Abstract
Alzheimer’s disease causes loss of memory and deterioration of mental abilities is utmost predominant neurodegenerative disease accounting 70–80% cases of dementia. The appearance of plaques of amyloid-β and neurofibrillary tangles in the brain post-mortems of Alzheimer’s patients established them as key participants in the etiology of Alzheimer’s disease. Exosomes exist as extracellular vesicles of nano-size which are present throughout the body. Exosomes are known to spread toxic hyperphosphorylated tau and amyloid-β between the cells and are linked to the loss of neurons by inducing apoptosis. Exosomes have progressed from cell trashcans to multifunctional organelles which are involved in various functions like internalisation and transmission of macromolecules such as lipids, proteins, and nucleic acids. This review covers current findings on relationship of exosomes in biogenesis and angiogenesis of Alzheimer’s disease and functions of exosomes in the etiology of AD. Furthermore, the roles of exosomes in development, diagnosis, treatment, and its importance as therapeutic targets and biomarkers for Alzheimer’s disease have also been highlighted.
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Chauhan, S., Behl, T., Sehgal, A. et al. Understanding the Intricate Role of Exosomes in Pathogenesis of Alzheimer’s Disease. Neurotox Res 40, 1758–1773 (2022). https://doi.org/10.1007/s12640-022-00621-4
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DOI: https://doi.org/10.1007/s12640-022-00621-4