Abstract
Objectives
Frailty is one of the major health problems facing aging societies worldwide. We investigated the association between serum SIRT6 and frailty in older adults.
Design
Cross-sectional analysis of associations of serum SIRT6 and frailty in older people.
Setting
Enrolled community-dwelling and hospital outpatient clinic adults older than 65 years old in Wuhan City, Hubei Province, China.
Participants
A total of 540 community-dwelling older adults (age ≥ 65 years) in Wuhan were included in the study.
Measures
We used Frailty Phenotype criteria for classifying participants based on their frailty status. Serum SIRT6 was measured using an ELISA kit.
Results
A total of 540 older adults were included in this cross-sectional study. Serum SIRT6 was lower in the slowness group (7.23±1.81 vs 5.89±1.74, p<0.001), weakness group (6.87±1.88 vs 5.68±1.64, p<0.001), and exhaustion group (6.73±1.90 vs 5.88±1.74, p<0.001) compare with the normal group. ROC curves were used to assess the efficiency of SIRT6 in predicting frailty in older adults. The AUC for SIRT6 was 0.792 (95% CI: 0.7514 to 0.8325), with the highest sensitivity of 68.0% and the specificity of 91.9%, and the optimal critical value of 4.65ng/ml according to Youden’s index. Multivariate logistic regression analysis showed that serum SIRT6 level was independently associated with frailty in older people.
Conclusion
In conclusion, serum SIRT6 was decreased in frailty compared with robust older adults. A decreased serum SIRT6 was independently associated with an increased risk of frailty. SIRT6 may be a potential target for the treatment of patients with frailty.
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Availability of data and materials: Data for this study are available from the corresponding author.
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Acknowledgments: Study concept and design: ZX, MZ; Data curation and analysis: MZ, XY Writing - original draft: MZ; Writing - review, and editing: ZX, MZ, XY, YH, ZW. All authors read and approved the final manuscript.
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Funding: This study was supported by the National Key Research and Development Program of China (2018YFC2002000).
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Ethical statement: The research protocol was approved by the Medical Ethics Committee of Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology (IRB ID: [2022] IEC (RYJ010)). All the participants gave written informed consent.
Declaration of Conflicting Interests: The authors report no conflicts of interest.
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Zhu, M., Yang, X., Huang, Y. et al. Serum SIRT6 Levels Are Associated with Frailty in Older Adults. J Nutr Health Aging 27, 719–725 (2023). https://doi.org/10.1007/s12603-023-1969-y
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DOI: https://doi.org/10.1007/s12603-023-1969-y