

    Article  CAS  Google Scholar 

  3. Gotoh T and Hozawa M, Biotechnol Lett 26 (2004) 611.

    Article  CAS  Google Scholar 

  4. Wang P, Zhao W, Su S, Wang Z, Liao R, Niu, and Chang J, Biomaterials 31 (2010) 8741.

    Article  CAS  Google Scholar 

  5. Shabbits J A, Chiu G N C and Mayer L D, J Control Release 84 (2002) 161.

    Article  CAS  Google Scholar 

  6. Laye C, McClements D J and Weiss J, J Food Sci 73 (2008) N7–N15.

    Article  CAS  Google Scholar 

  7. Singh C U, United States Patent No. 7179484 (2007).

  8. Gobin A S, Rhea R, Newman R A and Mathur A B, Int J Nanomed 1 (2006) 81.

    Article  CAS  Google Scholar 

  9. Woolfson D N, Peptide Sci 94 (2010) 118.

    Article  CAS  Google Scholar 

  10. Lee C H, Singla A and Lee Y, Int J Pharm 221 (2001) 1.

    Article  CAS  Google Scholar 

  11. Krishnamoorthy G, Stephen P, Prabhu M, Sehgal P K and Sadulla S, AIP conf Proc 1276 (2010) 163.

    Article  CAS  Google Scholar 

  12. Sehgal P K, Ahmed M R, Jayakumar R and Sripriya R, Indian Patent No. DEL (2001) 201.

  13. Velev O D, Adv Biophys 34 (1997) 139.

    Article  CAS  Google Scholar 

  14. Shahum E and Therien H M, Cell Immunol 123 (1989) 36.

    Article  CAS  Google Scholar 

  15. Elferink M G, de Wit J G, In’t Veld G, Reichert A, Driessen A J, Ringsdorf H and Konings W N, Biochim Biophys Acta 1106 (1992) 23.

    Article  CAS  Google Scholar 

  16. Sunamoto J and Iwamoto K, Crit Rev Ther. Drug Carrier Syst 2 (1986) 117.

    CAS  Google Scholar 

  17. Venkatesan N and Vyas S P, Int J Pharm 203 (2003) 169.

    Article  Google Scholar 

  18. Filipovic-Grcic J, Skalko-Basnet N and Jalsenjak I, J Microencapsul 18 (2001) 3.

    Article  CAS  Google Scholar 

  19. Martinez del Pozo A, Onaderra M, Laynez J and Gavilanes J G, Matrix 9 (1989) 405.

    CAS  Google Scholar 

  20. Ghannam M M, Mady M M and Khalil W A, Biophys Chem 80 (1999) 31.

    Article  CAS  Google Scholar 

  21. Shi X, Ma W, Sun C and Wu S, Biomaterials 22 (2001) 1627.

    Article  CAS  Google Scholar 

  22. Pokorny J, Davidek J, Chocholata V, Panek J, Bulantova H, Janitz W, Valentova H and Vierecklova M, Nahrung 34 (1990) 159.

    Article  CAS  Google Scholar 

  23. Pederson A W, Ruberti J W and Messersmith P B, Biomaterials 24 (2003) 4881.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Bioproducts Laboratory, Central Leather Research Institute (Council of Scientific & Industrial Research), Adyar, Chennai, 600 020, Tamil Nadu, India

    Ganesan Krishnamoorthy, Natarajan Krithica & Praveen Kumar Sehgal

  2. Chemical Laboratory, Central Leather Research Institute (Council of Scientific & Industrial Research), Adyar, Chennai, 600 020, Tamil Nadu, India

    Asit Baran Mandal

  3. Indian Shoe Federation, Egmore, Chennai, 600 008, Tamil Nadu, India

    Sayeed Sadulla

Authors
  1. Ganesan Krishnamoorthy
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  2. Natarajan Krithica
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  3. Praveen Kumar Sehgal
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  4. Asit Baran Mandal
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  5. Sayeed Sadulla
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Correspondence to Praveen Kumar Sehgal.

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Krishnamoorthy, G., Krithica, N., Sehgal, P.K. et al. Preparation and characterization of collagen coated cholesterol-free liposome nanoparticles matrix for drug carriers and tissue engineering application. Trans Indian Inst Met 64, 199 (2011). https://doi.org/10.1007/s12666-011-0039-z

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  • DOI: https://doi.org/10.1007/s12666-011-0039-z

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