Abstract
Purpose
When children with autism spectrum disorder (ASD) are in hospital, difficulties with socialization, communication, and behaviour can be exacerbated. The purpose of this study was to establish feasibility of an enhanced perioperative care pathway.
Methods
Utilizing parental and provider feedback, a protocol including environment modification, anxiolysis plans, specialized order sets, and child life specialist (CLS) support was developed over a nine-month period. Autism severity scores (ASS), communication styles, triggers, and previous experiences were used to create individualized care plans in the preoperative clinic. Emotion and sedation scores in the same day surgery unit, at anesthesia induction, and in the postanesthesia care unit were recorded. Acceptance was obtained from nurses, anesthesiologists, and parents. Feasibility criteria included the recruitment rate, adherence to protocol, data collection, and patient follow-up.
Results
Eighteen patients were enrolled in this pilot study. All feasibility criteria including recruitment, adherence to study protocol (97%), and follow-up (94%) were met. Fifteen (83%) patients were nonverbal and minimally interactive (ASS = 3). Common triggers were loud noises (78%), crowds (78%), and bright lights (56%). After implementation of the protocol, 15 (83%) of the anesthetic inductions were described as excellent. Ten different premedication plans were used. Parents described the personalized plan, anxiolysis medication, and CLS support as advantageous. All (100%) nurses, anesthesiologists, and parents felt the program should continue.
Conclusion
We showed that a multidisciplinary perioperative care plan for children with severe ASD was feasible and 100% accepted at our institution. The individual nature of anxiolysis plans was considered a strength of the protocol.
Résumé
Objectif
Lorsque des enfants souffrant d’un trouble du spectre de l’autisme (TSA) sont à l’hôpital, leurs difficultés en matière de socialisation, de communication et de comportement peuvent être exacerbées. L’objectif de cette étude était d’établir la faisabilité d’un plan d’intervention périopératoire optimisé.
Méthode
En nous fondant sur les commentaires des parents et des professionnels des soins de santé, un protocole comprenant des modifications de l’environnement, des plans de gestion de l’anxiété, des ensembles d’ordonnances spécialisés et le soutien d’un spécialiste de l’enfance a été mis au point sur une période de neuf mois. Les scores de sévérité de l’autisme (SSA), les styles de communication, les déclencheurs et les expériences passées ont été utilisés afin de créer des plans d’intervention personnalisés en clinique préopératoire. Les scores d’émotion et de sédation ont été enregistrés à l’unité de chirurgie d’un jour, à l’induction de l’anesthésie et en salle de réveil. L’accord sur le plan d’intervention a été obtenu du personnel infirmier, des anesthésiologistes et des parents. Les critères de faisabilité comprenaient le taux de recrutement, l’observance du protocole, la collecte de données et le suivi des patients.
Résultats
Dix-huit patients ont été recrutés dans cette étude pilote. Tous les critères de faisabilité, y compris le recrutement, l’observance du protocole (97 %) et le suivi (94 %), ont été respectés. Quinze (83%) patients étaient non verbaux et minimalement interactifs (SSA = 3). Les déclencheurs fréquents étaient les bruits forts (78 %), les foules (78 %), et les lumières vives (56 %). Après la mise en œuvre du protocole, 15 (83 %) des inductions anesthésiques ont été décrites comme excellentes. Dix plans de prémédication différents ont été utilisés. Les parents ont estimé que le plan d’intervention personnalisé, la médication anxiolytique et le soutien du spécialiste de l’enfance étaient bénéfiques. Tous les intervenants (100 %, c’est-à-dire personnel infirmier, anesthésiologistes et parents) étaient d’avis que le programme devrait se poursuivre.
Conclusion
Nous avons démontré qu’un plan d’intervention périopératoire multidisciplinaire spécialement conçu pour les enfants souffrant de TSA sévère était faisable et accepté à 100 % dans notre institution. La nature personnalisée des plans de gestion de l’anxiété a été considérée comme l’une des forces du protocole.
