Abstract
Increasing evidences have demonstrated that inflammation is involved in the mechanisms of acute ischemic stroke (AIS). As an important and easy-to-measure inflammatory marker, neutrophil-to-lymphocyte ratio (NLR) shows a high association with mortality in patients with stroke in recent studies. In this study, we evaluated the prognostic role of NLR in patients with AIS. One hundred forty-three patients with AIS were enrolled. Clinical data were collected and the NLR was calculated from the admission blood work. The patients were followed up for 3 months after stroke onset. The occurrence of death and the major disability at 3 months after onset were end points in this study. Modified Rankin Scale score ≥3 was considered as poor outcome. In this study, 75 patients (52%) had poor outcome. We used binary logistic regression model to evaluate risk factor for poor outcome of AIS and found that the NLR was independently associated with the poor outcome of 3 months (P < 0.001). The optimal cutoff value for NLR as a predictor for 3-month outcome was 2.995. Therefore, in our study, high NLRs inversely predicted 3-month outcome in patients with AIS.
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This work was supported by the grants from National Natural Science Foundation of China (81361128010 and 81501081) and the Priority Academic Program Development of Jiangsu Higher Education Institutions of China.
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This study had been approved by the Ethics Committee of the Hefei Affiliated Hospital of Anhui Medical University and had therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
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Sen Qun and Yan Tang are co-first authors.
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Qun, S., Tang, Y., Sun, J. et al. Neutrophil-To-Lymphocyte Ratio Predicts 3-Month Outcome of Acute Ischemic Stroke. Neurotox Res 31, 444–452 (2017). https://doi.org/10.1007/s12640-017-9707-z
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DOI: https://doi.org/10.1007/s12640-017-9707-z