Abstract
Cerebral ischemia/reperfusion (I/R) injury is the main cause of death following trauma. The neuroprotective effect of sevoflurane (Sev) has been implicated in cerebral I/R injury. However, the mechanisms remain elusive. In this study, we aimed to explore its function in PC12 exposed to oxygen–glucose deprivation/reoxygenation (OGD/R) and in rats challenged with I/R. Sev pretreatment reduced the damage of PC12 cells after OGD/R treatment. Moreover, Sev pretreatment ameliorated neurobehavioral deficits induced by I/R treatment, reduced brain infarct volume, and decreased apoptosis of neurons in hippocampal tissues. Sev pretreatment reduced the surface expression of glutamate receptor 1 (GRIA1) in neurons, while GRIA1 reduced the neuroprotective effects of Sev pretreatment in vitro and in vivo. There was no difference in the surface expression of GRIA2 in rats with I/R and PC12 cells exposed to OGD/R. The ratio of GRIA1/GRIA2 surface expression was reduced, and calcium permeable-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (CP-AMPAR) was blocked by Sev. Together, Sev might exert beneficial effects on cerebral I/R-induced neuronal injury through inhibiting the surface expression of GRIA1 and blocking CP-AMPAR.
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YL is the guarantor of integrity of the entire study and contributed to the concepts; ZL, SYL, XNW, and TY contributed to the experimental studies, data acquisition, and statistical analysis; KM and KC contributed to data analysis and manuscript review. All authors contributed to the manuscript preparation and read and approved the final manuscript.
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The procedures regarding animals were carried out as per the institutional guideline of Guide for the Care and Use of Laboratory Animals (proposed by NIH), and the protocols used in the present study were approved by the Ethics Committee for the Second Hospital of Hebei Medical University.
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Li, Y., Liang, Z., Lei, S. et al. Sevoflurane Preconditioning Downregulates GRIA1 Expression to Attenuate Cerebral Ischemia–Reperfusion-Induced Neuronal Injury. Neurotox Res 41, 29–40 (2023). https://doi.org/10.1007/s12640-022-00620-5
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DOI: https://doi.org/10.1007/s12640-022-00620-5