Similar content being viewed by others
Autism spectrum disorder (ASD) is diagnosed in 1 in 68 children in North America.1 Children with autism may have difficulties with sensory processing and language communication skills, and may require strict adherence to routines or stereotypic behaviours. Abnormal sensory processing is present in 40–80% of children with ASD.2 Prolonged preoperative fasting times and the wide array of sensory insults present in the operating room (OR) environment (e.g., fluorescent lights, crying children, pungent volatile anesthetics) can be problematic in this population and lead to traumatic inductions, postoperative agitation, aggression, and flight behaviour. Children with ASD often have better visual versus verbal communication skills and may have difficulty interpreting social cues.3 In a parental survey in 2013, Kopecky found only 23% of children expressed their needs verbally.4 Concomitant medical issues, psychologic concerns (hyperactivity, obsessive-compulsive behaviours, tics), and intellectual disability may further complicate behavioural challenges.4 Because of fundamental differences in communication style, healthcare providers often feel ill-equipped to communicate with a child with ASD and feel they would benefit from further training.5,6 This combination of factors results in high perioperative stress for children, parents, and healthcare providers. Lindberg et al. surveyed 12 parents of children with ASD, many of whom described their perioperative experience as “disgraceful”, “unspeakable suffering”, and a “hopeless struggle”.7
Despite its prevalence, children with ASD are historically an underserviced group of individuals. Rainey and van der Walt proposed an integrated preoperative management program for children with ASD that focused on early identification and collection of detailed information regarding specific triggers.8 Anesthesia-related protocols previously focused on sedating combative behaviour, but behaviourally informed interventions are improving clinical outcomes.9 Individualized plans that minimize known stressors have been shown to decrease non-compliance at induction from 50% to 17%, without the use of premedication.10 A systematic review by Koski et al. stressed the importance of individualized care when designing a protocol to minimize stress in children with ASD. Three main themes emerged relating to the development of a perioperative care pathway: 1) collaborating with the caregiver to inform management; 2) developing a process for communicating information from caregiver to staff; and 3) modifying the perioperative environment based on patient-specific needs.11
With these considerations in mind, we developed a multidisciplinary care plan for children with severe ASD including both environmental modification and individualized anxiolysis to improve the perioperative experience (Figure). Herein, we describe its development and assess the feasibility of continuing the program.
Methods
Study design
We conducted a pilot trial of pediatric patients with severe ASD scheduled for surgery at a single-centre Canadian tertiary care pediatric hospital over a nine-month period from March 1 2016 to November 25 2016. Over the course of the study period, changes to the protocol were made based on parental feedback. This pilot study was conducted after local Research Ethics Board approval (Hamilton Integrated Research Ethics Board #15-168) and was reported in line with the CONSORT (Consolidated Standards of Reporting Trials) guidelines.12
Participants
Patients were enrolled from the preoperative clinic at the discretion of the pediatric anesthesiologist. All pediatric patients are seen preoperatively at our institution. Any child aged three to 17 yr with symptoms of severe ASD was eligible; nevertheless, patients that were nonverbal, had a history of traumatic inductions, or exhibited inability to cope during the preoperative appointment were prioritized. Only patients with procedures (dental, urology, otolaryngology, orthopedic) booked in the main OR were included, as procedures in outpatient areas are covered by a separate sedation service. Children < three years of age were not included because there is usually no formal diagnosis of ASD at this age.13 Consent was obtained from caregivers at the time of enrollment by a research assistant after being approached by the child life specialist (CLS).
Study protocol
A psychosocial assessment including both observation and parental feedback was completed preoperatively by the CLS (eAppendix 1, available as Electronic Supplementary Material [ESM]). Patients were assessed using a four-level ASS developed by Hudson to communicate level of severity (eAppendix 1, available as ESM).14 Nevertheless, severity scores were re-coded and reported using the more recent three-level scale described in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition.15 Along with information regarding specific triggers and the anticipated level of sedation required, the pediatric anesthesiologist in the preoperative clinic would develop a “Special Accommodations protocol” with the family including pre-procedure individualized anxiolysis medication and environment modification. A specialized order set (eAppendix 2, available as ESM) outlined options for medication including midazolam (0.25 mg·kg−1 or 0.5 mg·kg−1) and/or ketamine (3 mg·kg−1 or 6 mg·kg−1) with the medications to be given orally or intramuscularly (individually or in combination). Routine anti-sialagogues were not used. Medication doses were based on previous studies that examined optimal doses for anesthetic premedication in children with ASD.16,17,18,19 Patients were to be booked as the first case of the day and identified on the main OR list as “special accommodations”. The npo times were not altered from institutional policy. Wait times in the preoperative clinic were minimized for patients with ASD. Surgeons were asked to identify patients with severe ASD when booking clinic appointments.
