Abstract
Phytotherapy can be an alternative for the control of gastrointestinal parasites in human and animals. Coriander (Coriandrum sativum L.) is a medicinal plant which grown as a spice crop all over the world. The seeds of this plant have been used to treat parasitic disease, indigestion, diabetes, rheumatism and pain in the joints. This study was carried out to compare the efficacy of Niclosamid and alcoholic seed extract of C. sativum on Hymenolepis nana infection, in vivo and vitro. For in vivo study, Balb/c mice were used, to compare the efficacy of 50 mg/kg body weight (B.W) of Niclosamid with different doses of alcoholic extracts of C. sativum (250, 500, and 750 mg/kg B.W). It was found that the efficacy of Niclosamid had reached 100 % after 11 days post treatment, while the efficacy of 500 and 750 mg/kg B.W of C. sativum reached to 100 % after 15 days after treatment. For in vitro study, special nutrient broth media was used. It was found that the addition of 1000 mg/ml of Niclosamid had paralyzed and killed worms within 5 min, while C. sativum killed them within 30 min. Our results showed that extract of C. sativum has good effect against H. nana and could be use in traditional medicine for treatment of parasitic disease.
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Alvarez-Fernandez BE, Rodrfguez-Bataz E, Dfaz-Chiguer DL, Marquez-Navarro A, Sanchez-Manzano RM, Nogueda-Torres B (2012) Mixed Hymenolepis species infection in two family members: a case report from an urban area of Chilpancingo, Guerrero, México. Trop Gastroenterol 33:83–84
Asgarpanah J, Kazemivash N (2012) Phytochemistry, pharmacology and medicinal properties of Coriandrum sativum L. Afr J Pharm Pharmacol 6:2340–2345
Eguale T, Tilahun G, Debella A, Feleke A, Makonnen E (2007) In vitro and in vivo anthelmintic activity of crude extracts of Coriandrum sativum against Haemonchus contortus. J Ethnopharmacol 110:428–433
Hotez PJ, Ehrenberg JP (2010) Escalating the global fight against neglected tropical diseases through interventions in the Asia Pacific region. Adv Parasitol 72:31–53
Hotez PJ, Kamath A (2009) Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis 3:e412
Hrckova G, Velebny S (2013) Parasitic helminths of humans and animals: health impact and control. Pharmacological potential of selected natural compounds in the control of parasitic diseases. Springer, Vienna, pp 29–99
Kline K, McCarthy JS, Pearson M, Loukas A, Hotez PJ (2013) Neglected tropical diseases of Oceania: review of their prevalence, distribution, and opportunities for control. PLoS Negl Trop Dis 7:e1755
Leder K, Weller P, Weller PF, Baron EL (2013) Intestinal tapeworms. Up To Date, Waltham 2
Levecke B et al (2011) A comparison of the sensitivity and fecal egg counts of the McMaster egg counting and Kato-Katz thick smear methods for soil-transmitted helminths. PLoS Negl Trop Dis 5:e1201
Malheiros AF, Mathews PD, Lemos LMS, Braga GB, Shaw JJ (2014) Prevalence of Hymenolepis nana in indigenous Tapirapé Ethnic group from the Brazilian Amazon. Am J Biomed Res 2:16–18
Maroufi K, Farahani HA, Darvishi HH (2010) Importance of coriander (Coriandrum Sativum L.) between the medicinal and aromatic plants. Adv Environ Biol 4:433–436
Matasyoh J, Maiyo Z, Ngure R, Chepkorir R (2009) Chemical composition and antimicrobial activity of the essential oil of Coriandrum sativum. Food Chem 113:526–529
Pal BC, Ross RH, Milman HA (1984) Nutritional requirements and contaminant analysis of laboratory animal feeds. Oak Ridge National Lab, Tennessee
Parvathi J, Karemungikar A (2011) Leucocyte variation, an insight of host defenses during hymenolepiasis and restoration with praziquantel. Indian J Pharm Sci 73:76–79
Patel J, Kumar G, Qureshi MS, Jena P (2011) Anthelmintic activity of ethanolic extract of whole plant of Eupatorium Odoratum. L. Int J Phytomed 2:127–132
Sadaf H, Khan S, Kanwal N, Tasawer B, Ajmal S (2013) A review on diarrhoea causing Hymenolepis nana-dwarf tapeworm. Int Res J Pharm 4:32–35
Sahib NG, Anwar F, Gilani AH, Hamid AA, Saari N, Alkharfy KM (2013) Coriander (Coriandrum sativum L.): a potential source of high-value components for functional foods and nutraceuticals—a review. Phytother Res 27:1439–1456
Taniguchi M, Yanai M, Xiao YQ, T-i Kido, Baba K (1996) Three isocoumarins from Coriandrum sativum. Phytochemistry 42:843–846
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We would like to thank all the people who cooperated in this study especial researcher and worker in Institute Pasteur, Tehran, Iran.
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The authors have no financial or personal relationship with other people or organizations that could inappropriately influence or bias this paper.
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Hosseinzadeh, S., Ghalesefidi, M.J., Azami, M. et al. In vitro and in vivo anthelmintic activity of seed extract of Coriandrum sativum compared to Niclosamid against Hymenolepis nana infection. J Parasit Dis 40, 1307–1310 (2016). https://doi.org/10.1007/s12639-015-0676-y
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DOI: https://doi.org/10.1007/s12639-015-0676-y