On the day of surgery, patients had an expedited preoperative course. Normally, patients are admitted 1.5 hr prior to surgery and have multiple transitions—i.e., admission office, same day surgery (SDS) intake, and group preoperative holding area (with multiple children and families). Children with special accommodations were admitted 1 hr prior to their procedure directly to a private quiet room away from non-sedated children. They were attended by a CLS and SDS nurse. Patients were not required to change clothes or have routine vitals done. Anxiolysis medication was administered in the clear fluid of choice of the child by a parent or the SDS nurse. Intravenous (IV) access was obtained as sedation levels allowed or based on the child’s individualized plan. An IV was avoided if there was a history of traumatic IV starts.
The number of personnel in the OR was kept to a minimum (signs were placed on the OR doors indicating nonessential personnel should keep out) and room lights were dimmed during the anesthetic induction. The CLS and parents accompanied the patient to the OR; parental presence is routine at our institution. Intraoperative management was at the discretion of one of the four pediatric anesthesiologists involved in the study. Parents were debriefed post-induction by the CLS.
Postoperatively, patients were admitted to a quiet recovery bay with dimmed lights. A specialized order set (eAppendix 3, available as ESM) was used by the postanesthesia care unit (PACU) nurses to guide monitoring, early IV removal, and direct discharge to home from the PACU as soon as the patient met usual discharge criteria (a score of 18–20 based on a modified postanesthesia discharge scoring scale).20 Familiar toys, parental presence, and individual coping strategies (e.g., music, weighted blankets, and service animals) were utilized on emergence as per the child’s plan.
Feasibility was the primary outcome; in addition, whether the interventions were perceived as disruptive or helpful were also recorded. The patient’s activity level/emotional state were documented at arrival to the SDS, at induction, and in the PACU according to scales derived by Gutstein et al.21 These scores have been used and validated in studies investigating pediatric premedication using midazolam and ketamine in non-ASD children.22,23,24,25 They have not been validated for children with ASD. Of note, there is no premedication or perioperative anxiety score validated for the ASD population. Compliance with anxiolysis medication, time between sedation and admission to the OR, quality of anesthetic induction, presence of emergence agitation, nausea/vomiting, and time to discharge were also recorded.
Formal feedback and post-intervention comments were collected from parents, SDS nursing staff, and anesthesia and PACU nursing staff. Parents were asked to compare this experience with previous OR experiences using a paper questionnaire filled out while the child was in the OR. Parents were asked specifically what interventions were helpful during their stay, what could have been improved, whether the child had difficulties during their stay, and what was done.
Outcomes
The primary outcome was the feasibility of a perioperative protocol for children with ASD. Feasibility was defined as the ability to enroll ten patients with ASD over a six-month period, greater than 90% adherence to the study protocol, and 90% follow-up with caregiver/parent feedback. Secondary outcomes included emotion and sedation scores pre- and post-anxiolysis medication and the quality of anesthetic induction. Parental satisfaction was used both to gauge the efficacy of the intervention and to make modifications to the protocol. The written comments from the parents’ completed feedback forms (eAppendix 4, available as ESM) were analyzed using established qualitative thematic analysis; two authors (L.B., A.W.) individually reviewed and inductively coded all of the written comments to identify meaningful feedback.26,27 Related codes were amalgamated under common categories and organized in table form to identify recurring thematic patterns. They compared their analyses to ensure the thematic categories comprehensively captured all of the data and resolved discrepancies through discussion.
Statistical analysis
The descriptive summary of patient demographics, prognostics, and surgical information was reported as count (%) for categorical variables and mean (standard deviation [SD]) for continuous variables. The sample size was based on the prediction of two to four severely autistic patients presenting to the OR per month. A sample size of ten patients allowed data to be collected over a period of approximately six months while still being representative of the larger population study.28
Results
Over a nine-month period, 18 patients completed the Special Accommodations program, which included modifications from the preoperative clinic to discharge home from PACU on the day of surgery. There were no cancellations, despite 15 (83%) ASS level 3 patients (i.e., nonverbal and minimally interactive) taking part. Many of these children had a history of traumatic experiences in the hospital, and 11 (72%) had a history of combative or aggressive behaviour. Age ranged from three to 16 yr with a mean (SD) age of 8 (3.5) years. The most common reported triggers were loud noises and crowds (78%), and bright lights (56%). Over half (67%) of patients underwent dental procedures. The mean (SD) sedation time preoperatively was 38.6 (15.7) min, mean (SD) procedure duration was 81 (43) min and mean (SD) PACU stay to discharge home was 93 (37) min (Table 1). One patient had an unanticipated postoperative admission for more extensive orthopedic surgery.
All feasibility criteria were met including recruitment of two patients/month, 97% adherence to the study protocol, 95% data acquisition, and 94% patient follow-up (Table 2).
Ten different anxiolysis medication combinations were used (Table 3). A combination of midazolam and ketamine was utilized in 11 (60%) of the cases. Fifteen (94%) of the inductions were described as very good or excellent by the anesthesiologist managing the case whether via inhalational (61%) or IV (39%) induction (Table 4). Sedation increased from a mean (SD) score of 4.2 (0.9) pre-sedation to 2.7 (0.9) at induction, following administration of premedication. Emotion scores decreased from a mean (SD) of 1.9 (0.9) to 1.3 (0.5) at induction.
Parental feedback identified several positive elements of the program (Table 5). Ten parents (55%) commented on the benefit of the personalized approach/sedation plans and eight parents (44%) commented on the presence of CLS workers. The use of preoperative anxiolysis medication (33%), parental presence at induction and emergence (33%), decreased wait times (28%), the patience displayed by healthcare providers (27%), and the use of a quiet room (28%) were also noted as strengths of the program by parents.
Feedback from healthcare providers was also very positive (Table 6). With 100% acceptability, healthcare providers (SDS, OR, PACU, and anesthesiologists) felt that the program should continue. Perceived strengths of the program included its multidisciplinary structure, the use of preoperative anxiolysis medications, and its family-centred approach. One of the issues raised was the increased nurse:patient ratio that was required in PACU for the Special Accommodations program patients. Early feedback also included comments about the need for early identification of patients requiring special accommodations.
Discussion
This pilot trial shows that an individualized perioperative care plan using a multidisciplinary team is feasible at our institution to improve the perioperative experience for children with ASD. The concept of individualized sedation planning is not novel; nevertheless, only recently have a small number of Canadian institutions (predominantly at tertiary pediatric hospitals) adapted this approach into a formalized process. In 2017, Swartz et al. reported perioperative care plans for children with ASD, resulting in 90% overall cooperation at induction of anesthesia with preoperative sedation administered to only 38% of the entire cohort (50% in the severe group).29 One benefit of our protocol identified by parents was the presence of the CLS. The addition of a CLS helped to focus coping strategies for the child and parent and ensure individualized plans were carried out. Some of these plans included service animals in the SDS holding area, mobilizing with supervision while waiting for the OR, removing siblings and/or other additional personnel from the patient’s room, acting as a liaison between healthcare providers and family, and providing distraction.
Our pilot trial targeted children with severe ASD and consequently many plans utilized anxiolytic premedication. The type of premedication varied widely from child to child and was determined by considerations such as taste sensitivity, compliance with oral medication, previous experience with pre-induction sedation, expected level of cooperation, and body mass index. Currently, there is insufficient evidence in the literature to support one medication over another, although some reviews have suggested using alpha-agonists with midazolam over ketamine because of the side effect profile.3 At the time of this pilot study, dexmedetomidine was not available in our hospital.
Monitoring in the SDS was a concern at the onset of the pilot trial—no patients experienced desaturation or required supplemental oxygen. In fact, 20% required an additional dose of medication to achieve a suitable level of sedation. Arnold described intramuscular (IM) ketamine use in 85% of patients with ASD (not stratified by severity)30; 11% of individual plans utilized IM ketamine (one elective, one rescue) in our study. Although effective, routine use of IM medications can lead to increased anxiety with repeated visits and may not be a sustainable option.18 Ketamine has been associated with emergence agitation and unwanted side effects, particularly increased secretions and nausea. Despite other studies citing no adverse effects of ketamine,29 the two episodes of nausea observed in this pilot study were both after IM ketamine had been administered. Given the potentially unfavourable side effect profile of ketamine and longer recovery time at higher doses,31 other medications, including dexmedetomidine, will be considered in future studies.32,33
In this pilot, anesthetic management was at the discretion of the anesthesia provider; nevertheless, variability in technique was minimized by limiting the number of providers. Patients were given 1–2 µg·kg−1 fentanyl at the beginning of the case and maintained on sevoflurane for the procedure. As is standard practice at our institution, ondansetron (0.1 mg·kg−1), dexamethasone (0.1 mg·kg−1), and Tylenol 40 mg·kg−1 pr were administered intraoperatively. Three patients required morphine (0.02–0.05 mg·kg−1) for procedures with expected postoperative pain—tonsillectomy (n = 2) and osteotomy (n = 1). As more concerns are raised about the potentially decreased oxidative capacity and impaired methylation in children with ASD,34,35 the use of short-acting medications and avoidance of certain drugs including nitrous oxide, prolonged infusions of propofol, or adding B12 supplementation may be considered. Balancing the need for pre-induction sedation and attempting to minimize drug exposure in patients with ASD is complex; traumatic inductions have been associated with postoperative general anxiety, enuresis, night-time crying, and temper tantrums. These changes are usually transient but may persist for up to one year in some individuals.36
The overwhelming feedback we received from healthcare workers was that this program should continue. These results support the work of Thompson and Tielsch-Goddard who found increased staff interest in optimizing the surgical experience for children with ASD and increased satisfaction when additional attention is given to minimizing stress for families in the perioperative period.6 Consistency in staff members caring for a patient with ASD can be very beneficial.9 In our system, the patient is seen by different staff at the preoperative visit, before the OR and postoperatively; this is a potential area for improvement in the future. The increased nurse:patient ratio both in SDS and PACU was identified by healthcare providers as a potential difficulty. Nurses will typically be assigned to at least two patients in SDS and in PACU (once patients are awake and responding to commands). Mean recovery time in the PACU was 95 min, at which point patients were discharged directly home. This was shorter than the combined PACU/SDS stay of approximately 150 min that most patients experience (most patients stay 40–60 min in PACU and 90 min in SDS before discharge home at our institution). As in other aspects of the protocol there appeared to be a learning curve with the last four patients being discharged from PACU in 60 min with an overall trend of decreasing recovery time. Although we cannot decrease the nursing ratio, we have been able to minimize the time it is required. Additionally, a very agitated patient with ASD will definitely require an increased nursing ratio. One patient did have an extended PACU stay because of an unanticipated admission (surgical cause) and unavailability of an inpatient bed, which resulted in the only incidence of combative behaviour. This highlighted the need for our protocol to include expedited inpatient transfers.
Parental feedback weighed heavily into our protocol design. Several suggestions were made during the pilot for further environment modification including visual communication boards, additional parent information specific for children with ASD, and the need for consistency across visits, which were implemented. Unfortunately, we were unable to complete reliable post-discharge home follow-up. Parental feedback was obtained post-induction while their child was in the OR. Although this was a reliable way to obtain feedback, information on postoperative behaviour changes, sleep disturbance, and postoperative nausea and vomiting after discharge was not collected. This is an important area for improvement in future studies.
The success of the protocol was assessed using feedback from parents and healthcare providers, and using sedation and emotional scales. The sedation and emotional scales were previously developed to assess effectiveness of preanesthetic medication.22,23,25 Future studies should more precisely capture the anxiety level of patients distinct from their level of sedation; this may require using a different scale. Patients with ASD are believed to have a higher incidence of anxiety; nevertheless, no anxiety scale is currently validated for autistic children.37 As the larger study will include both severe and higher functioning patients with ASD, having feedback from the patients directly will be an important additional source of information.
This pilot study shows that a multidisciplinary perioperative care pathway that improves the perioperative experience for severely autistic children and their families is feasible at our institution, which previously did not utilize premedication, quiet rooms, or CLS. With 100% acceptability among healthcare providers, our Special Accommodations program, which features individualized planning, formalized communication between healthcare providers and parents, and discriminant use of premedication, has changed practice at our institution.
References
Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators; Centers for Disease Control and Prevention (CDC). Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ 2014; 63: 1-21.
Helfin L, Alaimo D. Students with Autism Disorders: Effective Instructional Practices. Upper Saddle River, NJ: Pearson/Merrell Prentice Hall; 2007 .
Taghizadeh N, Davidson A, Williams K, Story D. Autism spectrum disorder (ASD) and its perioperative management. Paediatr Anaesth 2015; 25: 1076-84.
Kopecky K, Broder-Fingert S, Iannuzzi D, Connors S. The needs of hospitalized patients with autism spectrum disorders: a parent survey. Clin Pediatr (Phila) 2013; 52: 652-60.
Davignon MN, Friedlaender E, Cronholm PF, Paciotti B, Levy SE. Parent and provider perspectives on procedural care for children with autism spectrum disorders. J Dev Behav Pediatr 2014; 35: 207-15.
Thompson DG, Tielsch-Goddard A. Improving management of patients with autism spectrum disorder having scheduled surgery: optimizing practice. J Pediatr Health Care 2014; 28: 394-403.
Lindberg S, von Post I, Eriksson K. The experiences of parents of children with severe autism in connection with their children’s anaesthetics, in the presence and absence of the perioperative dialogue: a hermeneutic study. Scand J Caring Sci 2012; 26: 627-34.
Rainey L, van der Walt JH. The anaesthetic management of autistic children. Anaesth Intensive Care 1998; 26: 682-6.
Nelson D, Amplo K. Care of the autistic patient in the perioperative area. AORN J 2009; 89: 395-7.
van der Walt JH, Moran C. An audit of perioperative management of autistic children. Paediatr Anaesth 2001; 11: 401-8.
Koski S, Gabriels RL, Beresford C. Interventions for paediatric surgery patients with comorbid autism spectrum disorder: a systematic literature review. Arch Dis Child 2016; 101: 1090-4.
Eldridge SM, Chan CL, Campbell MJ, et al. CONSORT 2010 statement: extension to randomised pilot and feasibility trials. BMJ 2016; 355: i5239.
Mandell DS, Novak MM, Zubritsky CD. Factors associated with age of diagnosis among children with autism spectrum disorders. Pediatrics 2005; 116: 1480-6.
Hudson J. Prescription for Success: Supporting Children with Autism Spectrum Disorders in the Medical Environment. Shawnee Mission, KS: Autism Asperger Publishing Company; 2006 .
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington VA: American Psychiatric Association; 2013. p. 50.
Short JA, Calder A. Anaesthesia for children with special needs, including autism spectrum disorder. Continuing Education in Anaesthesia Critical Care & Pain 2013; 13: 107-12.
Shah S, Shah S, Apuya J, Gopalakrishnan S, Martin T. Combination of oral ketamine and midazolam as a premedication for a severely autistic and combative patient. J Anesth 2009; 23: 126-8.
Christiansen E, Chambers N. Induction of anesthesia in a combative child; management and issues. Paediatr Anaesth 2005; 15: 421-5.
Darlong V, Shende D, Subramanyam MS, Sunder R, Naik A. Oral ketamine or midazolam or low dose combination for premedication in children. Anaesth Intensive Care 2004; 32: 246-9.
Aldrete JA. The post-anesthesia recovery score revisited. J Clin Anesth 1995; 7: 89-91.
Gutstein HB, Johnson KL, Heard MB, Gregory GA. Oral ketamine preanesthetic medication in children. Anesthesiology 1992; 76: 28-33.
Funk W, Jakob W, Riedl T, Taeger K. Oral preanaesthetic medication for children: double-blind randomized study of a combination of midazolam and ketamine vs midazolam or ketamine alone. Br J Anaesth 2000; 84: 335-40.
Beebe DS, Belani KG, Chang PN, et al. Effectiveness of preoperative sedation with rectal midazolam, ketamine, or their combination in young children. Anesth Analg 1992; 75: 880-4.
Mitchell V, Grange C, Black A, Train J. A comparison of midazolam with trimeprazine as an oral premedicant for children. Anaesthesia 1997; 52: 416-21.
Alderson PJ, Lerman J. Oral premedication for paediatric ambulatory anaesthesia: a comparison of midazolam and ketamine. Can J Anaesth 1994; 41: 221-6.
Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol 2006; 3: 77-101.
Ergun S, Busse JW, Wong A. Mentorship in anesthesia: a survey of perspectives among Canadian anesthesia residents. Can J Anesth 2017; 64: 402-10.
Thabane L, Ma J, Chu R, et al. A tutorial on pilot studies: the what, why and how. BMC Med Res Methodol 2010; 10: 1.
Swartz JS, Amos KE, Brindas M, Girling LG, Graham MR. Benefits of an individualized perioperative plan for children with autism spectrum disorder. Paediatr Anaesth 2017; 27: 856-62.
Arnold B, Elliott A, Laohamroonvorapongse D, Hanna J, Norvell D, Koh J. Autistic children and anesthesia: is their perioperative experience different? Paediatr Anaesth 2015; 25: 1103-10.
Petros AJ. Oral ketamine. Its use for mentally retarded adults requiring day care dental treatment. Anaesthesia 1991; 46: 646-7.
Ray T, Tobias JD. Dexmedetomidine for sedation during electroencephalographic analysis in children with autism, pervasive developmental disorders, and seizure disorders. J Clin Anesth 2008; 20: 364-8.
Lubisch N, Roskos R, Berkenbosch JW. Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. Pediatr Neurol 2009; 41: 88-94.
Herbert M. Autism: a brain disorder or a disorder that affects the brain? Clinical Neuropsychiatry 2005; 2: 354-79.
James SJ, Cutler P, Melnyk S, et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004; 80: 1611-7.
Watson AT, Visram A. Children’s preoperative anxiety and postoperative behaviour. Paediatr Anaesth 2003; 13: 188-204.
White SW, Oswald D, Ollendick T, Scahill L. Anxiety in children and adolescents with autism spectrum disorders. Clin Psychol Rev 2009; 29: 216-29.
Acknowledgements
The authors gratefully acknowledge the participation and support of the perioperative staff at McMaster Children’s Hospital, without whom this project would not have been possible. We thank Sara Miller M.Sc., Scientific Editor, Department of Anesthesia – Research Office, McMaster University for editing this manuscript.
Conflicts of interest
None declared.
Editorial responsibility
This submission was handled by Dr. Hilary P. Grocott, Editor-in-Chief, Canadian Journal of Anesthesia.
Author contributions
Amanda Whippey contributed to all aspects of this manuscript, including study conception and design; acquisition, analysis, and interpretation of data; and drafting the article. Leora Bernstein contributed to the study conception and design, analysis of the data, and drafting of the manuscript. Debra O’Rourke contributed to the study conception and design, and acquisition of data. Desigen Reddy contributed to all aspects of this manuscript, including study conception and design; acquisition, analysis, and interpretation of data; and drafting the article.
Funding
None declared.
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Whippey, A., Bernstein, L.M., O’Rourke, D. et al. Enhanced perioperative management of children with autism: a pilot study. Can J Anesth/J Can Anesth 66, 1184–1193 (2019). https://doi.org/10.1007/s12630-019-01410-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12630-019-01410-y